Development Level

Tbio 466 | 11,651
Tdark 140 | 6,593
Tchem 64 | 1,388
Tclin 20 | 612

Collection

Ion Channel: IDG Consortium (T... 5 | 99
GPCR: IDG Consortium (Targets) 3 | 126
GPCR: IDG Consortium (Complete... 2 | 25
Kinase: IDG Consortium (Comple... 1 | 37
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, incomple... 31 | 499
preweaning lethality, complete... 26 | 979
abnormal behavior 13 | 298
decreased total body fat amoun... 12 | 207
decreased vertical activity 12 | 208
decreased bone mineral content 11 | 151
increased lean body mass 11 | 172
increased total body fat amoun... 10 | 134
decreased body weight 9 | 161
decreased prepulse inhibition 9 | 82
enlarged heart 9 | 210
abnormal heart morphology 8 | 162
decreased lean body mass 8 | 135
decreased startle reflex 8 | 75
embryonic lethality prior to t... 8 | 278
decreased bone mineral density 7 | 126
decreased circulating insulin ... 7 | 76
decreased fasted circulating g... 7 | 65
decreased grip strength 7 | 116
increased or absent threshold ... 7 | 101
short tibia 7 | 97
abnormal bone structure 6 | 187
abnormal gait 6 | 69
cardiovascular system phenotyp... 6 | 36
cataract 6 | 92
hyperactivity 6 | 148
impaired glucose tolerance 6 | 75
increased circulating HDL chol... 6 | 80
increased circulating alkaline... 6 | 122
abnormal coat-hair pigmentatio... 5 | 64
abnormal embryo size 5 | 220
abnormal eye morphology 5 | 68
abnormal lens morphology 5 | 81
abnormal seminal vesicle morph... 5 | 114
decreased circulating HDL chol... 5 | 68
decreased mean corpuscular vol... 5 | 79
hypoactivity 5 | 132
increased circulating choleste... 5 | 66
increased monocyte cell number 5 | 63
increased startle reflex 5 | 112
abnormal kidney morphology 4 | 65
abnormal retina morphology 4 | 71
abnormal sleep behavior 4 | 70
abnormal snout morphology 4 | 23
absent startle reflex 4 | 24
decreased body length 4 | 101
decreased circulating calcium ... 4 | 36
decreased circulating total pr... 4 | 49
decreased lymphocyte cell numb... 4 | 83
decreased mean corpuscular hem... 4 | 31
decreased neutrophil cell numb... 4 | 42
improved glucose tolerance 4 | 79
increased blood urea nitrogen ... 4 | 48
increased bone mineral content 4 | 108
increased circulating iron lev... 4 | 30
tremors 4 | 39
abnormal cranium morphology 3 | 36
abnormal locomotor behavior 3 | 24
abnormal tibia morphology 3 | 14
decreased circulating creatini... 3 | 39
decreased circulating iron lev... 3 | 32
decreased heart rate variabili... 3 | 13
decreased hemoglobin content 3 | 68
decreased mean platelet volume 3 | 25
edema 3 | 59
embryonic lethality prior to o... 3 | 239
enlarged spleen 3 | 41
female infertility 3 | 60
increased circulating chloride... 3 | 41
increased circulating sodium l... 3 | 71
increased circulating total pr... 3 | 28
increased fasted circulating g... 3 | 76
increased hematocrit 3 | 46
increased mean corpuscular hem... 3 | 96
increased mean platelet volume 3 | 45
limb grasping 3 | 41
male infertility 3 | 123
prolonged ST segment 3 | 36
small superior vagus ganglion 3 | 74
abnormal cornea morphology 2 | 31
abnormal head morphology 2 | 10
abnormal heart left ventricle ... 2 | 16
abnormal liver morphology 2 | 17
abnormal lung morphology 2 | 26
abnormal retinal vasculature m... 2 | 27
abnormal spleen morphology 2 | 55
abnormal vibrissa morphology 2 | 25
corneal opacity 2 | 32
decreased circulating amylase ... 2 | 28
decreased circulating serum al... 2 | 82
decreased circulating triglyce... 2 | 79
impaired pupillary reflex 2 | 26
increased body weight 2 | 25
increased bone mineral density 2 | 72
increased circulating phosphat... 2 | 26
increased heart weight 2 | 62
increased mean corpuscular vol... 2 | 92
increased prepulse inhibition 2 | 32
microphthalmia 2 | 26
vertebral fusion 2 | 23

