Development Level

Tchem 26 | 1,598
Tbio 25 | 11,445
Tclin 10 | 613
Tdark 5 | 6,588

Collection

Ion Channel: IDG Consortium (T... 10 | 99

IMPC Phenotype

preweaning lethality, complete... 6 | 979
increased startle reflex 4 | 112
decreased fasted circulating g... 3 | 65
impaired glucose tolerance 3 | 75
preweaning lethality, incomple... 3 | 499
abnormal gait 2 | 69
decreased body weight 2 | 161
decreased prepulse inhibition 2 | 82
embryonic lethality prior to t... 2 | 278
hyperactivity 2 | 148
increased circulating chloride... 2 | 41
increased circulating sodium l... 2 | 71
increased lean body mass 2 | 172
increased total body fat amoun... 2 | 134
limb grasping 2 | 41
abnormal behavior 1 | 298
abnormal coat-hair pigmentatio... 1 | 64
abnormal epididymis morphology 1 | 42
abnormal forelimb morphology 1 | 2
abnormal iris transilluminatio... 1 | 2
abnormal lens morphology 1 | 81
abnormal limb morphology 1 | 13
abnormal locomotor activation 1 | 16
abnormal response to new envir... 1 | 10
abnormal retina morphology 1 | 71
abnormal tail morphology 1 | 25
corneal vascularization 1 | 6
cyanosis 1 | 7
decreased basophil cell number 1 | 16
decreased cardiac stroke volum... 1 | 6
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating free fat... 1 | 31
decreased circulating glucose ... 1 | 126
decreased circulating glycerol... 1 | 16
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
decreased neutrophil cell numb... 1 | 42
decreased vertical activity 1 | 208
edema 1 | 59
enlarged thymus 1 | 5
female infertility 1 | 60
hemorrhage 1 | 23
improved glucose tolerance 1 | 79
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased respiratory quotient 1 | 2
increased spleen weight 1 | 10
mammalian phenotype 1 | 17
prenatal lethality prior to he... 1 | 87
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
respiratory system phenotype 1 | 2

