Development Level

Tbio 135 | 11,651
Tdark 24 | 6,593
Tchem 15 | 1,388
Tclin 4 | 612

Collection

Ion Channel: IDG Consortium (T... 2 | 99
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 5 | 979
decreased vertical activity 4 | 208
decreased total body fat amoun... 3 | 207
increased bone mineral content 3 | 108
abnormal bone structure 2 | 187
abnormal eye morphology 2 | 68
abnormal seminal vesicle morph... 2 | 114
decreased circulating glucose ... 2 | 126
decreased circulating insulin ... 2 | 76
decreased grip strength 2 | 116
decreased startle reflex 2 | 75
embryonic lethality prior to o... 2 | 239
increased lean body mass 2 | 172
preweaning lethality, incomple... 2 | 499
small superior vagus ganglion 2 | 74
abnormal QT variability 1 | 10
abnormal embryo size 1 | 220
abnormal forebrain development 1 | 20
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal midbrain development 1 | 20
abnormal nail morphology 1 | 8
abnormal neural tube closure 1 | 46
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
absent prostate gland 1 | 1
absent seminal vesicle 1 | 4
absent testes 1 | 6
aorta dilation 1 | 3
convulsive seizures 1 | 13
decreased cardiac muscle contr... 1 | 11
decreased circulating alkaline... 1 | 46
decreased circulating fructosa... 1 | 30
decreased circulating phosphat... 1 | 27
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased coping response 1 | 8
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased prepulse inhibition 1 | 82
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
female infertility 1 | 60
hydrometra 1 | 53
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased bone mineral density 1 | 72
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased circulating serum al... 1 | 22
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
prolonged QRS complex duration 1 | 8
prolonged QT interval 1 | 38
small adrenal glands 1 | 16
vertebral fusion 1 | 23

