Development Level

Tbio 120 | 10,625
Tdark 31 | 7,003
Tchem 26 | 1,890
Tclin 3 | 602

Collection

Eligible Ion Channel Proteins 2 | 117
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 4 | 633
abnormal lens morphology 2 | 73
decreased circulating glucose ... 2 | 121
decreased total body fat amoun... 2 | 186
embryonic lethality prior to o... 2 | 148
embryonic lethality prior to t... 2 | 187
increased effector memory CD8-... 2 | 14
short tibia 2 | 82
abnormal QRS complex 1 | 25
abnormal embryo size 1 | 112
abnormal forebrain development 1 | 18
abnormal heart morphology 1 | 51
abnormal hindbrain development 1 | 24
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal sleep behavior 1 | 63
abnormal spinal cord morpholog... 1 | 8
abnormal spleen morphology 1 | 36
abnormal tooth morphology 1 | 24
abnormal vitreous body morphol... 1 | 7
abnormal whole-body plethysmog... 1 | 4
convulsive seizures 1 | 11
decreased KLRG1-positive NK ce... 1 | 9
decreased Ly6C low monocyte nu... 1 | 23
decreased body weight 1 | 174
decreased circulating alanine ... 1 | 53
decreased circulating fructosa... 1 | 31
decreased circulating insulin ... 1 | 75
decreased circulating lactate ... 1 | 1
decreased circulating phosphat... 1 | 15
decreased circulating serum al... 1 | 79
decreased circulating triglyce... 1 | 83
decreased grip strength 1 | 123
decreased lean body mass 1 | 195
decreased prepulse inhibition 1 | 52
decreased pulmonary respirator... 1 | 4
decreased spleen weight 1 | 13
decreased startle reflex 1 | 48
decreased threshold for audito... 1 | 32
enlarged heart 1 | 111
enlarged lymph nodes 1 | 27
female infertility 1 | 34
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
increased Ly6C high monocyte n... 1 | 12
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating choleste... 1 | 53
increased circulating fructosa... 1 | 11
increased neutrophil cell numb... 1 | 15
increased or absent threshold ... 1 | 128
increased red blood cell distr... 1 | 21
increased spleen weight 1 | 3
increased tidal volume 1 | 1
small adrenal glands 1 | 15
small superior vagus ganglion 1 | 20
tremors 1 | 34
vertebral fusion 1 | 23
vertebral transformation 1 | 12

