Development Level

Tbio 36 | 11,445
Tchem 6 | 1,598
Tclin 1 | 613
Tdark 1 | 6,588

IMPC Phenotype

increased bone mineral density 2 | 72
abnormal bone structure 1 | 187
abnormal coat- hair morphology 1 | 19
abnormal embryo size 1 | 220
abnormal eye size 1 | 7
abnormal hair growth 1 | 10
abnormal kidney morphology 1 | 65
abnormal nail morphology 1 | 8
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal tooth morphology 1 | 24
abnormal vibrissa morphology 1 | 25
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating glucose ... 1 | 126
decreased circulating glycerol... 1 | 16
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased heart weight 1 | 27
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
hyperactivity 1 | 148
hypoactivity 1 | 132
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 36
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499
small adrenal glands 1 | 16

Disease

Carcinoma 26 | 11,493
ovarian cancer 25 | 8,520
psoriasis 23 | 6,694
osteosarcoma 22 | 7,950
ependymoma 15 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
malignant mesothelioma 14 | 3,232
medulloblastoma, large-cell 14 | 6,241
Astrocytoma, Pilocytic 13 | 3,081
Atherosclerosis 13 | 291
atypical teratoid / rhabdoid tumor 13 | 5,112
glioblastoma 13 | 5,792
invasive ductal carcinoma 13 | 2,951
lung cancer 13 | 4,740
group 3 medulloblastoma 12 | 4,104
adult high grade glioma 11 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
Down syndrome 10 | 499
diabetes mellitus 10 | 1,728
subependymal giant cell astrocytoma 10 | 2,287
Lipid metabolism disorder 9 | 114
adrenocortical carcinoma 9 | 1,428
interstitial cystitis 9 | 2,312
lung carcinoma 9 | 2,843
pancreatic cancer 9 | 2,398
Coronary artery disease 8 | 268
Obesity 8 | 678
ductal carcinoma in situ 8 | 1,745
Autosomal recessive predisposition 7 | 1,442
Cancer 7 | 2,499
Intellectual disability 7 | 1,016
Schizophrenia 7 | 1,160
astrocytic glioma 7 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
oligodendroglioma 7 | 2,850
tuberculosis 7 | 2,010
Hepatomegaly 6 | 285
Hypercholesterolemia, Familial 6 | 23
Hyperlipoproteinemia Type II 6 | 12
Kidney cancer 6 | 2,613
active Crohn's disease 6 | 922
active ulcerative colitis 6 | 764
cystic fibrosis 6 | 1,696
juvenile dermatomyositis 6 | 1,187
lung adenocarcinoma 6 | 2,716
primitive neuroectodermal tumor 6 | 3,035
spina bifida 6 | 1,074
Alzheimer's disease 5 | 658
Cardiovascular system disease 5 | 246
Cerebrovascular disease 5 | 238
Dull intelligence 5 | 645
Hypercholesterolemia 5 | 44
Hypertension 5 | 396
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Neurodegenerative disease 5 | 414
Poor school performance 5 | 645
Splenomegaly 5 | 190
acute quadriplegic myopathy 5 | 1,158
astrocytoma 5 | 1,146
breast carcinoma 5 | 1,638
dermatomyositis 5 | 966
pituitary cancer 5 | 1,972
Atopic dermatitis 4 | 952
Breast cancer 4 | 3,578
Chemical and Drug Induced Liver Injury 4 | 195
Deglutition Disorders 4 | 132
Dementia 4 | 175
Duchenne muscular dystrophy 4 | 601
Dystonia 4 | 164
Hyperlipidemia 4 | 43
Hypertensive disease 4 | 292
Kidney disease 4 | 430
Liver Cirrhosis, Experimental 4 | 769
Pick disease 4 | 1,894
Seizures 4 | 596
Serum cholesterol raised 4 | 22
Simpson-Golabi-Behmel syndrome 4 | 19
colon cancer 4 | 1,478
nasopharyngeal carcinoma 4 | 1,058
primary pancreatic ductal adenocarcinoma 4 | 1,109
progressive supranuclear palsy 4 | 676
Cardiovascular Diseases 3 | 59
Cholestasis 3 | 155
Epilepsy 3 | 792
Heart disease 3 | 306
Lung Neoplasms 3 | 232
Neuropathy 3 | 261
Prostatic Neoplasms 3 | 495
Toxic encephalopathy 3 | 141
Vascular disease 3 | 319
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
cutaneous lupus erythematosus 3 | 1,057
fibroadenoma 3 | 559
non-small cell lung cancer 3 | 2,890
pediatric high grade glioma 3 | 1,064
primary Sjogren syndrome 3 | 735
ulcerative colitis 3 | 1,819

Tissue

Digestive Tract 43 | 17,369
Endocrine System 43 | 18,159
Female tissues 43 | 17,400
Blood and immune system 42 | 16,909
Liver and Pancreas 42 | 16,750
Skin and soft tissues 42 | 17,230
Urinary Tract 42 | 16,678
Male tissues 41 | 17,142
Nervous System 39 | 16,725
Respiratory system 39 | 16,393
Cardiovascular System 35 | 15,192

Target Family

Non-IDG 38 | 12,091
Enzyme 3 | 4,145
Transporter 2 | 473
Nuclear Receptor 1 | 48

GO Function

cholesterol binding 44 | 44
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Niemann-Pick C1 protein NPC1 Tbio Non-IDG -2.71962 551.3 284
Sterol regulatory element-binding protein cleavage-activating protein SCAP Tbio Non-IDG -1.85010 73.9 172
Oxysterol-binding protein-related protein 10 OSBPL10 Tbio Non-IDG -0.69897 6.13 127
Translocator protein 2 TSPO2 Tdark Non-IDG -0.55764 3.78 3
Apolipoprotein A-V APOA5 Tbio Non-IDG -2.58826 425.0 481
Steroidogenic acute regulatory protein, mitochondrial STAR Tbio Non-IDG -2.84388 738.4 199
StAR-related lipid transfer protein 6 STARD6 Tbio Non-IDG -1.03409 11.2 62
Myelin P2 protein PMP2 Tbio Non-IDG -2.15694 138.4 116
Oxysterol-binding protein-related protein 8 OSBPL8 Tbio Non-IDG -1.07071 12.9 77
Oxysterol-binding protein-related protein 7 OSBPL7 Tbio Non-IDG -0.33412 2.31 32