Disease

Carcinoma 109 | 11,493
osteosarcoma 71 | 7,950
ovarian cancer 67 | 8,520
psoriasis 66 | 6,694
glioblastoma 55 | 5,792
lung cancer 45 | 4,740
lung adenocarcinoma 43 | 2,716
medulloblastoma, large-cell 42 | 6,241
Astrocytoma, Pilocytic 41 | 3,081
lung carcinoma 40 | 2,843
interstitial cystitis 39 | 2,312
non-small cell lung cancer 39 | 2,890
intraductal papillary-mucinous adenoma (IPMA) 38 | 2,955
adult high grade glioma 37 | 3,801
ependymoma 36 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 36 | 2,989
tuberculosis 36 | 2,010
atypical teratoid / rhabdoid tumor 35 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 35 | 3,291
invasive ductal carcinoma 35 | 2,951
Cancer 31 | 2,499
Kidney cancer 31 | 2,613
pancreatic cancer 30 | 2,398
Breast cancer 29 | 3,578
pituitary cancer 29 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 27 | 1,962
group 3 medulloblastoma 25 | 4,104
malignant mesothelioma 25 | 3,232
cutaneous lupus erythematosus 23 | 1,057
oligodendroglioma 23 | 2,850
subependymal giant cell astrocytoma 23 | 2,287
astrocytic glioma 22 | 2,597
ductal carcinoma in situ 22 | 1,745
group 4 medulloblastoma 22 | 1,855
cystic fibrosis 21 | 1,696
colon cancer 20 | 1,478
breast carcinoma 18 | 1,638
diabetes mellitus 18 | 1,728
ulcerative colitis 18 | 1,819
Atopic dermatitis 17 | 952
primitive neuroectodermal tumor 17 | 3,035
astrocytoma 16 | 1,146
mucosa-associated lymphoid tissue lymphoma 16 | 484
Pick disease 14 | 1,894
Rheumatoid arthritis 14 | 1,191
active Crohn's disease 13 | 922
adrenocortical carcinoma 13 | 1,428
Multiple myeloma 12 | 1,332
Waldenstrons macroglobulinemia 11 | 765
esophageal adenocarcinoma 11 | 737
juvenile dermatomyositis 11 | 1,187
nasopharyngeal carcinoma 11 | 1,058
non primary Sjogren syndrome sicca 11 | 891
Autosomal recessive predisposition 10 | 1,442
Melanoma 10 | 711
active ulcerative colitis 10 | 764
dermatomyositis 10 | 966
gastric carcinoma 10 | 807
primary pancreatic ductal adenocarcinoma 10 | 1,109
Liver cancer 9 | 604
Multiple Sclerosis 9 | 540
pediatric high grade glioma 9 | 1,064
primary Sjogren syndrome 9 | 735
Asthma 8 | 385
Liver Cirrhosis, Experimental 8 | 769
acute quadriplegic myopathy 8 | 1,158
pancreatic carcinoma 8 | 562
Down syndrome 7 | 499
Duchenne muscular dystrophy 7 | 601
Epilepsy 7 | 792
Human immunodeficiency virus infectious disease 7 | 138
Hypersensitivity reaction type II disease 7 | 253
Schizophrenia 7 | 1,160
Skin cancer 7 | 469
chronic lymphosyte leukemia 7 | 204
facioscapulohumeral dystrophy 7 | 288
fibroadenoma 7 | 559
head and neck cancer and chronic obstructive pulmonary disease 7 | 239
posterior fossa group A ependymoma 7 | 468
spina bifida 7 | 1,074
Atherosclerosis 6 | 291
Coronary artery disease 6 | 268
Heart disease 6 | 306
Influenza 6 | 142
Kidney disease 6 | 430
Muscle hypotonia 6 | 571
Neuropathy 6 | 261
gastric cancer 6 | 459
nephrosclerosis 6 | 333
non-small cell lung carcinoma 6 | 317
progressive supranuclear palsy 6 | 676
sarcoidosis 6 | 370
Dull intelligence 5 | 645
Low intelligence 5 | 645
Mental deficiency 5 | 645
Poor school performance 5 | 645
acute myeloid leukemia 5 | 783
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 510
chronic rhinosinusitis 5 | 512
periodontitis 5 | 293

Tissue

Female tissues 171 | 17,400
Skin and soft tissues 171 | 17,230
Digestive Tract 169 | 17,369
Endocrine System 169 | 18,159
Blood and immune system 167 | 16,909
Liver and Pancreas 165 | 16,750
Male tissues 163 | 17,142
Urinary Tract 159 | 16,678
Respiratory system 158 | 16,393
Nervous System 152 | 16,725
Cardiovascular System 136 | 15,192

Target Family

Non-IDG 128 | 12,091
Enzyme 43 | 4,145
GPCR 3 | 408
Ion Channel 2 | 344
Kinase 2 | 634

GO Function

carbohydrate binding 178 | 178
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Galectin-2 LGALS2 Tbio Non-IDG -1.12300 13.4 172
C-type lectin domain family 19 member A CLEC19A Tdark Non-IDG -0.20713 1.29 3
C-type lectin domain family 18 member B CLEC18B Tdark Non-IDG 0.35 0.31 6
Polypeptide N-acetylgalactosaminyltransferase 3 GALNT3 Tbio Enzyme -2.80894 644.1 124
C-type lectin domain family 6 member A CLEC6A Tbio Non-IDG -1.54098 33.3 328
C-type lectin domain family 9 member A CLEC9A Tbio Non-IDG -1.64671 48.1 232
C-type lectin domain family 5 member A CLEC5A Tbio Non-IDG -1.56055 41.9 139
Probable polypeptide N-acetylgalactosaminyltransferase 8 GALNT8 Tbio Enzyme -0.64755 3.62 54
Killer cell lectin-like receptor subfamily G member 2 KLRG2 Tdark Non-IDG -0.06695 1.11 58
Intelectin-2 ITLN2 Tbio Non-IDG -0.88188 7.69 88