Development Level

Tbio 10 | 11,445
Tdark 2 | 6,588

IMPC Phenotype

thrombocytosis 1 | 27

Disease

Carcinoma 10 | 11,493
osteosarcoma 7 | 7,950
glioblastoma 5 | 5,792
Chondrodysplasia punctata 4 | 41
Mucopolysaccharidosis 4 | 26
cystic fibrosis 4 | 1,696
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
malignant mesothelioma 4 | 3,232
tuberculosis 4 | 2,010
Astrocytoma, Pilocytic 3 | 3,081
Metachromatic leukodystrophy 3 | 14
Mucosulfatidosis 3 | 5
adrenocortical carcinoma 3 | 1,428
interstitial cystitis 3 | 2,312
invasive ductal carcinoma 3 | 2,951
ovarian cancer 3 | 8,520
pancreatic cancer 3 | 2,398
primary pancreatic ductal adenocarcinoma 3 | 1,109
psoriasis 3 | 6,694
Attention deficit hyperactivity disorder 2 | 278
Autosomal recessive predisposition 2 | 1,442
Breast cancer 2 | 3,578
Cancer 2 | 2,499
Concave bridge of nose 2 | 195
Congenital deafness 2 | 185
Deafness 2 | 198
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Hearing Loss, Partial 2 | 185
Ichthyosis 2 | 56
Leukodystrophy 2 | 55
X-linked cerebral adrenoleukodystrophy 2 | 116
active Crohn's disease 2 | 922
active ulcerative colitis 2 | 764
astrocytic glioma 2 | 2,597
ductal carcinoma in situ 2 | 1,745
ependymoma 2 | 4,679
gastric carcinoma 2 | 807
hearing impairment 2 | 199
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
lung adenocarcinoma 2 | 2,716
lung cancer 2 | 4,740
lung carcinoma 2 | 2,843
medulloblastoma, large-cell 2 | 6,241
non primary Sjogren syndrome sicca 2 | 891
non-small cell lung cancer 2 | 2,890
pediatric high grade glioma 2 | 1,064
pituitary cancer 2 | 1,972
primitive neuroectodermal tumor 2 | 3,035
Abnormal gallbladder function 1 | 1
Big calvaria 1 | 147
Bulbar palsy 1 | 19
Bulbar weakness 1 | 19
Cardiomyopathies 1 | 110
Cerebrospinal fluid protein increased above normal 1 | 14
Cholecystitis 1 | 18
Cloudy cornea 1 | 33
Corneal stromal opacities 1 | 33
Cortical white matter abnormalities seen on MRI 1 | 18
Decreased nerve conduction velocity 1 | 35
Delusions 1 | 11
EMG: neuropathic changes 1 | 15
Flared iliac wings 1 | 13
Gangliosidosis 1 | 20
Gaucher's disease 1 | 26
Hallucinations 1 | 34
Hallucinations, Sensory 1 | 33
Heart valve disease 1 | 39
Hirsutism 1 | 47
Increased size of cranium 1 | 147
Joint stiffness 1 | 84
Knee joint valgus deformity 1 | 56
Krabbe disease 1 | 12
Leukoaraiosis 1 | 18
Leukodystrophy, Metachromatic 1 | 1
Loss of speech 1 | 16
Mental deterioration 1 | 32
Metachromatic Leukodystrophy, Adult-Type (disorder) 1 | 2
Metachromatic leukodystrophy, juvenile type 1 | 2
Mood swings 1 | 77
Nager acrofacial dysostosis 1 | 21
Narrow cranium shape 1 | 75
Narrow head shape 1 | 75
Narrow skull shape 1 | 75
Neuronal ceroid lipofuscinosis 1 | 28
Ovarian Neoplasms 1 | 102
Peripheral demyelination 1 | 16
Pfaundler-Hurler Syndrome 1 | 12
Progressive peripheral neuropathy 1 | 3
Recurrent upper respiratory tract infection 1 | 21
Relapsing fever 1 | 14
Scotoma 1 | 22
Spastic Quadriplegia 1 | 42
Tinea capitis 1 | 14
Turridolichocephaly 1 | 75
Urinary Incontinence 1 | 50
X- linked recessive 1 | 110
inclusion-cell disease 1 | 16
non-small cell lung carcinoma 1 | 317
ovarian neoplasm 1 | 99

Tissue

Digestive Tract 12 | 17,369
Female tissues 12 | 17,400
Liver and Pancreas 12 | 16,750
Male tissues 12 | 17,142
Skin and soft tissues 12 | 17,230
Urinary Tract 12 | 16,678
Blood and immune system 11 | 16,909
Endocrine System 11 | 18,159
Nervous System 11 | 16,725
Respiratory system 11 | 16,393
Cardiovascular System 10 | 15,192

Target Family

Enzyme 12 | 4,145

GO Function

arylsulfatase activity 12 | 12
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Arylsulfatase F ARSF Tbio Enzyme -0.44326 2.74 138
Extracellular sulfatase Sulf-2 SULF2 Tbio Enzyme -1.74398 67.0 221
Extracellular sulfatase Sulf-1 SULF1 Tbio Enzyme -1.90276 92.2 61
Arylsulfatase J ARSJ Tdark Enzyme -0.22432 1.18 25
Arylsulfatase H ARSH Tbio Enzyme -2.14770 118.6 81
Arylsulfatase B ARSB Tbio Enzyme -2.51626 314.5 216
Arylsulfatase D ARSD Tbio Enzyme -2.09545 123.1 132
Arylsulfatase A ARSA Tbio Enzyme -2.50334 319.0 337
Arylsulfatase I ARSI Tbio Enzyme -2.01048 99.4 129
Arylsulfatase E ARSE Tbio Enzyme -2.94926 879.7 73