Development Level

Tbio 23 | 11,445
Tchem 2 | 1,598

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

increased bone mineral density 2 | 72
preweaning lethality, incomple... 2 | 499
abnormal bone structure 1 | 187
abnormal heart left ventricle ... 1 | 16
abnormal kidney morphology 1 | 65
abnormal retina morphology 1 | 71
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating insulin ... 1 | 76
decreased fasted circulating g... 1 | 65
decreased heart left ventricle... 1 | 28
decreased total body fat amoun... 1 | 207
embryonic lethality prior to t... 1 | 278
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased fasted circulating g... 1 | 76
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
prenatal lethality prior to he... 1 | 87
thin ventricular wall 1 | 24

Disease

ovarian cancer 17 | 8,520
Cancer 15 | 2,499
osteosarcoma 15 | 7,950
glioblastoma 14 | 5,792
Carcinoma 13 | 11,493
medulloblastoma, large-cell 13 | 6,241
psoriasis 12 | 6,694
lung cancer 11 | 4,740
primitive neuroectodermal tumor 10 | 3,035
atypical teratoid / rhabdoid tumor 9 | 5,112
group 3 medulloblastoma 9 | 4,104
ependymoma 8 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
invasive ductal carcinoma 7 | 2,951
malignant mesothelioma 7 | 3,232
non-small cell lung cancer 7 | 2,890
Astrocytoma, Pilocytic 6 | 3,081
Bipolar Disorder 6 | 666
Breast cancer 6 | 3,578
diabetes mellitus 6 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
lung adenocarcinoma 6 | 2,716
oligodendroglioma 6 | 2,850
pancreatic cancer 6 | 2,398
pituitary cancer 6 | 1,972
Congenital heart disease 5 | 93
Schizophrenia 5 | 1,160
adult high grade glioma 5 | 3,801
astrocytic glioma 5 | 2,597
ductal carcinoma in situ 5 | 1,745
subependymal giant cell astrocytoma 5 | 2,287
tuberculosis 5 | 2,010
Chronic Lymphocytic Leukemia 4 | 262
Congenital deafness 4 | 185
Craniofacial Abnormalities 4 | 151
Deafness 4 | 198
Hearing Loss, Partial 4 | 185
Heart disease 4 | 306
Orbital separation excessive 4 | 244
Parkinson's disease 4 | 392
Strabismus 4 | 270
adrenocortical carcinoma 4 | 1,428
breast carcinoma 4 | 1,638
cystic fibrosis 4 | 1,696
group 4 medulloblastoma 4 | 1,855
hearing impairment 4 | 199
interstitial cystitis 4 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
pediatric high grade glioma 4 | 1,064
primary pancreatic ductal adenocarcinoma 4 | 1,109
ulcerative colitis 4 | 1,819
Acquired scoliosis 3 | 281
Cleft Palate 3 | 271
Concave bridge of nose 3 | 195
Congenital hypoplasia of penis 3 | 176
Corneal disease 3 | 31
Coronary artery disease 3 | 268
Craniosynostosis 3 | 74
Curvature of spine 3 | 282
Depressed nasal bridge 3 | 195
Depressed nasal root/bridge 3 | 195
Exophthalmos 3 | 112
Failure to gain weight 3 | 365
Frontal bossing 3 | 157
Kidney cancer 3 | 2,613
Kidney disease 3 | 430
Liver Cirrhosis, Experimental 3 | 769
Low set ears 3 | 181
Muscle hypotonia 3 | 571
Neoplasm Metastasis 3 | 168
Osteoarthritis 3 | 184
Pediatric failure to thrive 3 | 365
Pick disease 3 | 1,894
Prominent eyes 3 | 96
Prominent globes 3 | 96
Protruding eyes 3 | 96
Short stature 3 | 531
Uranostaphyloschisis 3 | 167
Waldenstrons macroglobulinemia 3 | 765
X-linked cerebral adrenoleukodystrophy 3 | 116
acute quadriplegic myopathy 3 | 1,158
aldosterone-producing adenoma 3 | 665
atypical teratoid/rhabdoid tumor 3 | 357
colon cancer 3 | 1,478
gastric carcinoma 3 | 807
head and neck cancer 3 | 271
lung carcinoma 3 | 2,843
nephrosclerosis 3 | 333
Acrocephalosyndactylia 2 | 17
Brain infarction 2 | 22
Gastroesophageal reflux disease 2 | 110
Heartburn 2 | 78
Hernia, Inguinal 2 | 89
Intracranial hypertension 2 | 32
Lung Neoplasms 2 | 232
Mood Disorders 2 | 184
Neoplasm Invasiveness 2 | 161
Psychotic Disorders 2 | 151
medulloblastoma 2 | 720

Tissue

Digestive Tract 25 | 17,369
Endocrine System 25 | 18,159
Liver and Pancreas 25 | 16,750
Male tissues 25 | 17,142
Skin and soft tissues 25 | 17,230
Blood and immune system 24 | 16,909
Female tissues 24 | 17,400
Nervous System 24 | 16,725
Respiratory system 24 | 16,393
Urinary Tract 24 | 16,678
Cardiovascular System 23 | 15,192

Target Family

Transcription Factor 20 | 1,400
Non-IDG 2 | 12,091
Enzyme 1 | 4,145
Epigenetic 1 | 242
Kinase 1 | 634

GO Function

bHLH transcription factor bind... 25 | 25
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitogen-activated protein kinase kinase kinase 10 MAP3K10 Tchem Kinase -1.20048 15.1 221
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.44791 277.6 405
Transcription factor E2-alpha TCF3 Tbio Transcription Factor -2.80290 601.6 434
Basic helix-loop-helix transcription factor scleraxis SCX Tbio Transcription Factor -2.84150 362.9 46
Insulin gene enhancer protein ISL-1 ISL1 Tbio Transcription Factor -2.63352 410.3 382
Runt-related transcription factor 2 RUNX2 Tbio Transcription Factor -3.40091 2392.3 631
Transcription factor 21 TCF21 Tbio Transcription Factor -1.80598 67.7 120
Class E basic helix-loop-helix protein 40 BHLHE40 Tbio Transcription Factor -1.77841 66.6 224
Transcription factor 12 TCF12 Tbio Transcription Factor -2.24606 159.8 253
Zinc finger protein Eos IKZF4 Tbio Transcription Factor -0.62342 3.32 135