Development Level

Tbio 4 | 11,445
Tdark 3 | 6,588
Tchem 1 | 1,598

IMPC Phenotype

enlarged heart 1 | 210
preweaning lethality, complete... 1 | 979

Disease

Carcinoma 4 | 11,493
ovarian cancer 4 | 8,520
Epilepsy 3 | 792
Acidosis, Lactic 2 | 97
Autosomal recessive predisposition 2 | 1,442
Brain Edema 2 | 50
Cerebellar Ataxia 2 | 304
Cerebral Edema 2 | 30
Classic Maple Syrup Urine Disease 2 | 3
Comatose 2 | 56
Dull intelligence 2 | 645
Elevated plasma branched chain amino acids 2 | 3
Feeding difficulties in infancy 2 | 175
Hallucinations 2 | 34
Hallucinations, Sensory 2 | 33
Hypoglycemia 2 | 152
Intellectual disability 2 | 1,016
Intermediate Maple Syrup Urine Disease 2 | 4
Intermittent Maple Syrup Urine Disease 2 | 3
Ketonemia 2 | 11
Ketosis 2 | 11
Lactic acidemia 2 | 95
Lethargy 2 | 77
Low intelligence 2 | 645
Maple Syrup Urine Disease, Thiamine Responsive 2 | 3
Maple syrup urine disease 2 | 24
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Muscle Hypertonia 2 | 88
Muscle hypotonia 2 | 571
Osteoporosis 2 | 363
Pancreatitis 2 | 123
Poor school performance 2 | 645
Renal oncocytoma 2 | 22
Seizures 2 | 596
Vomiting 2 | 116
abnormal growth 2 | 26
glioblastoma 2 | 5,792
interstitial cystitis 2 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
invasive ductal carcinoma 2 | 2,951
lung cancer 2 | 4,740
lung carcinoma 2 | 2,843
osteosarcoma 2 | 7,950
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
Acquired metabolic disease 1 | 336
Acute cystitis 1 | 35
Anorexia nervosa 1 | 80
Arthropathy 1 | 43
Astrocytoma, Pilocytic 1 | 3,081
Atopic dermatitis 1 | 952
Bacteriuria 1 | 8
Bipolar Disorder 1 | 666
Bipolar I disorder 1 | 23
Breast cancer 1 | 3,578
Carcinoma, Renal Cell 1 | 124
Chemical and Drug Induced Liver Injury 1 | 195
Chondrocalcinosis 1 | 9
Congenital adrenal insufficiency 1 | 7
Crohn's disease 1 | 321
Gout 1 | 106
Hyperuricemia 1 | 49
IMAGe syndrome 1 | 8
Ichthyosis 1 | 56
L-2-hydroxyglutaric aciduria 1 | 8
Liver neoplasms 1 | 130
Melanoma 1 | 711
Multiple myeloma 1 | 1,332
Peritonitis 1 | 43
Pyuria 1 | 5
Renal Cell Carcinoma 1 | 214
Stiff-Person syndrome 1 | 12
Synovitis 1 | 78
Urethral syndrome 1 | 2
X-linked cerebral adrenoleukodystrophy 1 | 116
astrocytoma 1 | 1,146
atypical teratoid / rhabdoid tumor 1 | 5,112
breast carcinoma 1 | 1,638
ductal carcinoma in situ 1 | 1,745
ependymoma 1 | 4,679
group 3 medulloblastoma 1 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 1 | 2,955
lung adenocarcinoma 1 | 2,716
malignant mesothelioma 1 | 3,232
medulloblastoma 1 | 720
medulloblastoma, large-cell 1 | 6,241
non-small cell lung cancer 1 | 2,890
pituitary cancer 1 | 1,972
posterior fossa group A ependymoma 1 | 468
progressive supranuclear palsy 1 | 676
psoriasis 1 | 6,694
tuberculosis 1 | 2,010

Tissue

Blood and immune system 7 | 16,909
Digestive Tract 7 | 17,369
Endocrine System 7 | 18,159
Female tissues 7 | 17,400
Male tissues 7 | 17,142
Skin and soft tissues 7 | 17,230
Cardiovascular System 6 | 15,192
Liver and Pancreas 6 | 16,750
Nervous System 6 | 16,725
Respiratory system 6 | 16,393
Urinary Tract 6 | 16,678

Target Family

Enzyme 8 | 4,145

GO Function

carboxy-lyase activity 8 | 8
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

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