Development Level

Tbio 35 | 11,651
Tclin 13 | 612
Tdark 6 | 6,593
Tchem 1 | 1,388

Collection

Ion Channel: IDG Consortium (T... 16 | 99
RFA-RM-18-021 15 | 328

IMPC Phenotype

abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal heart morphology 1 | 162
abnormal testis morphology 1 | 43
decreased lymphocyte cell numb... 1 | 83
decreased red blood cell distr... 1 | 41
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
hydrometra 1 | 53
improved glucose tolerance 1 | 79
increased body length 1 | 32
increased fasted circulating g... 1 | 76
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499
small superior vagus ganglion 1 | 74
small testis 1 | 58

Disease

Carcinoma 39 | 11,493
psoriasis 24 | 6,694
osteosarcoma 22 | 7,950
medulloblastoma, large-cell 21 | 6,241
ovarian cancer 21 | 8,520
atypical teratoid / rhabdoid tumor 18 | 5,112
ependymoma 17 | 4,679
glioblastoma 16 | 5,792
cystic fibrosis 15 | 1,696
pancreatic cancer 15 | 2,398
malignant mesothelioma 14 | 3,232
oligodendroglioma 14 | 2,850
Astrocytoma, Pilocytic 13 | 3,081
Breast cancer 13 | 3,578
Epilepsy 13 | 792
Kidney cancer 13 | 2,613
Schizophrenia 13 | 1,160
lung cancer 13 | 4,740
primitive neuroectodermal tumor 13 | 3,035
adult high grade glioma 12 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
lung carcinoma 12 | 2,843
Anxiety 11 | 136
General anesthesia 11 | 53
Insomnia 11 | 20
Tonic-clonic epilepsy 11 | 47
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
lung adenocarcinoma 11 | 2,716
Pendred Syndrome 10 | 22
astrocytic glioma 10 | 2,597
group 3 medulloblastoma 10 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
Alcoholic Intoxication, Chronic 9 | 289
Diastrophic dysplasia 9 | 21
Sedation as Adjunct to Anesthesia 9 | 15
non-small cell lung cancer 9 | 2,890
ulcerative colitis 9 | 1,819
Pick disease 8 | 1,894
group 4 medulloblastoma 8 | 1,855
interstitial cystitis 8 | 2,312
Autosomal recessive predisposition 7 | 1,442
Bipolar Disorder 7 | 666
Nephrolithiasis 7 | 56
Nonsyndromic deafness 7 | 142
active Crohn's disease 7 | 922
colon cancer 7 | 1,478
nasopharyngeal carcinoma 7 | 1,058
subependymal giant cell astrocytoma 7 | 2,287
Autistic Disorder 6 | 364
Intellectual disability 6 | 1,016
esophageal adenocarcinoma 6 | 737
invasive ductal carcinoma 6 | 2,951
tuberculosis 6 | 2,010
Alcohol dependence 5 | 107
Alcohol withdrawal delirium 5 | 11
Alcohol withdrawal syndrome 5 | 20
Benzodiazepine Induced Sedation 5 | 8
Benzodiazepine Maintained Anesthesia 5 | 8
Benzodiazepine Toxicity 5 | 8
Cognitive delay 5 | 608
Conscious sedation 5 | 10
Diarrhea 5 | 253
Dull intelligence 5 | 645
Feeling agitated 5 | 7
Global developmental delay 5 | 608
Induce Anterograde Amnesia 5 | 9
Local anesthesia 5 | 40
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental and motor retardation 5 | 608
Mental deficiency 5 | 645
Muscle hypotonia 5 | 571
Poor school performance 5 | 645
Preoperative Anxiety 5 | 9
Sedation 5 | 11
Sedation in Intubated Patients 5 | 8
Spasticity 5 | 26
Status Epilepticus 5 | 98
Tetanus 5 | 68
active ulcerative colitis 5 | 764
ductal carcinoma in situ 5 | 1,745
non primary Sjogren syndrome sicca 5 | 891
pituitary cancer 5 | 1,972
primary pancreatic ductal adenocarcinoma 5 | 1,109
Constipation 4 | 181
Degenerative polyarthritis 4 | 115
Irritable bowel syndrome 4 | 60
Mood Disorders 4 | 184
Multiple myeloma 4 | 1,332
Osteopetrosis 4 | 43
Panic disorder 4 | 61
Recurrent respiratory infections 4 | 141
Schizoaffective Disorder 4 | 55
adrenocortical carcinoma 4 | 1,428
breast carcinoma 4 | 1,638
cutaneous lupus erythematosus 4 | 1,057
diabetes mellitus 4 | 1,728
gastric carcinoma 4 | 807
hepatocellular carcinoma 4 | 547
pancreatic carcinoma 4 | 562

Tissue

Endocrine System 53 | 18,159
Skin and soft tissues 52 | 17,230
Female tissues 51 | 17,400
Blood and immune system 50 | 16,909
Digestive Tract 50 | 17,369
Male tissues 49 | 17,142
Nervous System 49 | 16,725
Liver and Pancreas 45 | 16,750
Urinary Tract 45 | 16,678
Respiratory system 42 | 16,393
Cardiovascular System 37 | 15,192

Target Family

Ion Channel 42 | 344
Transporter 10 | 473
Non-IDG 3 | 12,091

GO Function

chloride channel activity 55 | 55
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein tweety homolog 3 TTYH3 Tbio Ion Channel -0.17609 1.56 17
Chloride intracellular channel protein 4 CLIC4 Tbio Ion Channel -1.81713 70.5 221
H(+)/Cl(-) exchange transporter 5 CLCN5 Tbio Ion Channel -2.32606 225.3 156
H(+)/Cl(-) exchange transporter 7 CLCN7 Tbio Ion Channel -1.96458 100.7 151
Cystic fibrosis transmembrane conductance regulator CFTR Tclin Ion Channel -3.79415 6397.4 472
Gamma-aminobutyric acid receptor subunit alpha-6 GABRA6 Tclin Ion Channel -1.30795 19.3 145
Gamma-aminobutyric acid receptor subunit alpha-3 GABRA3 Tclin Ion Channel -1.53765 32.9 135
Gamma-aminobutyric acid receptor subunit delta GABRD Tclin Ion Channel -1.47560 28.7 205
Phospholemman FXYD1 Tbio Ion Channel -2.73447 552.2 207
Gamma-aminobutyric acid receptor subunit beta-2 GABRB2 Tclin Ion Channel -1.49466 30.4 257