Disease

osteosarcoma 73 | 7,933
ovarian cancer 69 | 8,484
psoriasis 68 | 6,685
glioblastoma 54 | 5,572
lung adenocarcinoma 45 | 2,713
lung cancer 43 | 4,466
lung carcinoma 42 | 2,844
medulloblastoma, large-cell 42 | 6,234
intraductal papillary-mucinous adenoma (IPMA) 41 | 2,956
pilocytic astrocytoma 41 | 3,086
interstitial cystitis 39 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 39 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 38 | 3,289
invasive ductal carcinoma 37 | 2,950
non-small cell lung cancer 36 | 2,798
pancreatic cancer 33 | 2,300
Cancer 30 | 2,346
pituitary cancer 29 | 1,972
atypical teratoid / rhabdoid tumor 28 | 4,369
tuberculosis 28 | 1,557
Breast cancer 27 | 3,094
pancreatic ductal adenocarcinoma liver metastasis 26 | 1,795
malignant mesothelioma 25 | 3,162
posterior fossa group A ependymoma 25 | 1,511
adult high grade glioma 24 | 2,148
subependymal giant cell astrocytoma 24 | 2,287
Carcinoma 23 | 2,147
cutaneous lupus erythematosus 23 | 1,056
ductal carcinoma in situ 22 | 1,745
oligodendroglioma 22 | 2,849
pediatric high grade glioma 22 | 2,712
diabetes mellitus 21 | 1,663
ulcerative colitis 21 | 2,087
astrocytoma 20 | 1,493
colon cancer 20 | 1,475
cystic fibrosis 20 | 1,665
group 4 medulloblastoma 20 | 1,875
astrocytic glioma 18 | 2,241
breast carcinoma 18 | 1,614
Atopic dermatitis 17 | 944
group 3 medulloblastoma 16 | 2,254
mucosa-associated lymphoid tissue lymphoma 16 | 480
primitive neuroectodermal tumor 16 | 3,031
Rheumatoid Arthritis 15 | 1,160
Pick disease 14 | 1,893
active Crohn's disease 14 | 918
primary pancreatic ductal adenocarcinoma 14 | 1,271
adrenocortical carcinoma 12 | 1,427
ependymoma 12 | 2,514
gastric carcinoma 12 | 832
juvenile dermatomyositis 12 | 1,189
primary Sjogren syndrome 12 | 789
Multiple myeloma 11 | 1,327
esophageal adenocarcinoma 11 | 737
nasopharyngeal carcinoma 11 | 1,056
Waldenstrons macroglobulinemia 10 | 765
dermatomyositis 10 | 933
non-small cell lung carcinoma 10 | 413
chronic lymphosyte leukemia 9 | 232
pancreatic carcinoma 9 | 567
posterior fossa group B ependymoma 9 | 1,530
sonic hedgehog group medulloblastoma 9 | 1,482
Asthma 8 | 349
Multiple Sclerosis 8 | 498
active ulcerative colitis 8 | 477
acute quadriplegic myopathy 8 | 1,157
atypical teratoid/rhabdoid tumor 8 | 1,095
medulloblastoma 8 | 1,524
non primary Sjogren syndrome sicca 8 | 840
tuberculosis and treatment for 3 months 8 | 327
Down syndrome 7 | 548
Duchenne muscular dystrophy 7 | 602
Human immunodeficiency virus infectious disease 7 | 92
IGA Glomerulonephritis 7 | 454
Kidney disease 7 | 396
Schizophrenia 7 | 501
facioscapulohumeral dystrophy 7 | 286
fibroadenoma 7 | 557
head and neck cancer and chronic obstructive pulmonary disease 7 | 237
spina bifida 7 | 1,064
Atherosclerosis 6 | 275
Coronary artery disease 6 | 240
Hypersensitivity reaction type II disease 6 | 235
Influenza 6 | 142
gastric cancer 6 | 430
nephrosclerosis 6 | 329
sarcoidosis 6 | 358
tuberculosis and treatment for 6 months 6 | 686
Barrett's esophagus 5 | 183
Heart disease 5 | 279
Neuropathy 5 | 210
Pneumonia 5 | 133
Spontaneous abortion 5 | 108
Tetanus 5 | 66
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 499
chronic rhinosinusitis 5 | 512
hepatocellular carcinoma 5 | 532
interstitial lung disease 5 | 291
periodontitis 5 | 269
progressive supranuclear palsy 5 | 674

Tissue

Endocrine System 176 | 18,512
Nervous System 176 | 18,561
Digestive Tract 175 | 18,473
Female tissues 175 | 18,647
Urinary Tract 175 | 18,444
Blood and immune system 174 | 17,995
Cardiovascular System 174 | 17,958
Skin and soft tissues 173 | 18,115
Liver and Pancreas 172 | 18,136
Male tissues 169 | 17,969
Respiratory system 168 | 17,484

Target Family

Non-IDG 129 | 11,971
Enzyme 45 | 4,146
GPCR 3 | 406
Ion Channel 2 | 341
Kinase 1 | 634

GO Function

carbohydrate binding 180 | 180
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Vesicular integral-membrane protein VIP36 LMAN2 Tbio Non-IDG -1.35463 24.9 101
Killer cell lectin-like receptor subfamily B member 1 KLRB1 Tbio Non-IDG -2.39953 313.9 488
Sialoadhesin SIGLEC1 Tbio Non-IDG -2.22508 195.6 309
Acidic mammalian chitinase CHIA Tchem Enzyme -2.59382 419.7 126
CD302 antigen CD302 Tbio Non-IDG -1.66778 46.5 120
Pulmonary surfactant-associated protein A2 SFTPA2 Tbio Non-IDG -2.31137 207.3 90
NKG2-C type II integral membrane protein KLRC2 Tbio Non-IDG -1.86834 75.2 128
NKG2-D type II integral membrane protein KLRK1 Tbio Non-IDG -1.48442 31.1 337
NKG2-A/NKG2-B type II integral membrane protein KLRC1 Tbio Non-IDG -2.40441 255.8 351