Development Level

Tchem 19 | 1,598
Tbio 6 | 11,445
Tdark 1 | 6,588

IMPC Phenotype

decreased circulating phosphat... 2 | 27
decreased circulating triglyce... 2 | 79
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal cranium morphology 1 | 36
abnormal femur morphology 1 | 14
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal radius morphology 1 | 8
abnormal tail morphology 1 | 25
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 18
abnormal vertebral arch morpho... 1 | 9
decreased IgE level 1 | 6
decreased IgG1 level 1 | 8
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased body weight 1 | 161
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
hypoactivity 1 | 132
increased CD4-positive, CD25-p... 1 | 1
increased KLRG1-positive NK ce... 1 | 1
increased NK cell number 1 | 3
increased anti-nuclear antigen... 1 | 19
increased cardiac muscle contr... 1 | 8
increased circulating alkaline... 1 | 122
increased circulating creatini... 1 | 38
increased circulating potassiu... 1 | 29
increased circulating serum al... 1 | 22
increased effector memory CD4-... 1 | 1
increased heart weight 1 | 62
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
long tail 1 | 1
mammalian phenotype 1 | 17
preweaning lethality, complete... 1 | 979
thick tail 1 | 1

Disease

Carcinoma 22 | 11,493
ovarian cancer 16 | 8,520
osteosarcoma 13 | 7,950
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
lung cancer 10 | 4,740
glioblastoma 9 | 5,792
psoriasis 9 | 6,694
atypical teratoid / rhabdoid tumor 8 | 5,112
group 3 medulloblastoma 8 | 4,104
medulloblastoma, large-cell 8 | 6,241
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
lung carcinoma 7 | 2,843
malignant mesothelioma 7 | 3,232
Kidney cancer 6 | 2,613
adult high grade glioma 6 | 3,801
ependymoma 6 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
non-small cell lung cancer 6 | 2,890
tuberculosis 6 | 2,010
Breast cancer 5 | 3,578
cystic fibrosis 5 | 1,696
invasive ductal carcinoma 5 | 2,951
oligodendroglioma 5 | 2,850
Astrocytoma, Pilocytic 4 | 3,081
Liver Cirrhosis, Experimental 4 | 769
Pick disease 4 | 1,894
ductal carcinoma in situ 4 | 1,745
esophageal adenocarcinoma 4 | 737
lung adenocarcinoma 4 | 2,716
nephrosclerosis 4 | 333
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
primitive neuroectodermal tumor 4 | 3,035
spina bifida 4 | 1,074
ulcerative colitis 4 | 1,819
Asthma 3 | 385
Hypertension 3 | 396
Multiple myeloma 3 | 1,332
active Crohn's disease 3 | 922
active ulcerative colitis 3 | 764
acute myeloid leukemia 3 | 783
acute quadriplegic myopathy 3 | 1,158
astrocytic glioma 3 | 2,597
astrocytoma 3 | 1,146
diabetes mellitus 3 | 1,728
interstitial cystitis 3 | 2,312
juvenile dermatomyositis 3 | 1,187
non primary Sjogren syndrome sicca 3 | 891
pancreatic cancer 3 | 2,398
primary pancreatic ductal adenocarcinoma 3 | 1,109
Acquired metabolic disease 2 | 336
Anemia 2 | 365
Ankylosing spondylitis 2 | 140
Arthralgia 2 | 90
Atopic dermatitis 2 | 952
Bacterial vaginosis 2 | 15
Behcet's disease 2 | 89
Bipolar Disorder 2 | 666
Cancer 2 | 2,499
Common variable immunodeficiency 2 | 101
Crohn's disease 2 | 321
Hemiparesis 2 | 34
Hypothyroidism 2 | 122
Lupus Erythematosus, Systemic 2 | 67
Major Depressive Disorder 2 | 301
Mammary Neoplasms, Experimental 2 | 154
Papule 2 | 43
Polycystic ovary syndrome 2 | 360
Rheumatoid arthritis 2 | 1,191
Splenomegaly 2 | 190
Thrombocytopenia 2 | 197
Unipolar Depression 2 | 250
adrenocortical carcinoma 2 | 1,428
breast carcinoma 2 | 1,638
cutaneous lupus erythematosus 2 | 1,057
dermatomyositis 2 | 966
group 4 medulloblastoma 2 | 1,855
interstitial lung disease 2 | 298
pediatric high grade glioma 2 | 1,064
pituitary cancer 2 | 1,972
posterior fossa group A ependymoma 2 | 468
sonic hedgehog group medulloblastoma 2 | 467
tuberculosis and treatment for 6 months 2 | 409
Amyloidosis 1 | 67
Babesiosis 1 | 14
Behcet's syndrome 1 | 50
Birdshot chorioretinopathy 1 | 23
Convex nasal ridge 1 | 37
Cystic kidney disease 1 | 26
Evans' syndrome 1 | 3
Fascioliasis 1 | 17
Gastrointestinal Hemorrhage 1 | 52
Hepatitis 1 | 67
Idiopathic pulmonary fibrosis 1 | 23
Memory Disorders 1 | 40
Metaphyseal irregularity 1 | 23
Personality disorder 1 | 25
Photosensitivity of skin 1 | 51
Psoriatic arthritis 1 | 86
Pulmonary Fibrosis, Idiopathic 1 | 12
Vulvovaginitis 1 | 6

Tissue

Blood and immune system 26 | 16,909
Digestive Tract 26 | 17,369
Endocrine System 26 | 18,159
Female tissues 26 | 17,400
Liver and Pancreas 26 | 16,750
Male tissues 26 | 17,142
Nervous System 26 | 16,725
Respiratory system 26 | 16,393
Skin and soft tissues 26 | 17,230
Urinary Tract 26 | 16,678
Cardiovascular System 25 | 15,192

Target Family

Enzyme 26 | 4,145

GO Function

aminopeptidase activity 26 | 26
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Aminopeptidase N ANPEP Tchem Enzyme -3.28127 1843.4 1222
Endoplasmic reticulum aminopeptidase 2 ERAP2 Tchem Enzyme -1.73764 53.1 76
Probable aminopeptidase NPEPL1 NPEPL1 Tdark Enzyme 0.12 0.49 52
Cytosol aminopeptidase LAP3 Tchem Enzyme -2.59176 385.7 172
Methionine aminopeptidase 1 METAP1 Tchem Enzyme -1.64901 44.4 149
Xaa-Pro aminopeptidase 2 XPNPEP2 Tchem Enzyme -1.61390 35.9 110
Aminopeptidase B RNPEP Tchem Enzyme -2.88402 763.4 140
Pro-cathepsin H CTSH Tchem Enzyme -2.36930 222.0 253
Xaa-Pro dipeptidase PEPD Tchem Enzyme -2.97538 963.8 157
Leukotriene A-4 hydrolase LTA4H Tchem Enzyme -2.11151 125.3 291