Development Level

Tbio 116 | 11,445
Tchem 49 | 1,598
Tclin 19 | 613
Tdark 10 | 6,588

Collection

RFA-RM-18-021 10 | 328
Kinase: IDG Consortium (Target... 9 | 125
Kinase: IDG Consortium (Comple... 3 | 37
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, complete... 13 | 979
preweaning lethality, incomple... 8 | 499
abnormal bone structure 6 | 187
abnormal behavior 5 | 298
edema 5 | 59
hyperactivity 5 | 148
decreased body weight 4 | 161
increased or absent threshold ... 4 | 101
increased total body fat amoun... 4 | 134
abnormal embryo size 3 | 220
decreased bone mineral content 3 | 151
decreased leukocyte cell numbe... 3 | 73
embryonic lethality prior to t... 3 | 278
hemorrhage 3 | 23
increased erythrocyte cell num... 3 | 39
abnormal behavioral response t... 2 | 66
abnormal coat-hair pigmentatio... 2 | 64
abnormal digit morphology 2 | 10
abnormal gait 2 | 69
abnormal retina morphology 2 | 71
abnormal sleep behavior 2 | 70
decreased bone mineral density 2 | 126
decreased caudal vertebrae num... 2 | 53
decreased circulating amylase ... 2 | 28
decreased circulating choleste... 2 | 93
decreased circulating glucose ... 2 | 126
decreased circulating iron lev... 2 | 32
decreased circulating magnesiu... 2 | 13
decreased lean body mass 2 | 135
decreased prepulse inhibition 2 | 82
decreased total body fat amoun... 2 | 207
embryonic growth retardation 2 | 106
hypoactivity 2 | 132
improved glucose tolerance 2 | 79
increased circulating sodium l... 2 | 71
increased hematocrit 2 | 46
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 96
increased startle reflex 2 | 112
persistence of hyaloid vascula... 2 | 33
prenatal lethality prior to he... 2 | 87
short tibia 2 | 97
tremors 2 | 39
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal epididymis morphology 1 | 42
abnormal head morphology 1 | 10
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal locomotor activation 1 | 16
abnormal optic disc morphology 1 | 10
abnormal pericardium morpholog... 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal skin coloration 1 | 25
abnormal testis morphology 1 | 43
abnormal vibrissa morphology 1 | 25
abnormal vocalization 1 | 21
abnormal whole-body plethysmog... 1 | 4
absent pinna reflex 1 | 23
absent startle reflex 1 | 24
absent vibrissae 1 | 12
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
convulsive seizures 1 | 13
corneal opacity 1 | 32
decreased anxiety-related resp... 1 | 12
decreased body length 1 | 101
decreased circulating calcium ... 1 | 36
decreased circulating creatini... 1 | 39
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased exploration in new e... 1 | 11
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased red blood cell distr... 1 | 41
embryonic lethality prior to o... 1 | 239
enlarged epididymis 1 | 31
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating potassiu... 1 | 29
increased heart rate 1 | 23
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased vertical activity 1 | 24
limb grasping 1 | 41
prenatal lethality 1 | 28
shortened RR interval 1 | 17
small testis 1 | 58
stereotypic behavior 1 | 3
trunk curl 1 | 16

