Development Level

Tbio 440 | 10,625
Tdark 154 | 7,003
Tchem 85 | 1,890
Tclin 16 | 602

Collection

Eligible Ion Channel Proteins 6 | 117
Eligible non-olfactory GPCR Proteins 6 | 143
Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 17 | 633
preweaning lethality, incomple... 15 | 260
abnormal behavior 14 | 226
decreased bone mineral content 11 | 157
decreased lean body mass 11 | 195
abnormal lens morphology 10 | 73
decreased body weight 10 | 174
decreased total body fat amoun... 9 | 186
abnormal retina morphology 7 | 100
decreased grip strength 7 | 123
decreased prepulse inhibition 7 | 52
embryonic lethality prior to t... 7 | 187
decreased body length 6 | 108
decreased bone mineral density 6 | 126
decreased circulating insulin ... 6 | 75
increased circulating alkaline... 6 | 119
increased or absent threshold ... 6 | 128
abnormal bone structure 5 | 131
abnormal retinal pigmentation 5 | 61
cardiovascular system phenotyp... 5 | 35
decreased circulating HDL chol... 5 | 77
decreased startle reflex 5 | 48
enlarged heart 5 | 111
hyperactivity 5 | 108
impaired glucose tolerance 5 | 52
increased circulating sodium l... 5 | 71
increased lean body mass 5 | 107
increased total body fat amoun... 5 | 57
abnormal coat/hair pigmentatio... 4 | 54
abnormal embryo size 4 | 112
abnormal eye morphology 4 | 38
decreased fasted circulating g... 4 | 49
decreased heart weight 4 | 44
decreased rib number 4 | 59
enlarged spleen 4 | 26
increased blood urea nitrogen ... 4 | 44
increased bone mineral content 4 | 92
increased circulating HDL chol... 4 | 63
increased grip strength 4 | 83
increased mean corpuscular hem... 4 | 93
increased rib number 4 | 41
short tibia 4 | 82
abnormal cranium morphology 3 | 32
abnormal digit morphology 3 | 13
abnormal gait 3 | 51
abnormal heart left ventricle ... 3 | 20
abnormal heart morphology 3 | 51
abnormal kidney morphology 3 | 30
abnormal optic disc morphology 3 | 10
abnormal retinal blood vessel ... 3 | 18
abnormal retinal vasculature m... 3 | 15
abnormal seminal vesicle morph... 3 | 47
abnormal sleep behavior 3 | 63
abnormal snout morphology 3 | 18
abnormal spleen morphology 3 | 36
abnormal tibia morphology 3 | 14
decreased circulating alanine ... 3 | 53
decreased circulating choleste... 3 | 85
decreased circulating free fat... 3 | 39
decreased circulating glucose ... 3 | 121
decreased circulating triglyce... 3 | 83
decreased hemoglobin content 3 | 53
female infertility 3 | 34
hypoactivity 3 | 89
improved glucose tolerance 3 | 56
increased body weight 3 | 42
increased circulating chloride... 3 | 43
increased circulating choleste... 3 | 53
increased hemoglobin content 3 | 45
increased mean corpuscular vol... 3 | 91
male infertility 3 | 62
straub tail 3 | 26
tremors 3 | 34
abnormal cornea morphology 2 | 24
abnormal eye size 2 | 11
abnormal liver morphology 2 | 5
abnormal locomotor activation 2 | 26
abnormal skin appearance 2 | 8
abnormal skin coloration 2 | 18
abnormal tooth morphology 2 | 24
abnormal vocalization 2 | 21
absent startle reflex 2 | 15
anophthalmia 2 | 20
corneal opacity 2 | 25
decreased circulating LDL chol... 2 | 37
decreased circulating creatini... 2 | 31
decreased circulating iron lev... 2 | 25
decreased eosinophil cell numb... 2 | 41
decreased heart rate variabili... 2 | 11
decreased mean corpuscular vol... 2 | 50
embryonic lethality prior to o... 2 | 148
hydrops fetalis 2 | 22
increased circulating iron lev... 2 | 25
increased erythrocyte cell num... 2 | 26
increased exploration in new e... 2 | 56
increased startle reflex 2 | 38
limb grasping 2 | 35
oligodactyly 2 | 14
small thymus 2 | 11
thrombocytopenia 2 | 46

