Development Level

Tbio 30 | 11,651
Tdark 12 | 6,593
Tchem 7 | 1,388
Tclin 4 | 612

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal kidney morphology 2 | 65
abnormal lens morphology 2 | 81
decreased bone mineral density 2 | 126
decreased circulating chloride... 2 | 30
decreased circulating glucose ... 2 | 126
embryonic lethality prior to t... 2 | 278
small kidney 2 | 16
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal embryo size 1 | 220
abnormal placenta size 1 | 20
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal urinary bladder morph... 1 | 11
abnormal vertebral arch morpho... 1 | 9
cataract 1 | 92
convulsive seizures 1 | 13
cystolithiasis 1 | 3
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating free fat... 1 | 31
decreased exploration in new e... 1 | 11
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased red blood cell distr... 1 | 41
decreased threshold for audito... 1 | 26
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged kidney 1 | 14
enlarged spleen 1 | 41
enlarged urinary bladder 1 | 8
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating potassiu... 1 | 29
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
pale liver 1 | 6
pale yolk sac 1 | 25
polycystic kidney 1 | 15
preweaning lethality, incomple... 1 | 499
prolonged PR interval 1 | 15
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

Carcinoma 35 | 11,493
ovarian cancer 26 | 8,520
osteosarcoma 23 | 7,950
psoriasis 23 | 6,694
glioblastoma 20 | 5,792
ependymoma 19 | 4,679
medulloblastoma, large-cell 18 | 6,241
lung cancer 17 | 4,740
atypical teratoid / rhabdoid tumor 15 | 5,112
group 3 medulloblastoma 15 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
invasive ductal carcinoma 14 | 2,951
astrocytic glioma 13 | 2,597
lung carcinoma 13 | 2,843
non-small cell lung cancer 13 | 2,890
subependymal giant cell astrocytoma 13 | 2,287
Kidney cancer 12 | 2,613
Astrocytoma, Pilocytic 11 | 3,081
Breast cancer 11 | 3,578
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
lung adenocarcinoma 11 | 2,716
malignant mesothelioma 11 | 3,232
oligodendroglioma 11 | 2,850
pancreatic cancer 11 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
adult high grade glioma 10 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
primitive neuroectodermal tumor 10 | 3,035
adrenocortical carcinoma 9 | 1,428
cystic fibrosis 9 | 1,696
Cancer 7 | 2,499
Hypertension 7 | 396
Seizures 7 | 596
colon cancer 7 | 1,478
interstitial cystitis 7 | 2,312
ulcerative colitis 7 | 1,819
Autosomal recessive predisposition 6 | 1,442
Epilepsy 6 | 792
Schizophrenia 6 | 1,160
aldosterone-producing adenoma 6 | 665
ductal carcinoma in situ 6 | 1,745
tuberculosis 6 | 2,010
Atopic dermatitis 5 | 952
Obesity 5 | 678
Pick disease 5 | 1,894
cutaneous lupus erythematosus 5 | 1,057
dermatomyositis 5 | 966
esophageal adenocarcinoma 5 | 737
nephrosclerosis 5 | 333
Alzheimer's disease 4 | 658
Bipolar Disorder 4 | 666
Diarrhea 4 | 253
Endometriosis 4 | 540
Liver Cirrhosis, Experimental 4 | 769
Multiple Sclerosis 4 | 540
Osteoporosis 4 | 363
Prostatic Neoplasms 4 | 495
Toxic encephalopathy 4 | 141
fibroadenoma 4 | 559
gastric carcinoma 4 | 807
inflammatory breast cancer 4 | 286
pediatric high grade glioma 4 | 1,064
pituitary cancer 4 | 1,972
Abdominal Pain 3 | 98
Acquired metabolic disease 3 | 336
Anemia 3 | 365
Arthralgia 3 | 90
Arthritis 3 | 290
Atherosclerosis 3 | 291
Blepharoptosis 3 | 231
Carcinoma, Renal Cell 3 | 124
Cardiovascular system disease 3 | 246
Cerebrovascular disease 3 | 238
Coronary artery disease 3 | 268
Dementia 3 | 175
Failure to gain weight 3 | 365
Parkinson's disease 3 | 392
Pediatric failure to thrive 3 | 365
Renal Cell Carcinoma 3 | 214
Rheumatoid arthritis 3 | 1,191
active Crohn's disease 3 | 922
acute quadriplegic myopathy 3 | 1,158
chronic rhinosinusitis 3 | 512
diabetes mellitus 3 | 1,728
medulloblastoma 3 | 720
progressive supranuclear palsy 3 | 676
spina bifida 3 | 1,074
Amphetamine-Related Disorders 2 | 74
Attention deficit hyperactivity disorder 2 | 278
Byzanthine arch palate 2 | 194
Chronic obstructive pulmonary disease 2 | 184
Depressive disorder 2 | 409
Kidney disease 2 | 430
Mental Depression 2 | 333
Neuroblastoma 2 | 80
Polycystic ovary syndrome 2 | 360
astrocytoma 2 | 1,146
breast carcinoma 2 | 1,638
mucosa-associated lymphoid tissue lymphoma 2 | 484
primary pancreatic ductal adenocarcinoma 2 | 1,109

Tissue

Endocrine System 50 | 18,159
Skin and soft tissues 50 | 17,230
Blood and immune system 49 | 16,909
Digestive Tract 49 | 17,369
Female tissues 49 | 17,400
Liver and Pancreas 49 | 16,750
Male tissues 49 | 17,142
Nervous System 49 | 16,725
Urinary Tract 49 | 16,678
Respiratory system 48 | 16,393
Cardiovascular System 44 | 15,192

Target Family

Enzyme 33 | 4,145
Non-IDG 16 | 12,091
Transporter 2 | 473
Epigenetic 1 | 242
Kinase 1 | 634

GO Function

catalytic activity 53 | 53
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Echinoderm microtubule-associated protein-like 5 EML5 Tdark Non-IDG -0.47268 3.14 28
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H PIGH Tbio Enzyme -1.19063 13.0 116
Poly [ADP-ribose] polymerase 3 PARP3 Tclin Enzyme -1.66230 41.9 193
Radical S-adenosyl methionine domain-containing protein 2 RSAD2 Tbio Non-IDG -1.99883 103.3 117
Acid ceramidase ASAH1 Tchem Enzyme -2.94716 848.0 203
Estradiol 17-beta-dehydrogenase 1 HSD17B1 Tchem Enzyme -2.36315 220.8 198
Inositol-tetrakisphosphate 1-kinase ITPK1 Tbio Kinase -1.38434 24.8 201
N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 DDAH2 Tbio Enzyme -2.11860 122.5 183
Hedgehog-interacting protein HHIP Tbio Non-IDG -1.83526 65.4 193
Protein-glutamine gamma-glutamyltransferase E TGM3 Tchem Enzyme -2.69033 481.2 236