Development Level

Tbio 225 | 11,445
Tchem 35 | 1,598
Tdark 13 | 6,588
Tclin 4 | 613

Collection

Kinase: IDG Consortium (Target... 3 | 125
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 25 | 979
preweaning lethality, incomple... 15 | 499
abnormal embryo size 8 | 220
decreased total body fat amoun... 6 | 207
embryonic lethality prior to o... 6 | 239
embryonic lethality prior to t... 6 | 278
increased lean body mass 6 | 172
abnormal behavior 5 | 298
decreased body weight 5 | 161
decreased circulating HDL chol... 5 | 68
decreased lean body mass 5 | 135
decreased mean corpuscular vol... 5 | 79
abnormal bone structure 4 | 187
abnormal craniofacial morpholo... 4 | 33
abnormal neural tube closure 4 | 46
decreased bone mineral content 4 | 151
decreased circulating alanine ... 4 | 47
decreased circulating choleste... 4 | 93
increased circulating phosphat... 4 | 26
abnormal embryo turning 3 | 31
abnormal gait 3 | 69
abnormal skin morphology 3 | 50
decreased caudal vertebrae num... 3 | 53
decreased circulating LDL chol... 3 | 38
decreased circulating alkaline... 3 | 46
decreased circulating serum al... 3 | 82
decreased fasted circulating g... 3 | 65
decreased leukocyte cell numbe... 3 | 73
decreased vertical activity 3 | 208
edema 3 | 59
embryonic growth retardation 3 | 106
enlarged heart 3 | 210
enlarged lymph nodes 3 | 37
hyperactivity 3 | 148
improved glucose tolerance 3 | 79
increased circulating alkaline... 3 | 122
increased or absent threshold ... 3 | 101
increased startle reflex 3 | 112
increased total body fat amoun... 3 | 134
prenatal lethality prior to he... 3 | 87
short tibia 3 | 97
tremors 3 | 39
abnormal behavioral response t... 2 | 66
abnormal eye morphology 2 | 68
abnormal forebrain morphology 2 | 10
abnormal hindbrain morphology 2 | 10
abnormal midbrain morphology 2 | 10
abnormal pericardium morpholog... 2 | 26
abnormal placenta size 2 | 20
abnormal retina morphology 2 | 71
abnormal sleep behavior 2 | 70
abnormal tail morphology 2 | 25
abnormal vertebrae morphology 2 | 18
cyanosis 2 | 7
decreased basophil cell number 2 | 16
decreased blood urea nitrogen ... 2 | 51
decreased bone mineral density 2 | 126
decreased circulating amylase ... 2 | 28
decreased circulating total pr... 2 | 49
decreased circulating triglyce... 2 | 79
decreased lactate dehydrogenas... 2 | 16
decreased mean corpuscular hem... 2 | 50
hemorrhage 2 | 23
hypoactivity 2 | 132
impaired glucose tolerance 2 | 75
increased body temperature 2 | 9
increased body weight 2 | 25
increased bone mineral content 2 | 108
increased circulating HDL chol... 2 | 80
increased circulating chloride... 2 | 41
increased heart weight 2 | 62
increased monocyte cell number 2 | 63
pallor 2 | 34
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
shortened RR interval 2 | 17
abnormal cornea morphology 1 | 31
abnormal head morphology 1 | 10
abnormal retinal inner nuclear... 1 | 8
abnormal whole-body plethysmog... 1 | 4
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating iron lev... 1 | 32
decreased circulating potassiu... 1 | 20
decreased eosinophil cell numb... 1 | 24
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased pulmonary respirator... 1 | 5
decreased red blood cell distr... 1 | 41
decreased total retina thickne... 1 | 17
enlarged spleen 1 | 41
increased body length 1 | 32
increased bone mineral density 1 | 72
increased circulating amylase ... 1 | 25
increased circulating choleste... 1 | 66
increased circulating iron lev... 1 | 30
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
thin ventricular wall 1 | 24
thrombocytosis 1 | 27

