Development Level

Tchem 16 | 1,890
Tbio 6 | 10,625

Collection

Eligible Kinase Proteins 6 | 134

IMPC Term

abnormal bone structure 1 | 131
abnormal gait 1 | 51
abnormal joint morphology 1 | 14
abnormal lumbar vertebrae morp... 1 | 6
abnormal optic disc morphology 1 | 10
decreased bone mineral content 1 | 157
decreased circulating iron lev... 1 | 25
decreased fasted circulating g... 1 | 49
increased circulating chloride... 1 | 43
increased circulating glucose ... 1 | 16
increased circulating iron lev... 1 | 25
increased circulating serum al... 1 | 25
short tibia 1 | 82

Disease

glioblastoma 15 | 5,572
medulloblastoma, large-cell 15 | 6,234
pilocytic astrocytoma 14 | 3,086
primitive neuroectodermal tumor 14 | 3,031
atypical teratoid / rhabdoid tumor 13 | 4,369
osteosarcoma 13 | 7,933
ependymoma 11 | 2,514
oligodendroglioma 11 | 2,849
medulloblastoma 9 | 1,524
ovarian cancer 9 | 8,484
pediatric high grade glioma 9 | 2,712
Pick disease 8 | 1,893
psoriasis 8 | 6,685
adult high grade glioma 6 | 2,148
astrocytic glioma 6 | 2,241
astrocytoma 6 | 1,493
malignant mesothelioma 6 | 3,162
subependymal giant cell astrocytoma 6 | 2,287
cystic fibrosis 5 | 1,665
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,289
lung carcinoma 5 | 2,844
posterior fossa group B ependymoma 5 | 1,530
ulcerative colitis 5 | 2,087
invasive ductal carcinoma 4 | 2,950
pancreatic cancer 4 | 2,300
pituitary cancer 4 | 1,972
Cancer 3 | 2,346
Cocaine-Related Disorders 3 | 88
Obesity 3 | 616
dermatomyositis 3 | 933
group 3 medulloblastoma 3 | 2,254
group 4 medulloblastoma 3 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,988
posterior fossa group A ependymoma 3 | 1,511
primary pancreatic ductal adenocarcinoma 3 | 1,271
Alzheimer's disease 2 | 644
Amyotrophic Lateral Sclerosis 2 | 431
COPD 2 | 113
Parkinson's disease 2 | 364
Renal Cell Carcinoma 2 | 199
Vascular disease 2 | 281
acute quadriplegic myopathy 2 | 1,157
diabetes mellitus 2 | 1,663
inflammatory breast cancer 2 | 404
lung cancer 2 | 4,466
non-small cell lung cancer 2 | 2,798
non-small cell lung carcinoma 2 | 413
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
progressive supranuclear palsy 2 | 674
sonic hedgehog group medulloblastoma 2 | 1,482
tuberculosis 2 | 1,557
tuberculosis and treatment for 3 months 2 | 327
Adenocarcinoma 1 | 115
Adenoid Cystic Carcinoma 1 | 99
Anorexia nervosa 1 | 59
Bipolar Disorder 1 | 266
Blood pressure finding 1 | 56
Brain Ischemia 1 | 87
Carcinoma, Transitional Cell 1 | 31
Cardiomyopathies 1 | 90
Cardiomyopathy 1 | 110
Cerebrovascular disease 1 | 231
Chronic Lymphocytic Leukemia 1 | 242
Degenerative polyarthritis 1 | 93
Epilepsy 1 | 346
Fetal alcohol spectrum disorder 1 | 6
Hyperalgesia 1 | 71
Juvenile arthritis 1 | 124
Leukemia, Myelocytic, Acute 1 | 113
Lissencephaly 1 | 61
Lung Neoplasms 1 | 171
MYELODYSPLASTIC SYNDROME 1 | 36
Melanoma 1 | 261
Metabolic syndrome X 1 | 155
Myocardial Ischemia 1 | 169
Nager acrofacial dysostosis 1 | 21
Neoplasm Metastasis 1 | 138
Peripheral Neuropathy 1 | 303
Periventricular nodular heterotopia 1 | 25
Polycystic Ovary Syndrome 1 | 332
Salivary Gland Neoplasms 1 | 45
Status Epilepticus 1 | 85
Substance-Related Disorders 1 | 114
Systemic arterial pressure 1 | 56
X-linked cerebral adrenoleukodystrophy 1 | 115
adrenocortical carcinoma 1 | 1,427
aldosterone-producing adenoma 1 | 664
atypical teratoid/rhabdoid tumor 1 | 1,095
breast carcinoma 1 | 1,614
colon cancer 1 | 1,475
facioscapulohumeral dystrophy 1 | 286
glioblastoma multiforme 1 | 347
interstitial lung disease 1 | 291
lung adenocarcinoma 1 | 2,713
nervous system disorder 1 | 53
sarcoidosis 1 | 358
spina bifida 1 | 1,064
substance-related disorder 1 | 105
tuberculosis and treatment for 6 months 1 | 686

Tissue

Blood and immune system 22 | 17,995
Cardiovascular System 22 | 17,958
Digestive Tract 22 | 18,473
Endocrine System 22 | 18,512
Female tissues 22 | 18,647
Liver and Pancreas 22 | 18,136
Male tissues 22 | 17,969
Nervous System 22 | 18,561
Skin and soft tissues 22 | 18,115
Urinary Tract 22 | 18,444
Respiratory system 21 | 17,484

Target Family

Kinase 21 | 634
Non-IDG 1 | 11,971

GO Function

calmodulin-dependent protein k... 22 | 22
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

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