Development Level

Tbio 4 | 11,651
Tchem 1 | 1,388
Tdark 1 | 6,593

IMPC Phenotype

preweaning lethality, complete... 4 | 979
embryonic lethality prior to t... 3 | 278
embryonic lethality prior to o... 2 | 239
abnormal embryo size 1 | 220
abnormal heart morphology 1 | 162
abnormal placenta size 1 | 20
decreased circulating glucose ... 1 | 126
enlarged heart 1 | 210
increased circulating glucose ... 1 | 24
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

Carcinoma 6 | 11,493
Breast cancer 4 | 3,578
atypical teratoid / rhabdoid tumor 4 | 5,112
medulloblastoma, large-cell 4 | 6,241
osteosarcoma 4 | 7,950
psoriasis 4 | 6,694
Cancer 3 | 2,499
Kidney cancer 3 | 2,613
adult high grade glioma 3 | 3,801
breast carcinoma 3 | 1,638
glioblastoma 3 | 5,792
invasive ductal carcinoma 3 | 2,951
lung adenocarcinoma 3 | 2,716
non-small cell lung cancer 3 | 2,890
ovarian cancer 3 | 8,520
Endometriosis 2 | 540
Glioma 2 | 74
Leukemia 2 | 104
lung cancer 2 | 4,740
malignant mesothelioma 2 | 3,232
nasopharyngeal carcinoma 2 | 1,058
pancreatic cancer 2 | 2,398
Abnormal lung lobation 1 | 10
Abnormal subcutaneous fat tissue distribution 1 | 3
Abnormal vertebral bodies 1 | 16
Abnormality of the penis 1 | 7
Abnormally prominent line of Schwalbe 1 | 2
Action Tremor 1 | 22
Angioid streaks 1 | 11
Aqueductal Stenosis 1 | 5
Asbestosis 1 | 20
Asymmetric chest 1 | 4
Bannayan-Riley-Ruvalcaba syndrome 1 | 8
Benign neoplasm of eye, unspecified 1 | 3
Birth length greater than 97th percentile 1 | 5
Cafe au lait spots, multiple 1 | 17
Calvarial hyperostosis 1 | 5
Congenital anomaly of spine 1 | 16
Congenital bronchogenic cyst 1 | 3
Conjunctival hamartoma 1 | 7
Cowden disease 1 | 18
Cowden syndrome 1 1 | 2
Cranial nerve palsies 1 | 11
Decreased muscle mass 1 | 28
Dermoid choristoma of eye proper 1 | 3
Endometrial Hyperplasia 1 | 5
Enlarged cerebellum 1 | 3
Enlargement of calvarial bones 1 | 5
Excessive wrinkled skin 1 | 16
Exostoses 1 | 11
Familial meningioma 1 | 4
Fibrous skin tumor of tuberous sclerosis 1 | 18
Fissured tongue 1 | 25
Gastrointestinal hamartomatous polyps 1 | 10
Gastrointestinal polyps 1 | 5
Haemorrhage subcutaneous 1 | 10
Hamartoma Syndrome, Multiple 1 | 10
Hamartomatous polyp 1 | 10
Hand polydactyly 1 | 11
Hashimoto Disease 1 | 4
Hepatocellular Adenoma 1 | 10
Heterochromia iridis 1 | 9
Hyperkeratosis, generalized 1 | 14
Hyperostosis 1 | 18
Increased ossification of calvarial bones 1 | 5
Increased size of penis 1 | 7
Intestinal Polyposis 1 | 6
Intussusception 1 | 5
LEOPARD syndrome 1 | 20
Leg Length Inequality 1 | 6
Lipomatosis 1 | 12
MACROCEPHALY/AUTISM SYNDROME 1 | 2
Macrocephaly, postnatal 1 | 2
Macule 1 | 19
Marfanoid body habitus 1 | 11
Meningioma, familial 1 | 6
Mucosal telangiectasiae 1 | 14
Multiple lipomata 1 | 7
Multiple vertebral anomalies 1 | 16
Multiple, subcutaneous nodules 1 | 53
NEVUS, EPIDERMAL (disorder) 1 | 5
Numerous nevi 1 | 5
Papule 1 | 43
Polyp of large intestine 1 | 8
Postnatal growth retardation 1 | 57
Proteus syndrome 1 | 6
Pupillary abnormality 1 | 4
Shagreen patch 1 | 3
Subcutaneous lipomas 1 | 9
Subcutaneous nodule 1 | 53
Terminal tremor 1 | 20
Testicular Hydrocele 1 | 8
Thumb aplasia 1 | 16
Thyroid Cancer, Nonmedullary, 2 1 | 6
Thyroid Gland Follicular Adenoma 1 | 9
Thyroid adenoma 1 | 10
Thyroid cancer, follicular 1 | 8
Thyroiditis 1 | 29
Transient tic disorder 1 | 2
VACTERL Association With Hydrocephalus 1 | 3

Tissue

Endocrine System 6 | 18,159
Female tissues 6 | 17,400
Male tissues 6 | 17,142
Respiratory system 6 | 16,393
Urinary Tract 6 | 16,678
Blood and immune system 5 | 16,909
Digestive Tract 5 | 17,369
Liver and Pancreas 5 | 16,750
Nervous System 5 | 16,725
Skin and soft tissues 5 | 17,230
Cardiovascular System 4 | 15,192

Target Family

Non-IDG 4 | 12,091
Enzyme 1 | 4,145
Kinase 1 | 634

GO Function

anaphase-promoting complex bin... 6 | 6
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cell division cycle protein 20 homolog B CDC20B Tdark Non-IDG -0.47873 2.05 122
Fizzy-related protein homolog FZR1 Tbio Non-IDG -1.78590 63.2 228
Serine/threonine-protein kinase PLK1 PLK1 Tchem Kinase -3.09610 1271.1 856
Cell division cycle protein 20 homolog CDC20 Tbio Non-IDG -2.60409 401.5 393
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN PTEN Tbio Enzyme -3.70874 5099.6 916
Claspin CLSPN Tbio Non-IDG -1.76624 62.6 74