Development Level

Tbio 5 | 11,445
Tchem 2 | 1,598

IMPC Phenotype

abnormal coat- hair morphology 1 | 19
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
embryonic lethality prior to o... 1 | 239
increased aggression 1 | 4
increased grip strength 1 | 41
increased total body fat amoun... 1 | 134
preweaning lethality, complete... 1 | 979

Disease

ovarian cancer 6 | 8,520
Autosomal recessive predisposition 5 | 1,442
lung cancer 5 | 4,740
osteosarcoma 5 | 7,950
Breast cancer 4 | 3,578
Carcinoma 4 | 11,493
Cataract 4 | 297
Cryptorchidism 4 | 296
Hypogonadism 4 | 173
Lens Opacities 4 | 231
Photosensitivity of skin 4 | 51
Short stature 4 | 531
lung adenocarcinoma 4 | 2,716
medulloblastoma, large-cell 4 | 6,241
Atrophic condition of skin 3 | 25
Basal cell carcinoma 3 | 54
Basal cell nevi 3 | 23
Cancer 3 | 2,499
Cockayne syndrome 3 | 60
Erythema 3 | 58
Fetal Growth Retardation 3 | 189
Fever 3 | 138
Flushing 3 | 60
Hyperkeratosis 3 | 50
Infant, Small for Gestational Age 3 | 176
Intrauterine retardation 3 | 176
Kidney cancer 3 | 2,613
Optic Atrophy 3 | 242
Poikiloderma 3 | 14
Rothmund-Thomson syndrome 3 | 19
Strabismus 3 | 270
Telangiectasia of the skin 3 | 39
Xeroderma pigmentosum 3 | 43
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
invasive ductal carcinoma 3 | 2,951
psoriasis 3 | 6,694
Abnormally small eyeball 2 | 97
Arthralgia 2 | 90
Congenital clubfoot 2 | 109
Congenital deafness 2 | 185
Conjunctival telangiectasis 2 | 14
Deafness 2 | 198
Decreased size of eyeball 2 | 97
Dental abnormalities 2 | 60
Developmental regression 2 | 95
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diarrhea 2 | 253
Dry skin 2 | 75
Dull intelligence 2 | 645
Electroencephalogram abnormal 2 | 101
Epilepsy 2 | 792
Failure to gain weight 2 | 365
Fanconi anemia 2 | 56
Fatigue 2 | 182
Freckles 2 | 33
Hearing Loss, Partial 2 | 185
Hyperpigmented macules 2 | 42
Hypoplastic mandible condyle 2 | 275
Impaired cognition 2 | 96
Keratitis 2 | 62
Loss of developmental milestones 2 | 95
Malignant Squamous Cell Neoplasm 2 | 17
Melanoma 2 | 711
Mental deficiency 2 | 645
Mental deterioration in childhood 2 | 95
Mental impairment 2 | 95
Myocardial Infarction 2 | 151
Narrow face 2 | 54
Neurodevelopmental regression 2 | 95
Osteoporosis 2 | 363
Papilloma 2 | 44
Pediatric failure to thrive 2 | 365
Poor school performance 2 | 645
Progressive mental retardation 2 | 37
Psychomotor regression 2 | 95
Psychomotor regression beginning in infancy 2 | 95
Psychomotor regression in infants 2 | 95
Psychomotor regression, progressive 2 | 95
Seizures 2 | 596
Sensorineural Hearing Loss (disorder) 2 | 284
Short nose 2 | 132
Small head 2 | 374
Small nose 2 | 132
Spider Veins 2 | 17
Squamous cell carcinoma 2 | 129
Telangiectasis 2 | 36
Thin face 2 | 54
Thin skin 2 | 47
Tooth Abnormalities 2 | 69
Vertical Talus 2 | 25
Xerosis 2 | 75
adult high grade glioma 2 | 3,801
colon cancer 2 | 1,478
diabetes mellitus 2 | 1,728
glioblastoma 2 | 5,792
group 3 medulloblastoma 2 | 4,104
hearing impairment 2 | 199
hypopigmented skin patch 2 | 59
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
non-small cell lung cancer 2 | 2,890

Tissue

Blood and immune system 6 | 16,909
Digestive Tract 6 | 17,369
Endocrine System 6 | 18,159
Female tissues 6 | 17,400
Liver and Pancreas 6 | 16,750
Male tissues 6 | 17,142
Nervous System 6 | 16,725
Respiratory system 6 | 16,393
Skin and soft tissues 6 | 17,230
Urinary Tract 6 | 16,678
Cardiovascular System 5 | 15,192

Target Family

Enzyme 4 | 4,145
Non-IDG 2 | 12,091
Transcription Factor 1 | 1,400

GO Function

bubble DNA binding 7 | 7
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
ATP-dependent DNA helicase Q4 RECQL4 Tbio Enzyme 0.00000 0
DNA repair protein complementing XP-G cells ERCC5 Tchem Enzyme -2.06679 113.9 255
Endonuclease 8-like 3 NEIL3 Tbio Enzyme -1.53902 37.4 137
DNA repair protein complementing XP-C cells XPC Tbio Non-IDG -2.21142 154.0 208
High mobility group protein B1 HMGB1 Tbio Transcription Factor -3.05199 2190.4 1145
Werner syndrome ATP-dependent helicase WRN Tbio Enzyme -2.73759 569.7 210
Bloom syndrome protein BLM Tchem Non-IDG -2.03028 104.1 314