Development Level

Tbio 230 | 10,625
Tchem 43 | 1,890
Tclin 4 | 602

Collection

Eligible Kinase Proteins 3 | 134
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 13 | 633
decreased lean body mass 8 | 195
preweaning lethality, incomple... 8 | 260
decreased total body fat amoun... 7 | 186
abnormal embryo size 6 | 112
decreased circulating HDL chol... 6 | 77
increased lean body mass 6 | 107
increased or absent threshold ... 6 | 128
decreased body weight 5 | 174
decreased circulating alanine ... 5 | 53
decreased bone mineral content 4 | 157
decreased circulating choleste... 4 | 85
decreased mean corpuscular vol... 4 | 50
improved glucose tolerance 4 | 56
abnormal sleep behavior 3 | 63
decreased circulating LDL chol... 3 | 37
decreased fasted circulating g... 3 | 49
decreased mean corpuscular hem... 3 | 34
embryonic lethality prior to t... 3 | 187
impaired glucose tolerance 3 | 52
increased bone mineral density 3 | 52
abnormal behavior 2 | 226
abnormal bone structure 2 | 131
abnormal craniofacial morpholo... 2 | 12
abnormal head morphology 2 | 10
abnormal neural tube closure 2 | 37
abnormal pericardium morpholog... 2 | 11
abnormal retina morphology 2 | 100
abnormal vertebrae morphology 2 | 14
decreased bone mineral density 2 | 126
decreased circulating alkaline... 2 | 41
decreased circulating chloride... 2 | 32
decreased circulating fructosa... 2 | 31
decreased circulating glucose ... 2 | 121
decreased circulating insulin ... 2 | 75
decreased circulating serum al... 2 | 79
decreased circulating total pr... 2 | 41
decreased circulating triglyce... 2 | 83
decreased lactate dehydrogenas... 2 | 14
decreased leukocyte cell numbe... 2 | 54
embryonic lethality prior to o... 2 | 148
enlarged heart 2 | 111
enlarged lymph nodes 2 | 27
increased body length 2 | 20
increased body weight 2 | 42
increased bone mineral content 2 | 92
increased circulating HDL chol... 2 | 63
increased circulating alkaline... 2 | 119
increased circulating chloride... 2 | 43
increased circulating phosphat... 2 | 24
increased fasted circulating g... 2 | 68
increased hematocrit 2 | 36
prenatal lethality prior to he... 2 | 64
short tibia 2 | 82
shortened RR interval 2 | 19
abnormal behavioral response t... 1 | 52
abnormal coping response 1 | 12
abnormal embryo turning 1 | 15
abnormal eye morphology 1 | 38
abnormal gait 1 | 51
abnormal lens morphology 1 | 73
abnormal retinal pigmentation 1 | 61
abnormal skin morphology 1 | 23
abnormal startle reflex 1 | 14
absent pinna reflex 1 | 21
absent teeth 1 | 4
craniofacial phenotype 1 | 9
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased circulating bilirubi... 1 | 14
decreased circulating calcium ... 1 | 33
decreased circulating iron lev... 1 | 25
decreased circulating potassiu... 1 | 17
decreased grip strength 1 | 123
decreased hemoglobin content 1 | 53
decreased lumbar vertebrae num... 1 | 62
decreased rib number 1 | 59
decreased threshold for audito... 1 | 32
decreased total retina thickne... 1 | 20
embryonic growth retardation 1 | 28
enlarged spleen 1 | 26
female infertility 1 | 34
hemorrhage 1 | 12
hydrops fetalis 1 | 22
increased circulating amylase ... 1 | 13
increased circulating calcium ... 1 | 32
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating glucose ... 1 | 16
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 26
increased grip strength 1 | 83
increased heart weight 1 | 37
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 25
increased total body fat amoun... 1 | 57
pallor 1 | 13
prenatal lethality 1 | 16
shortened ST segment 1 | 9
tremors 1 | 34