Disease

Carcinoma 494 | 11,493
ovarian cancer 304 | 8,520
psoriasis 302 | 6,694
glioblastoma 283 | 5,792
osteosarcoma 260 | 7,950
medulloblastoma, large-cell 259 | 6,241
ependymoma 246 | 4,679
atypical teratoid / rhabdoid tumor 242 | 5,112
lung cancer 227 | 4,740
Kidney cancer 215 | 2,613
Breast cancer 211 | 3,578
lung carcinoma 191 | 2,843
Astrocytoma, Pilocytic 184 | 3,081
adult high grade glioma 184 | 3,801
group 3 medulloblastoma 183 | 4,104
oligodendroglioma 169 | 2,850
lung adenocarcinoma 161 | 2,716
intraductal papillary-mucinous neoplasm (IPMN) 160 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 159 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 155 | 2,989
pancreatic cancer 154 | 2,398
non-small cell lung cancer 153 | 2,890
primitive neuroectodermal tumor 150 | 3,035
invasive ductal carcinoma 146 | 2,951
astrocytic glioma 143 | 2,597
malignant mesothelioma 129 | 3,232
subependymal giant cell astrocytoma 121 | 2,287
pituitary cancer 116 | 1,972
interstitial cystitis 115 | 2,312
Cancer 105 | 2,499
group 4 medulloblastoma 95 | 1,855
Pick disease 94 | 1,894
cystic fibrosis 94 | 1,696
breast carcinoma 90 | 1,638
pancreatic ductal adenocarcinoma liver metastasis 89 | 1,962
ulcerative colitis 87 | 1,819
ductal carcinoma in situ 86 | 1,745
colon cancer 84 | 1,478
Autosomal recessive predisposition 80 | 1,442
Liver cancer 75 | 604
Melanoma 73 | 711
Schizophrenia 68 | 1,160
diabetes mellitus 68 | 1,728
primary pancreatic ductal adenocarcinoma 68 | 1,109
adrenocortical carcinoma 66 | 1,428
Skin cancer 62 | 469
Atopic dermatitis 61 | 952
tuberculosis 61 | 2,010
Duchenne muscular dystrophy 59 | 601
juvenile dermatomyositis 58 | 1,187
Liver Cirrhosis, Experimental 56 | 769
nasopharyngeal carcinoma 55 | 1,058
esophageal adenocarcinoma 54 | 737
Rheumatoid arthritis 53 | 1,191
astrocytoma 53 | 1,146
gastric carcinoma 53 | 807
pediatric high grade glioma 51 | 1,064
acute quadriplegic myopathy 50 | 1,158
cutaneous lupus erythematosus 50 | 1,057
active Crohn's disease 46 | 922
autosomal dominant Emery-Dreifuss muscular dystrophy 46 | 510
Bipolar Disorder 45 | 666
Endometrial cancer 43 | 311
Epilepsy 43 | 792
non primary Sjogren syndrome sicca 41 | 891
spina bifida 41 | 1,074
active ulcerative colitis 38 | 764
aldosterone-producing adenoma 38 | 665
fibroadenoma 38 | 559
Intellectual disability 37 | 1,016
dermatomyositis 37 | 966
Alzheimer's disease 33 | 658
Down syndrome 33 | 499
Prostatic Neoplasms 30 | 495
Kidney disease 29 | 430
mucosa-associated lymphoid tissue lymphoma 29 | 484
Seizures 28 | 596
primary Sjogren syndrome 27 | 735
Hypertension 26 | 396
Muscle hypotonia 26 | 571
Obesity 26 | 678
pancreatic carcinoma 26 | 562
Multiple myeloma 25 | 1,332
medulloblastoma 25 | 720
sonic hedgehog group medulloblastoma 25 | 467
Endometriosis 24 | 540
Short stature 24 | 531
Amyotrophic lateral sclerosis 23 | 451
Atherosclerosis 23 | 291
Becker muscular dystrophy 23 | 191
Osteoporosis 23 | 363
Vascular disease 23 | 319
Waldenstrons macroglobulinemia 23 | 765
atypical teratoid/rhabdoid tumor 23 | 357
chronic rhinosinusitis 23 | 512
limb girdle muscular dystrophy 2A 23 | 213
urothelial carcinoma 23 | 318
Global developmental delay 22 | 608
Low intelligence 22 | 645
Mental Retardation 22 | 645

Tissue

Endocrine System 667 | 18,159
Digestive Tract 656 | 17,369
Female tissues 649 | 17,400
Skin and soft tissues 645 | 17,230
Male tissues 638 | 17,142
Liver and Pancreas 634 | 16,750
Urinary Tract 627 | 16,678
Nervous System 626 | 16,725
Blood and immune system 619 | 16,909
Respiratory system 597 | 16,393
Cardiovascular System 546 | 15,192

Target Family

Non-IDG 512 | 12,091
Enzyme 121 | 4,145
Ion Channel 20 | 344
Transporter 15 | 473
GPCR 13 | 408
Kinase 7 | 634
Epigenetic 1 | 242
Transcription Factor 1 | 1,400

GO Function

calcium ion binding 690 | 690
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Calcium uptake protein 3, mitochondrial MICU3 Tdark Non-IDG -0.21085 1.14 50
Annexin A13 ANXA13 Tbio Non-IDG -1.19458 15.6 162
Filaggrin FLG Tbio Non-IDG -3.03594 1055.2 253
Thrombospondin-1 THBS1 Tbio Non-IDG -3.06622 1281.6 504
Desmoglein-3 DSG3 Tbio Non-IDG -2.57795 402.0 381
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 PLCB1 Tbio Enzyme -2.50444 332.8 190
Cysteine-rich with EGF-like domain protein 2 CRELD2 Tbio Non-IDG -0.79330 8.01 176
Protein S100-A7-like 2 S100A7L2 Tdark Non-IDG 0.30 0.14 25
Inactive serine protease PAMR1 PAMR1 Tdark Enzyme -0.86262 5.98 22
Collagen and calcium-binding EGF domain-containing protein 1 CCBE1 Tbio Non-IDG -1.27652 20.3 165