Disease

psoriasis 307 | 6,685
ovarian cancer 300 | 8,484
glioblastoma 269 | 5,572
osteosarcoma 265 | 7,933
medulloblastoma, large-cell 256 | 6,234
atypical teratoid / rhabdoid tumor 207 | 4,369
lung cancer 197 | 4,466
lung carcinoma 192 | 2,844
Carcinoma 188 | 2,147
pilocytic astrocytoma 185 | 3,086
oligodendroglioma 166 | 2,849
lung adenocarcinoma 162 | 2,713
intraductal papillary-mucinous adenoma (IPMA) 159 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 159 | 3,289
Breast cancer 158 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 154 | 2,988
invasive ductal carcinoma 150 | 2,950
non-small cell lung cancer 150 | 2,798
primitive neuroectodermal tumor 147 | 3,031
pancreatic cancer 135 | 2,300
pediatric high grade glioma 134 | 2,712
malignant mesothelioma 130 | 3,162
interstitial cystitis 119 | 2,299
subependymal giant cell astrocytoma 119 | 2,287
ependymoma 118 | 2,514
pituitary cancer 116 | 1,972
astrocytic glioma 112 | 2,241
Cancer 106 | 2,346
ulcerative colitis 106 | 2,087
group 4 medulloblastoma 104 | 1,875
adult high grade glioma 102 | 2,148
cystic fibrosis 99 | 1,665
posterior fossa group A ependymoma 93 | 1,511
ductal carcinoma in situ 92 | 1,745
breast carcinoma 91 | 1,614
Pick disease 90 | 1,893
primary pancreatic ductal adenocarcinoma 85 | 1,271
colon cancer 83 | 1,475
astrocytoma 81 | 1,493
group 3 medulloblastoma 79 | 2,254
sonic hedgehog group medulloblastoma 77 | 1,482
pancreatic ductal adenocarcinoma liver metastasis 73 | 1,795
medulloblastoma 68 | 1,524
adrenocortical carcinoma 67 | 1,427
posterior fossa group B ependymoma 66 | 1,530
Atopic dermatitis 62 | 944
Duchenne muscular dystrophy 60 | 602
atypical teratoid/rhabdoid tumor 60 | 1,095
diabetes mellitus 60 | 1,663
juvenile dermatomyositis 58 | 1,189
nasopharyngeal carcinoma 57 | 1,056
gastric carcinoma 56 | 832
tuberculosis 55 | 1,557
esophageal adenocarcinoma 53 | 737
Rheumatoid Arthritis 51 | 1,160
cutaneous lupus erythematosus 51 | 1,056
acute quadriplegic myopathy 50 | 1,157
active Crohn's disease 46 | 918
autosomal dominant Emery-Dreifuss muscular dystrophy 45 | 499
spina bifida 41 | 1,064
fibroadenoma 40 | 557
aldosterone-producing adenoma 37 | 664
dermatomyositis 37 | 933
non primary Sjogren syndrome sicca 36 | 840
Down syndrome 32 | 548
primary Sjogren syndrome 32 | 789
Alzheimer's disease 31 | 644
mucosa-associated lymphoid tissue lymphoma 30 | 480
Schizophrenia 29 | 501
Prostatic Neoplasms 28 | 471
non-small cell lung carcinoma 28 | 413
Obesity 27 | 616
Kidney disease 26 | 396
Vascular disease 26 | 281
pancreatic carcinoma 26 | 567
Endometriosis 25 | 535
Multiple myeloma 25 | 1,327
Amyotrophic Lateral Sclerosis 24 | 431
Becker muscular dystrophy 23 | 187
Waldenstrons macroglobulinemia 23 | 765
active ulcerative colitis 23 | 477
acute myeloid leukemia 23 | 780
chronic rhinosinusitis 23 | 512
urothelial carcinoma 23 | 318
Atherosclerosis 22 | 275
limb girdle muscular dystrophy 2A 22 | 156
Kidney cancer 21 | 118
Mammary Neoplasms 21 | 410
Epilepsy 20 | 346
Intellectual disability 20 | 573
Autistic Disorder 19 | 320
Heart disease 19 | 279
glioblastoma multiforme 19 | 347
Asthma 18 | 349
periodontitis 18 | 269
progressive supranuclear palsy 18 | 674
Multiple Sclerosis 17 | 498
head and neck cancer 17 | 270
inflammatory breast cancer 17 | 404
nephrosclerosis 17 | 329

Tissue

Digestive Tract 682 | 18,473
Female tissues 681 | 18,647
Nervous System 679 | 18,561
Endocrine System 678 | 18,512
Urinary Tract 675 | 18,444
Liver and Pancreas 672 | 18,136
Blood and immune system 671 | 17,995
Cardiovascular System 671 | 17,958
Skin and soft tissues 667 | 18,115
Male tissues 666 | 17,969
Respiratory system 660 | 17,484

Target Family

Non-IDG 506 | 11,971
Enzyme 134 | 4,146
Ion Channel 19 | 341
Transporter 15 | 473
GPCR 12 | 406
Kinase 7 | 634
Epigenetic 1 | 242
Transcription Factor 1 | 1,400

GO Function

calcium ion binding 695 | 695
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
EGF-like repeat and discoidin I-like domain-containing protein 3 EDIL3 Tbio Non-IDG -1.83671 93.1 157
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Tolloid-like protein 1 TLL1 Tbio Non-IDG -1.40066 23.4 60
Transmembrane gamma-carboxyglutamic acid protein 3 PRRG3 Tdark Non-IDG -0.21639 1.71 76
Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B Tclin Ion Channel -2.21210 162.9 67
Transmembrane gamma-carboxyglutamic acid protein 4 PRRG4 Tdark Non-IDG -0.29670 2.24 21
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial PGS1 Tdark Enzyme -0.35218 2.20 100
Calumenin CALU Tbio Non-IDG -1.76431 61.4 157