Disease

ovarian cancer 187 | 8,484
osteosarcoma 145 | 7,933
psoriasis 127 | 6,685
glioblastoma 125 | 5,572
medulloblastoma, large-cell 116 | 6,234
lung cancer 105 | 4,466
atypical teratoid / rhabdoid tumor 98 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 82 | 3,289
pancreatic cancer 80 | 2,300
Cancer 73 | 2,346
intraductal papillary-mucinous carcinoma (IPMC) 70 | 2,988
Breast cancer 69 | 3,094
lung adenocarcinoma 68 | 2,713
pediatric high grade glioma 64 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 63 | 2,956
Multiple myeloma 62 | 1,327
ependymoma 61 | 2,514
invasive ductal carcinoma 60 | 2,950
non-small cell lung cancer 57 | 2,798
oligodendroglioma 57 | 2,849
Carcinoma 56 | 2,147
pilocytic astrocytoma 54 | 3,086
malignant mesothelioma 51 | 3,162
primary pancreatic ductal adenocarcinoma 51 | 1,271
subependymal giant cell astrocytoma 51 | 2,287
astrocytoma 50 | 1,493
pancreatic ductal adenocarcinoma liver metastasis 50 | 1,795
primitive neuroectodermal tumor 50 | 3,031
spina bifida 49 | 1,064
dermatomyositis 48 | 933
Waldenstrons macroglobulinemia 47 | 765
group 4 medulloblastoma 44 | 1,875
astrocytic glioma 43 | 2,241
acute quadriplegic myopathy 41 | 1,157
diabetes mellitus 41 | 1,663
lung carcinoma 37 | 2,844
interstitial cystitis 36 | 2,299
Pick disease 35 | 1,893
juvenile dermatomyositis 35 | 1,189
breast carcinoma 34 | 1,614
Rheumatoid Arthritis 33 | 1,160
tuberculosis 33 | 1,557
ductal carcinoma in situ 32 | 1,745
sonic hedgehog group medulloblastoma 32 | 1,482
adult high grade glioma 29 | 2,148
medulloblastoma 29 | 1,524
pituitary cancer 29 | 1,972
esophageal adenocarcinoma 28 | 737
ulcerative colitis 28 | 2,087
posterior fossa group A ependymoma 27 | 1,511
colon cancer 26 | 1,475
cystic fibrosis 24 | 1,665
Down syndrome 22 | 548
adrenocortical carcinoma 22 | 1,427
group 3 medulloblastoma 22 | 2,254
nasopharyngeal carcinoma 22 | 1,056
gastric carcinoma 20 | 832
Alzheimer's disease 19 | 644
Amyotrophic Lateral Sclerosis 19 | 431
Duchenne muscular dystrophy 19 | 602
acute myeloid leukemia 19 | 780
autosomal dominant Emery-Dreifuss muscular dystrophy 18 | 499
tuberculosis and treatment for 6 months 17 | 686
Mammary Neoplasms 16 | 410
Osteoporosis 16 | 257
cutaneous lupus erythematosus 16 | 1,056
progressive supranuclear palsy 16 | 674
Neurodegenerative disease 15 | 383
hereditary spastic paraplegia 15 | 313
posterior fossa group B ependymoma 15 | 1,530
Liver carcinoma 14 | 217
Prostatic Neoplasms 14 | 471
atypical teratoid/rhabdoid tumor 14 | 1,095
Animal Mammary Neoplasms 13 | 136
Intellectual disability 13 | 573
Neoplasm Invasiveness 13 | 127
active Crohn's disease 13 | 918
aldosterone-producing adenoma 13 | 664
non primary Sjogren syndrome sicca 13 | 840
Mammary Neoplasms, Experimental 12 | 150
active ulcerative colitis 12 | 477
gastric cancer 12 | 430
pancreatic carcinoma 12 | 567
Atopic dermatitis 11 | 944
IGA Glomerulonephritis 11 | 454
Schizophrenia 11 | 501
mucosa-associated lymphoid tissue lymphoma 11 | 480
primary Sjogren syndrome 11 | 789
Neoplasm Metastasis 10 | 138
Obesity 10 | 616
Parkinson's disease 10 | 364
Stomach Neoplasms 10 | 282
non-small cell lung carcinoma 10 | 413
Disease Progression 9 | 125
Renal Cell Carcinoma 9 | 199
Squamous cell carcinoma 9 | 94
Squamous cell carcinoma of esophagus 9 | 82
Vascular disease 9 | 281
hepatocellular carcinoma 9 | 532
Becker muscular dystrophy 8 | 187

Tissue

Blood and immune system 277 | 17,995
Cardiovascular System 277 | 17,958
Digestive Tract 277 | 18,473
Endocrine System 277 | 18,512
Female tissues 277 | 18,647
Liver and Pancreas 277 | 18,136
Male tissues 277 | 17,969
Nervous System 277 | 18,561
Respiratory system 277 | 17,484
Skin and soft tissues 277 | 18,115
Urinary Tract 277 | 18,444

Target Family

Non-IDG 214 | 11,971
Enzyme 40 | 4,146
Kinase 16 | 634
Transporter 3 | 473
Epigenetic 1 | 242
GPCR 1 | 406
Ion Channel 1 | 341
Transcription Factor 1 | 1,400

GO Function

cadherin binding involved in c... 277 | 277
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Charged multivesicular body protein 2b CHMP2B Tbio Non-IDG -1.65708 53.0 166
F-actin-capping protein subunit alpha-1 CAPZA1 Tbio Non-IDG -1.28182 20.1 139
Host cell factor 1 HCFC1 Tbio Non-IDG -2.50024 341.6 160
Fatty acid synthase FASN Tchem Enzyme -2.49948 348.5 388
Pyruvate kinase PKM PKM Tchem Kinase -3.09101 1313.5 672
Emerin EMD Tbio Non-IDG -2.77469 617.6 238
Neuroblast differentiation-associated protein AHNAK AHNAK Tbio Non-IDG -1.61845 51.3 82
60S ribosomal protein L7a RPL7A Tbio Non-IDG -1.66015 45.9 60
Golgin subfamily A member 2 GOLGA2 Tbio Non-IDG -1.94177 80.5 168
Golgin subfamily A member 3 GOLGA3 Tbio Non-IDG -1.29668 20.3 130