Disease

Carcinoma 202 | 11,493
ovarian cancer 183 | 8,520
osteosarcoma 148 | 7,950
glioblastoma 125 | 5,792
psoriasis 122 | 6,694
medulloblastoma, large-cell 112 | 6,241
lung cancer 108 | 4,740
atypical teratoid / rhabdoid tumor 104 | 5,112
ependymoma 93 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 79 | 3,291
Breast cancer 78 | 3,578
Cancer 78 | 2,499
pancreatic cancer 75 | 2,398
Kidney cancer 70 | 2,613
lung adenocarcinoma 69 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 68 | 2,989
Multiple myeloma 63 | 1,332
adult high grade glioma 63 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 62 | 2,955
invasive ductal carcinoma 60 | 2,951
malignant mesothelioma 57 | 3,232
non-small cell lung cancer 57 | 2,890
oligodendroglioma 57 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 56 | 1,962
group 3 medulloblastoma 54 | 4,104
Astrocytoma, Pilocytic 50 | 3,081
primitive neuroectodermal tumor 50 | 3,035
subependymal giant cell astrocytoma 50 | 2,287
astrocytic glioma 49 | 2,597
dermatomyositis 48 | 966
Waldenstrons macroglobulinemia 46 | 765
spina bifida 43 | 1,074
astrocytoma 42 | 1,146
group 4 medulloblastoma 42 | 1,855
tuberculosis 41 | 2,010
diabetes mellitus 39 | 1,728
acute quadriplegic myopathy 38 | 1,158
Pick disease 36 | 1,894
breast carcinoma 35 | 1,638
interstitial cystitis 34 | 2,312
primary pancreatic ductal adenocarcinoma 34 | 1,109
lung carcinoma 33 | 2,843
Rheumatoid arthritis 32 | 1,191
juvenile dermatomyositis 32 | 1,187
ductal carcinoma in situ 31 | 1,745
colon cancer 30 | 1,478
Schizophrenia 29 | 1,160
pediatric high grade glioma 27 | 1,064
ulcerative colitis 27 | 1,819
esophageal adenocarcinoma 26 | 737
pituitary cancer 26 | 1,972
cystic fibrosis 24 | 1,696
Liver Cirrhosis, Experimental 23 | 769
adrenocortical carcinoma 23 | 1,428
Autosomal recessive predisposition 21 | 1,442
gastric carcinoma 21 | 807
nasopharyngeal carcinoma 21 | 1,058
acute myeloid leukemia 20 | 783
Alzheimer's disease 19 | 658
Amyotrophic lateral sclerosis 19 | 451
Down syndrome 19 | 499
progressive supranuclear palsy 18 | 676
Carcinoma, Hepatocellular 17 | 228
Osteoporosis 17 | 363
medulloblastoma 17 | 720
Breast Neoplasms 16 | 445
Intellectual disability 16 | 1,016
Liver carcinoma 16 | 240
Neurodegenerative disease 16 | 414
active ulcerative colitis 16 | 764
cutaneous lupus erythematosus 16 | 1,057
non primary Sjogren syndrome sicca 16 | 891
Bipolar Disorder 15 | 666
Duchenne muscular dystrophy 15 | 601
Liver cancer 15 | 604
Mammary Neoplasms 15 | 425
autosomal dominant Emery-Dreifuss muscular dystrophy 15 | 510
hereditary spastic paraplegia 15 | 318
sonic hedgehog group medulloblastoma 15 | 467
Neoplasm Invasiveness 14 | 161
Melanoma 13 | 711
Neoplasm Metastasis 13 | 168
gastric cancer 13 | 459
pancreatic carcinoma 13 | 562
Stomach Neoplasms 12 | 300
active Crohn's disease 12 | 922
primary Sjogren syndrome 12 | 735
Adenocarcinoma of lung 11 | 142
Lung Neoplasms 11 | 232
Obesity 11 | 678
Parkinson's disease 11 | 392
Prostatic Neoplasms 11 | 495
Renal Cell Carcinoma 11 | 214
Short stature 11 | 531
Vascular disease 11 | 319
aldosterone-producing adenoma 11 | 665
mucosa-associated lymphoid tissue lymphoma 11 | 484
sarcoidosis 11 | 370
tuberculosis and treatment for 6 months 11 | 409
Muscle hypotonia 10 | 571

Tissue

Blood and immune system 276 | 16,909
Digestive Tract 276 | 17,369
Endocrine System 276 | 18,159
Female tissues 276 | 17,400
Liver and Pancreas 276 | 16,750
Male tissues 276 | 17,142
Respiratory system 276 | 16,393
Skin and soft tissues 276 | 17,230
Urinary Tract 276 | 16,678
Nervous System 275 | 16,725
Cardiovascular System 274 | 15,192

Target Family

Non-IDG 208 | 12,091
Enzyme 44 | 4,145
Kinase 15 | 634
Ion Channel 4 | 344
Transporter 3 | 473
Epigenetic 1 | 242
GPCR 1 | 408
Transcription Factor 1 | 1,400

GO Function

cadherin binding 277 | 277
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sorting nexin-5 SNX5 Tbio Non-IDG -1.23706 20.8 141
Junctional adhesion molecule A F11R Tbio Non-IDG -2.56739 380.0 394
Matrix metalloproteinase-24 MMP24 Tbio Enzyme -1.38282 25.8 147
Arginine and glutamate-rich protein 1 ARGLU1 Tdark Non-IDG -0.29373 1.70 72
Serine/threonine-protein kinase 24 STK24 Tchem Kinase -2.24110 132.9 243
Staphylococcal nuclease domain-containing protein 1 SND1 Tbio Epigenetic -2.35812 225.9 175
CD2-associated protein CD2AP Tbio Non-IDG -3.44533 2735.9 82
Endophilin-A2 SH3GL1 Tbio Non-IDG -2.15479 134.2 257
Plakophilin-2 PKP2 Tbio Non-IDG -2.10355 135.3 243
Vigilin HDLBP Tbio Non-IDG -2.01228 106.9 233