Disease

Carcinoma 57 | 11,493
Kidney cancer 31 | 2,613
glioblastoma 29 | 5,792
ovarian cancer 27 | 8,520
adult high grade glioma 26 | 3,801
atypical teratoid / rhabdoid tumor 26 | 5,112
medulloblastoma, large-cell 26 | 6,241
osteosarcoma 26 | 7,950
ependymoma 24 | 4,679
psoriasis 22 | 6,694
Astrocytoma, Pilocytic 17 | 3,081
primitive neuroectodermal tumor 16 | 3,035
lung cancer 15 | 4,740
lung carcinoma 15 | 2,843
group 3 medulloblastoma 14 | 4,104
oligodendroglioma 14 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
Bipolar Disorder 12 | 666
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
lung adenocarcinoma 12 | 2,716
Breast cancer 11 | 3,578
invasive ductal carcinoma 11 | 2,951
subependymal giant cell astrocytoma 11 | 2,287
Melanoma 10 | 711
Pick disease 10 | 1,894
astrocytic glioma 9 | 2,597
pituitary cancer 9 | 1,972
Epilepsy 8 | 792
Hypertension 8 | 396
Liver cancer 8 | 604
Schizophrenia 8 | 1,160
cutaneous lupus erythematosus 8 | 1,057
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
malignant mesothelioma 8 | 3,232
Cancer 7 | 2,499
Endometrial cancer 7 | 311
Skin cancer 7 | 469
pancreatic cancer 7 | 2,398
ulcerative colitis 7 | 1,819
Dentin sensitivity 6 | 14
Intellectual disability 6 | 1,016
Neuropathy 6 | 261
ductal carcinoma in situ 6 | 1,745
group 4 medulloblastoma 6 | 1,855
non-small cell lung cancer 6 | 2,890
tuberculosis 6 | 2,010
Autosomal dominant polycystic kidney disease 5 | 31
Migraine 5 | 83
Neurodegenerative disease 5 | 414
colon cancer 5 | 1,478
cystic fibrosis 5 | 1,696
diabetes mellitus 5 | 1,728
interstitial cystitis 5 | 2,312
medulloblastoma 5 | 720
Asthma 4 | 385
Kidney disease 4 | 430
Pain agnosia 4 | 104
Parkinson's disease 4 | 392
Rheumatoid arthritis 4 | 1,191
Syncope 4 | 22
adrenocortical carcinoma 4 | 1,428
aldosterone-producing adenoma 4 | 665
breast carcinoma 4 | 1,638
Adult onset 3 | 82
Alzheimer's disease 3 | 658
Atopic dermatitis 3 | 952
Autosomal recessive predisposition 3 | 1,442
Cerebellar Ataxia 3 | 304
Deglutition Disorders 3 | 132
Dysarthria 3 | 192
Dystonia 3 | 164
Endometriosis 3 | 540
Fever 3 | 138
Gangliosidosis 3 | 20
Hyperalgesia 3 | 83
Hypertensive disease 3 | 292
Local anesthesia 3 | 40
Nicotine dependence 3 | 54
Pain 3 | 103
Polycystic kidney disease 1 3 | 21
Progressive disorder 3 | 142
Vascular disease 3 | 319
astrocytoma 3 | 1,146
fibroadenoma 3 | 559
head and neck cancer 3 | 271
juvenile dermatomyositis 3 | 1,187
non primary Sjogren syndrome sicca 3 | 891
posterior fossa group B ependymoma 3 | 416
progressive supranuclear palsy 3 | 676
Amyotrophic lateral sclerosis 2 | 451
Atrophy of cerebellum 2 | 103
Cerebellar degeneration 2 | 103
Cerebral atrophy 2 | 178
Chromosome 15q13.3 microdeletion syndrome 2 | 11
Congenital stationary night blindness 2 | 29
Dementia 2 | 175
Dystonic disease 2 | 106
Infantile onset 2 | 238
Infratentorial atrophy 2 | 103
Tachycardia 2 | 43

Tissue

Endocrine System 63 | 18,159
Skin and soft tissues 61 | 17,230
Digestive Tract 59 | 17,369
Female tissues 59 | 17,400
Nervous System 59 | 16,725
Urinary Tract 59 | 16,678
Blood and immune system 58 | 16,909
Liver and Pancreas 58 | 16,750
Male tissues 57 | 17,142
Respiratory system 54 | 16,393
Cardiovascular System 48 | 15,192

Target Family

Ion Channel 50 | 344
Non-IDG 7 | 12,091
Transporter 5 | 473
Enzyme 3 | 4,145
Kinase 1 | 634

GO Function

calcium channel activity 66 | 66
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transient receptor potential cation channel subfamily V member 2 TRPV2 Tchem Ion Channel -2.28525 197.9 203
Pannexin-1 PANX1 Tbio Ion Channel -2.59888 418.5 154
Calcium-activated chloride channel regulator family member 3 CLCA3P Tdark Ion Channel 0.00000 0
Transient receptor potential cation channel subfamily M member 2 TRPM2 Tchem Ion Channel -1.34318 25.1 209
Transient receptor potential cation channel subfamily M member 7 TRPM7 Tchem Ion Channel -2.53154 365.5 317
Voltage-dependent calcium channel gamma-like subunit TMEM37 Tbio Ion Channel -2.84704 668.1 56
Short transient receptor potential channel 7 TRPC7 Tchem Ion Channel -2.43775 199.8 220
Transient receptor potential cation channel subfamily M member 3 TRPM3 Tchem Ion Channel -2.19236 141.8 121
Sodium/potassium/calcium exchanger 3 SLC24A3 Tbio Transporter -1.12274 13.0 86
Sodium/potassium/calcium exchanger 2 SLC24A2 Tbio Transporter -1.39605 25.7 32