Development Level

Tbio 29 | 11,445
Tchem 1 | 1,598

Disease

Carcinoma 27 | 11,493
tuberculosis 27 | 2,010
Cancer 26 | 2,499
diabetes mellitus 25 | 1,728
Hypersensitivity reaction type II disease 23 | 253
Anemia 22 | 365
Hemochromatosis 22 | 54
Kidney disease 22 | 430
Leprosy 22 | 73
Liver disease 22 | 237
Multiple Sclerosis 22 | 540
Acquired immunodeficiency syndrome 21 | 197
Ankylosing spondylitis 21 | 140
Arthritis 21 | 290
Behcet's disease 21 | 89
Birdshot chorioretinopathy 21 | 23
Hepatitis B 21 | 108
Herpes zoster 21 | 68
Juvenile rheumatoid arthritis 21 | 111
Primary immunodeficiency disease 21 | 54
Skin disease 21 | 66
Uveitis 21 | 103
ovarian cancer 5 | 8,520
Astrocytoma, Pilocytic 4 | 3,081
cutaneous lupus erythematosus 4 | 1,057
lung cancer 4 | 4,740
osteosarcoma 4 | 7,950
psoriasis 4 | 6,694
Langerhans-cell histiocytosis 3 | 12
Schizophrenia 3 | 1,160
active Crohn's disease 3 | 922
adult high grade glioma 3 | 3,801
astrocytoma 3 | 1,146
glioblastoma 3 | 5,792
lung carcinoma 3 | 2,843
malignant mesothelioma 3 | 3,232
medulloblastoma, large-cell 3 | 6,241
non-small cell lung cancer 3 | 2,890
subependymal giant cell astrocytoma 3 | 2,287
Coronary artery disease 2 | 268
Duchenne muscular dystrophy 2 | 601
Melanoma 2 | 711
Multiple myeloma 2 | 1,332
Parapsoriasis 2 | 6
Skin cancer 2 | 469
atypical teratoid / rhabdoid tumor 2 | 5,112
dermatomyositis 2 | 966
ductal carcinoma in situ 2 | 1,745
ependymoma 2 | 4,679
juvenile dermatomyositis 2 | 1,187
lung adenocarcinoma 2 | 2,716
nasopharyngeal carcinoma 2 | 1,058
primary Sjogren syndrome 2 | 735
Abnormal vision 1 | 52
Abnormality of the hypothalamus-pituitary axis 1 | 12
Arthralgia 1 | 90
Arthropathy 1 | 43
Ascites 1 | 22
Atrophy of testis 1 | 14
Autism Spectrum Disorders 1 | 75
Autoimmune neuropathy 1 | 6
Azoospermia 1 | 110
Calcium pyrophosphate deposition disease 1 | 13
Cardiomegaly 1 | 116
Erectile dysfunction 1 | 32
Fatigue 1 | 182
Fatty liver disease 1 | 103
Glioma 1 | 74
Guillain-Barre syndrome 1 | 14
Gynecomastia 1 | 64
Hemolytic anemia 1 | 77
Hepatitis 1 | 67
Hepatitis C 1 | 94
Hyperpigmentation 1 | 37
Hypogonadism, Isolated Hypogonadotropic 1 | 71
Hypogonadotropic hypogonadism 1 | 89
Increased hepatocellular carcinoma risk 1 | 27
Increased incidence of hepatocellular carcinoma 1 | 27
Iron deficiency anemia 1 | 12
Iron metabolism disease 1 | 20
Juvenile xanthogranuloma 1 | 7
MYELODYSPLASTIC SYNDROME 1 | 53
Macular holes 1 | 11
Myelodysplastic Syndromes 1 | 26
Nonorganic psychosis 1 | 84
Pallor of optic disc 1 | 39
Paranoia 1 | 20
Photodysphoria 1 | 121
Photophobia 1 | 121
Polyneuropathy 1 | 64
Spider Veins 1 | 17
Steatohepatitis 1 | 44
Stevens-Johnson syndrome 1 | 92
Telangiectasis 1 | 36
Thalassemia 1 | 53
Typhoid fever 1 | 22
X-linked sideroblastic anemia 1 | 4
inflammatory breast cancer 1 | 286
interstitial lung disease 1 | 298
non-small cell lung cancer and chronic obstructive pulmonary disease 1 | 8

Tissue

Blood and immune system 8 | 16,909
Digestive Tract 8 | 17,369
Endocrine System 8 | 18,159
Female tissues 8 | 17,400
Liver and Pancreas 8 | 16,750
Male tissues 8 | 17,142
Respiratory system 8 | 16,393
Skin and soft tissues 8 | 17,230
Urinary Tract 8 | 16,678
Cardiovascular System 7 | 15,192
Nervous System 6 | 16,725

Target Family

Non-IDG 30 | 12,091

GO Function

beta-2-microglobulin binding 30 | 30
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

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