Development Level

Tchem 19 | 1,598
Tbio 3 | 11,445

Collection

Kinase: IDG Consortium (Target... 6 | 125
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

abnormal bone structure 1 | 187
abnormal clavicle morphology 1 | 6
abnormal gait 1 | 69
abnormal joint morphology 1 | 23
abnormal optic disc morphology 1 | 10
decreased circulating iron lev... 1 | 32
decreased fasted circulating g... 1 | 65
decreased prepulse inhibition 1 | 82
hyperactivity 1 | 148
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30

Disease

ependymoma 19 | 4,679
glioblastoma 17 | 5,792
Carcinoma 16 | 11,493
medulloblastoma, large-cell 15 | 6,241
Astrocytoma, Pilocytic 14 | 3,081
atypical teratoid / rhabdoid tumor 14 | 5,112
primitive neuroectodermal tumor 14 | 3,035
adult high grade glioma 13 | 3,801
osteosarcoma 13 | 7,950
group 3 medulloblastoma 11 | 4,104
oligodendroglioma 11 | 2,850
astrocytic glioma 10 | 2,597
psoriasis 9 | 6,694
Pick disease 8 | 1,894
ovarian cancer 8 | 8,520
malignant mesothelioma 6 | 3,232
subependymal giant cell astrocytoma 6 | 2,287
cystic fibrosis 5 | 1,696
group 4 medulloblastoma 5 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
ulcerative colitis 5 | 1,819
lung carcinoma 4 | 2,843
pancreatic cancer 4 | 2,398
tuberculosis 4 | 2,010
Alcoholic Intoxication, Chronic 3 | 289
Cancer 3 | 2,499
Cocaine-Related Disorders 3 | 92
astrocytoma 3 | 1,146
dermatomyositis 3 | 966
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
invasive ductal carcinoma 3 | 2,951
pediatric high grade glioma 3 | 1,064
pituitary cancer 3 | 1,972
primary pancreatic ductal adenocarcinoma 3 | 1,109
substance-related disorder 3 | 162
Amyotrophic lateral sclerosis 2 | 451
COPD 2 | 118
Kidney cancer 2 | 2,613
Renal Cell Carcinoma 2 | 214
Schizophrenia 2 | 1,160
Vascular disease 2 | 319
acute quadriplegic myopathy 2 | 1,158
diabetes mellitus 2 | 1,728
lung cancer 2 | 4,740
non-small cell lung cancer 2 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
Adenocarcinoma 1 | 122
Adenoid Cystic Carcinoma 1 | 99
Arthritis, Juvenile 1 | 126
Carcinoma, Adenoid Cystic 1 | 99
Carcinoma, Renal Cell 1 | 124
Carcinoma, Transitional Cell 1 | 32
Cardiomyopathy 1 | 116
Depressive disorder 1 | 409
Fetal alcohol spectrum disorder 1 | 7
Hepatomegaly 1 | 285
Hyperalgesia 1 | 83
Hypertrophic Cardiomyopathy 1 | 117
Juvenile arthritis 1 | 126
Leukemia, Myelocytic, Acute 1 | 120
Leukemia, Myeloid, Acute 1 | 105
Liver Cirrhosis, Experimental 1 | 769
Lung Neoplasms 1 | 232
Lupus erythematosus 1 | 57
MYELODYSPLASTIC SYNDROME 1 | 53
Major Depressive Disorder 1 | 301
Melanoma 1 | 711
Mental Depression 1 | 333
Metabolic syndrome X 1 | 52
Mucoepidermoid carcinoma 1 | 26
Myelodysplastic Syndromes 1 | 26
Myocardial Ischemia 1 | 169
Nager acrofacial dysostosis 1 | 21
Neoplasm Metastasis 1 | 168
Nervous System Diseases 1 | 53
Ovarian Neoplasms 1 | 102
Parkinson's disease 1 | 392
Peripheral Neuropathy 1 | 134
Pilocytic astrocytoma 1 | 56
Polycystic ovary syndrome 1 | 360
Salivary Gland Neoplasms 1 | 46
Skin cancer 1 | 469
Status Epilepticus 1 | 98
Substance-Related Disorders 1 | 115
Unipolar Depression 1 | 250
X-linked cerebral adrenoleukodystrophy 1 | 116
adrenocortical carcinoma 1 | 1,428
breast carcinoma 1 | 1,638
colon cancer 1 | 1,478
cystic fibrosis and chronic rhinosinusitis 1 | 214
facioscapulohumeral dystrophy 1 | 288
inflammatory breast cancer 1 | 286
interstitial lung disease 1 | 298
medulloblastoma 1 | 720
nervous system disorder 1 | 53
non-small cell lung carcinoma 1 | 317
progressive supranuclear palsy 1 | 676
sarcoidosis 1 | 370
tuberculosis and treatment for 6 months 1 | 409

Tissue

Endocrine System 22 | 18,159
Nervous System 22 | 16,725
Skin and soft tissues 22 | 17,230
Blood and immune system 21 | 16,909
Digestive Tract 21 | 17,369
Female tissues 21 | 17,400
Liver and Pancreas 21 | 16,750
Male tissues 21 | 17,142
Respiratory system 20 | 16,393
Cardiovascular System 19 | 15,192
Urinary Tract 19 | 16,678

Target Family

Kinase 22 | 634

GO Function

calmodulin-dependent protein k... 22 | 22
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

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