Development Level

Tbio 4 | 11,445
Tchem 2 | 1,598

IMPC Phenotype

abnormal limb morphology 1 | 13
abnormal tail morphology 1 | 25
cyanosis 1 | 7
decreased basophil cell number 1 | 16
decreased vertical activity 1 | 208
edema 1 | 59
hemorrhage 1 | 23
preweaning lethality, complete... 1 | 979
respiratory system phenotype 1 | 2

Disease

osteosarcoma 5 | 7,950
ovarian cancer 4 | 8,520
Alzheimer's disease 3 | 658
Carcinoma 3 | 11,493
juvenile dermatomyositis 3 | 1,187
ALZHEIMER DISEASE 2 2 | 5
Alzheimer Disease 2 | 83
Alzheimer Disease 4 2 | 3
Amyloidosis 2 | 67
Amyotrophic lateral sclerosis 2 | 451
Asphyxia neonatorum 2 | 11
Breast cancer 2 | 3,578
Cardiomyopathy 2 | 116
Cardiomyopathy, Dilated 2 | 83
Congestive heart failure 2 | 113
Dementia 2 | 175
Dilated cardiomyopathy 2 | 56
Familial isolated dilated cardiomyopathy 2 | 41
Frontotemporal dementia 2 | 51
Heart failure 2 | 162
LEFT VENTRICULAR NONCOMPACTION 10 2 | 40
LEFT VENTRICULAR NONCOMPACTION 8 2 | 40
Neurodegenerative disease 2 | 414
Syncope 2 | 22
adult high grade glioma 2 | 3,801
atypical teratoid / rhabdoid tumor 2 | 5,112
ependymoma 2 | 4,679
glioblastoma 2 | 5,792
oligodendroglioma 2 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
pituitary cancer 2 | 1,972
ulcerative colitis 2 | 1,819
Abnormal brain FDG positron emission tomography 1 | 9
Alexia 1 | 6
Amnestic disorder 1 | 35
Anxiety 1 | 136
Anxiety disease 1 | 113
Apathy 1 | 16
Aphasia 1 | 26
Apraxia 1 | 26
Apraxias 1 | 27
Associative agnosia 1 | 2
Behavioral variant of frontotemporal dementia 1 | 8
Cerebral amyloid angiopathy 1 | 13
Chronic furunculosis 1 | 2
Chronic purulent otitis media 1 | 8
Compulsive hoarding 1 | 7
Conjunctivitis 1 | 53
Deglutition Disorders 1 | 132
Developmental arithmetic disorder 1 | 8
Difficulty making arithmetical calculations 1 | 8
Dysgraphia 1 | 20
Dyslexia 1 | 43
Dysphasia 1 | 23
EEG with continuous slow activity 1 | 7
Echolalia 1 | 12
Excess nuchal skin 1 | 30
Extrapyramidal Disorders 1 | 29
Extrapyramidal sign 1 | 29
Forgetful 1 | 40
Frontotemporal cerebral atrophy 1 | 8
Grammar-specific speech disorder 1 | 6
Granulomatous amebic encephalitis 1 | 8
Hyperorality 1 | 7
Hyperphagia 1 | 23
Increased appetite (finding) 1 | 23
Irritation - emotion 1 | 68
Language Disorders 1 | 13
Learning Disorders 1 | 29
Lower limb hyperreflexia 1 | 10
Memory Disorders 1 | 40
Memory Loss 1 | 40
Memory impairment 1 | 40
Myoclonus 1 | 74
Neurodegenerative Diseases 1 | 38
Neurodegenerative Disorders 1 | 79
Neurofibrillary degeneration (morphologic abnormality) 1 | 9
Parkinsonian Disorders 1 | 56
Pick's disease 1 | 15
Poor speech 1 | 37
Primary Progressive Nonfluent Aphasia 1 | 7
Primitive reflexes (palmomental, snout, glabellar) 1 | 7
Problems speaking 1 | 37
Prosopagnosia 1 | 4
Rapidly progressive 1 | 27
Rapidly progressive disorder 1 | 27
Recurrent cutaneous abscess formation 1 | 4
Repeated speech 1 | 9
Restlessness 1 | 14
Restrictive behavior 1 | 7
Restrictive behavior, interests, and activities 1 | 7
Semantic Dementia 1 | 7
Social disinhibition 1 | 14
Spastic tetraparesis 1 | 12
Spoken Word Recognition Deficit 1 | 6
Stereotyped Behavior 1 | 37
Stereotypic Movement Disorder 1 | 42
Temporal cortical atrophy 1 | 6
Visual agnosia 1 | 3
lingual-facial-buccal dyskinesia 1 | 13

Tissue

Blood and immune system 6 | 16,909
Cardiovascular System 6 | 15,192
Digestive Tract 6 | 17,369
Endocrine System 6 | 18,159
Female tissues 6 | 17,400
Liver and Pancreas 6 | 16,750
Male tissues 6 | 17,142
Nervous System 6 | 16,725
Respiratory system 6 | 16,393
Skin and soft tissues 6 | 17,230
Urinary Tract 6 | 16,678

Target Family

Enzyme 6 | 4,145

GO Function

aspartic endopeptidase activit... 6 | 6
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Presenilin-1 PSEN1 Tchem Enzyme -3.53128 3394.7 677
Signal peptide peptidase-like 2A SPPL2A Tbio Enzyme -1.34035 24.0 84
Minor histocompatibility antigen H13 HM13 Tbio Enzyme -2.48061 278.8 113
Signal peptide peptidase-like 3 SPPL3 Tbio Enzyme -1.36769 23.9 88
Presenilin-2 PSEN2 Tchem Enzyme -2.78856 585.9 310
Signal peptide peptidase-like 2B SPPL2B Tbio Enzyme 0.00000 45