Disease

Carcinoma 155 | 11,493
glioblastoma 102 | 5,792
osteosarcoma 96 | 7,950
ovarian cancer 96 | 8,520
ependymoma 94 | 4,679
medulloblastoma, large-cell 94 | 6,241
psoriasis 86 | 6,694
atypical teratoid / rhabdoid tumor 84 | 5,112
adult high grade glioma 79 | 3,801
Kidney cancer 74 | 2,613
Astrocytoma, Pilocytic 73 | 3,081
primitive neuroectodermal tumor 68 | 3,035
oligodendroglioma 64 | 2,850
group 3 medulloblastoma 63 | 4,104
lung cancer 57 | 4,740
Breast cancer 56 | 3,578
astrocytic glioma 56 | 2,597
malignant mesothelioma 52 | 3,232
intraductal papillary-mucinous adenoma (IPMA) 48 | 2,955
subependymal giant cell astrocytoma 47 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 46 | 3,291
pancreatic cancer 45 | 2,398
lung carcinoma 42 | 2,843
non-small cell lung cancer 42 | 2,890
Pick disease 41 | 1,894
intraductal papillary-mucinous carcinoma (IPMC) 41 | 2,989
invasive ductal carcinoma 39 | 2,951
lung adenocarcinoma 37 | 2,716
ulcerative colitis 33 | 1,819
pituitary cancer 31 | 1,972
Cancer 30 | 2,499
acute quadriplegic myopathy 30 | 1,158
Autosomal recessive predisposition 29 | 1,442
Schizophrenia 29 | 1,160
colon cancer 29 | 1,478
group 4 medulloblastoma 29 | 1,855
Melanoma 28 | 711
cystic fibrosis 27 | 1,696
tuberculosis 25 | 2,010
Liver cancer 23 | 604
interstitial cystitis 23 | 2,312
Skin cancer 21 | 469
diabetes mellitus 21 | 1,728
Bipolar Disorder 20 | 666
primary pancreatic ductal adenocarcinoma 20 | 1,109
Duchenne muscular dystrophy 19 | 601
adrenocortical carcinoma 19 | 1,428
breast carcinoma 19 | 1,638
ductal carcinoma in situ 19 | 1,745
pediatric high grade glioma 19 | 1,064
Epilepsy 18 | 792
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,962
Seizures 17 | 596
Amyotrophic lateral sclerosis 16 | 451
astrocytoma 16 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 16 | 510
spina bifida 16 | 1,074
juvenile dermatomyositis 15 | 1,187
Endometrial cancer 14 | 311
Hypertension 14 | 396
Hypertensive disease 14 | 292
Rheumatoid arthritis 14 | 1,191
Depressive disorder 13 | 409
Intellectual disability 13 | 1,016
dermatomyositis 13 | 966
esophageal adenocarcinoma 13 | 737
Down syndrome 12 | 499
Hepatomegaly 12 | 285
Liver Cirrhosis, Experimental 12 | 769
Muscle hypotonia 12 | 571
Parkinson's disease 12 | 392
cutaneous lupus erythematosus 12 | 1,057
gastric carcinoma 12 | 807
interstitial lung disease 12 | 298
nasopharyngeal carcinoma 12 | 1,058
Atrial Fibrillation 11 | 124
Mental Depression 11 | 333
Multiple Sclerosis 11 | 540
Sensorineural hearing loss 11 | 106
medulloblastoma 11 | 720
Cognitive delay 10 | 608
Global developmental delay 10 | 608
Mental and motor retardation 10 | 608
Nonsyndromic deafness 10 | 142
Short stature 10 | 531
aldosterone-producing adenoma 10 | 665
Cardiac Arrhythmia 9 | 103
Cardiomyopathy 9 | 116
Cataract 9 | 297
Infantile onset 9 | 238
mucosa-associated lymphoid tissue lymphoma 9 | 484
non-small cell lung carcinoma 9 | 317
progressive supranuclear palsy 9 | 676
Atopic dermatitis 8 | 952
Dull intelligence 8 | 645
Low intelligence 8 | 645
Mental deficiency 8 | 645
Poor school performance 8 | 645
Prostatic Neoplasms 8 | 495
acute myeloid leukemia 8 | 783

Tissue

Endocrine System 194 | 18,159
Skin and soft tissues 188 | 17,230
Digestive Tract 187 | 17,369
Male tissues 184 | 17,142
Nervous System 184 | 16,725
Female tissues 180 | 17,400
Liver and Pancreas 180 | 16,750
Blood and immune system 177 | 16,909
Urinary Tract 176 | 16,678
Respiratory system 173 | 16,393
Cardiovascular System 167 | 15,192

Target Family

Non-IDG 92 | 12,091
Enzyme 35 | 4,145
Kinase 35 | 634
Ion Channel 23 | 344
Transporter 8 | 473
Transcription Factor 1 | 1,400

GO Function

calmodulin binding 194 | 194
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Neuromodulin GAP43 Tbio Non-IDG -2.93905 762.9 597
F-box/LRR-repeat protein 2 FBXL2 Tbio Non-IDG -0.89339 8.63 129
Unconventional myosin-XV MYO15A Tbio Non-IDG -1.64094 42.8 15
Probable ATP-dependent RNA helicase DDX5 DDX5 Tbio Enzyme -2.08566 121.1 344
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
Myosin-13 MYH13 Tbio Non-IDG -1.26079 16.6 12
Myosin-2 MYH2 Tbio Non-IDG -2.14128 114.9 63
Myristoylated alanine-rich C-kinase substrate MARCKS Tbio Enzyme -2.67762 525.7 663
Myosin-4 MYH4 Tbio Non-IDG -1.81214 51.8 52
Myosin-15 MYH15 Tbio Non-IDG -0.95780 9.01 40