Development Level

Tbio 5 | 11,445

IMPC Phenotype

abnormal behavior 1 | 298
abnormal cornea morphology 1 | 31
abnormal gait 1 | 69
corneal opacity 1 | 32
decreased grip strength 1 | 116
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
hyperactivity 1 | 148
hypoactivity 1 | 132
increased fasted circulating g... 1 | 76
increased mean corpuscular vol... 1 | 92
limb grasping 1 | 41

Disease

Autosomal recessive predisposition 4 | 1,442
Carcinoma 3 | 11,493
Seizures 3 | 596
active ulcerative colitis 3 | 764
astrocytoma 3 | 1,146
glioblastoma 3 | 5,792
lung cancer 3 | 4,740
ovarian cancer 3 | 8,520
Atopic dermatitis 2 | 952
Breast cancer 2 | 3,578
Cerebral atrophy 2 | 178
Cognitive delay 2 | 608
Degenerative brain disorder 2 | 100
Down syndrome 2 | 499
Epilepsy 2 | 792
Global developmental delay 2 | 608
Mental and motor retardation 2 | 608
Muscle Spasticity 2 | 195
Muscle hypotonia 2 | 571
Nystagmus 2 | 317
Obesity 2 | 678
Precancerous Conditions 2 | 80
acute quadriplegic myopathy 2 | 1,158
adrenocortical carcinoma 2 | 1,428
breast carcinoma 2 | 1,638
ductal carcinoma in situ 2 | 1,745
ependymoma 2 | 4,679
fibroadenoma 2 | 559
invasive ductal carcinoma 2 | 2,951
lung adenocarcinoma 2 | 2,716
lung carcinoma 2 | 2,843
non-small cell lung cancer 2 | 2,890
osteosarcoma 2 | 7,950
psoriasis 2 | 6,694
Abnormal vision 1 | 52
Abnormal visual evoked potential 1 | 26
Acute Lung Injury 1 | 22
Acute encephalopathy 1 | 4
Argininosuccinic aciduria 1 | 17
Arthritis, Experimental 1 | 39
Axial hypotonia 1 | 46
Behcet Syndrome 1 | 21
Biotinidase deficiency 1 | 14
Breast Neoplasms 1 | 445
CNS hypomyelination 1 | 17
Canavan disease 1 | 10
Carcinoma, Non-Small-Cell Lung 1 | 107
Carcinoma, Renal Cell 1 | 124
Cardiomyopathies 1 | 110
Cell Transformation, Neoplastic 1 | 97
Central nervous system demyelination 1 | 28
Chemical and Drug Induced Liver Injury 1 | 195
Chromosome Breakage 1 | 36
Comatose 1 | 56
Cowpox 1 | 16
Deglutition Disorders 1 | 132
Diabetes Mellitus, Experimental 1 | 108
Diabetes Mellitus, Insulin-Dependent 1 | 48
Diabetes Mellitus, Type 1 1 | 43
Diabetic Neuropathies 1 | 14
Diffuse large B-cell lymphoma 1 | 39
Edema 1 | 81
Fatty Liver 1 | 70
Glioma 1 | 74
Greig cephalopolysyndactyly syndrome 1 | 3
Heart failure 1 | 162
Hepatitis 1 | 67
Hepatitis, Chronic 1 | 23
Hyperactive behavior 1 | 91
Hyperglycemia 1 | 137
Hyperthyroidism 1 | 53
Hypomyelination 1 | 17
Hypotension 1 | 82
Keratosis 1 | 37
Kidney Calculi 1 | 7
Kidney Failure, Chronic 1 | 46
Lethargy 1 | 77
Leukodystrophy 1 | 55
Leukoencephalopathies 1 | 29
Liver disease 1 | 237
Lupus Erythematosus, Systemic 1 | 67
Lymphoma, Large B-Cell, Diffuse 1 | 34
Mammary Neoplasms 1 | 425
Mild global developmental delay 1 | 14
Muscle Weakness 1 | 170
Myocardial Infarction 1 | 151
Myocardial Reperfusion Injury 1 | 37
Necrosis 1 | 53
Neoplasm Metastasis 1 | 168
Neoplasms 1 | 63
Neoplastic Cell Transformation 1 | 89
Psychomotor retardation, mild 1 | 14
Pulmonary Fibrosis 1 | 106
Pulmonary edema 1 | 17
Pulmonary embolism 1 | 55
Renal Cell Carcinoma 1 | 214
Sialuria 1 | 9
Sleep disturbances 1 | 37
Supratentorial atrophy 1 | 94
non-small cell lung carcinoma 1 | 317

Tissue

Blood and immune system 5 | 16,909
Digestive Tract 5 | 17,369
Endocrine System 5 | 18,159
Female tissues 5 | 17,400
Liver and Pancreas 5 | 16,750
Male tissues 5 | 17,142
Nervous System 5 | 16,725
Respiratory system 5 | 16,393
Skin and soft tissues 5 | 17,230
Urinary Tract 5 | 16,678
Cardiovascular System 4 | 15,192

Target Family

Enzyme 5 | 4,145

GO Function

aminoacylase activity 5 | 5
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Aspartate--tRNA ligase, cytoplasmic DARS Tbio Enzyme -1.93573 78.1 128
N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) ACY3 Tbio Enzyme -0.86435 6.57 152
Catalase CAT Tbio Enzyme -3.63626 3427.5 629
Aminoacylase-1 ACY1 Tbio Enzyme -2.00409 100.3 313
Aspartoacylase ASPA Tbio Enzyme -2.04271 107.1 151