Development Level

Tclin 3 | 613

IMPC Phenotype

abnormal behavior 1 | 298
decreased fasted circulating g... 1 | 65
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
hyperactivity 1 | 148
improved glucose tolerance 1 | 79

Disease

Acute exacerbation of asthma 3 | 14
Administration of Local Anesthetic Nerve Block 3 | 14
Allergic Reactions 3 | 7
Asthma management 3 | 19
Attention deficit hyperactivity disorder 3 | 278
Bronchiectasis 3 | 64
Bronchitis 3 | 43
Cerebral Ischemia 3 | 37
Cerebrovascular Occlusion 3 | 5
Cerebrovascular disease 3 | 238
Conscious sedation 3 | 10
Dermal Necrosis 3 | 6
Diagnostic Test for Pheochromocytoma 3 | 6
Disorder of blood vessel 3 | 4
Dyspnea 3 | 76
Exacerbation of asthma 3 | 11
Hypertension Secondary to Pheochromocytoma 3 | 6
Hypertensive Emergencies 3 | 10
Hypertensive disorder 3 | 56
Increased Intraocular Pressure after Ocular Procedure 3 | 3
Local anesthesia, by infiltration 3 | 14
Low blood pressure 3 | 9
Muscle Spasticity of Cerebral Origin 3 | 8
Muscle spasticity of spinal origin 3 | 8
Nasal congestion 3 | 21
Nasal discharge 3 | 24
Ocular Itching 3 | 4
Ocular hypertension 3 | 42
Open-angle glaucoma 3 | 27
Orthostatic hypotension 3 | 9
Parkinson's disease 3 | 392
Paroxysmal hypertension 3 | 6
Percutaneous coronary intervention 3 | 9
Peripheral vascular disease 3 | 87
Persistent pulmonary hypertension of the newborn 3 | 8
Pheochromocytoma 3 | 24
Prevention of Cerebral Thrombosis 3 | 29
Prevention of Hypertension in Pheochromocytoma 3 | 6
Pulmonary emphysema 3 | 48
Red eye 3 | 7
Rosacea 3 | 25
Severe pain 3 | 11
Spasticity 3 | 26
Subacute Stent Thrombosis Prevention 3 | 5
Wheezing 3 | 7
anaphylaxis 3 | 11
psoriasis 3 | 6,694
Asthma 2 | 385
Carcinoma 2 | 11,493
Cardiomegaly 2 | 116
Epilepsy 2 | 792
Fibrosis 2 | 44
Gilles de la Tourette syndrome 2 | 47
Hypertension 2 | 396
Mood Disorders 2 | 184
adult high grade glioma 2 | 3,801
fibroadenoma 2 | 559
glioblastoma 2 | 5,792
lung cancer 2 | 4,740
ovarian cancer 2 | 8,520
primitive neuroectodermal tumor 2 | 3,035
Acquired metabolic disease 1 | 336
Adult onset 1 | 82
African tick-bite fever 1 | 2
Alcoholic Intoxication, Chronic 1 | 289
Benign adult familial myoclonic epilepsy 1 | 2
Bipolar Disorder 1 | 666
Blepharospasm 1 | 13
Coronary artery disease 1 | 268
Cyanosis 1 | 17
Depressive disorder 1 | 409
Disease of mental health 1 | 36
EPILEPSY, FAMILIAL ADULT MYOCLONIC, 1 1 | 2
Electroencephalogram abnormal 1 | 101
Familial partial lipodystrophy 1 | 12
Generalized seizures 1 | 9
Generalized seizures, recurrent 1 | 9
Heart Diseases 1 | 43
Heart failure 1 | 162
Hypotension 1 | 82
Local anesthesia 1 | 40
Lung diseases 1 | 50
Mental Depression 1 | 333
Myoclonus 1 | 74
Nonprogressive 1 | 12
Opioid withdrawal 1 | 2
Pain agnosia 1 | 104
Panic disorder 1 | 61
Persistent erythema of skin 1 | 2
Seizures, Focal 1 | 14
Tonic - clonic seizures 1 | 44
Tremor 1 | 113
Tremor of hands 1 | 3
Type 2 diabetes mellitus 1 | 272
astrocytoma 1 | 1,146
breast carcinoma 1 | 1,638
cystic fibrosis 1 | 1,696
lung adenocarcinoma 1 | 2,716
pituitary cancer 1 | 1,972
uncontrolled asthma 1 | 56

Tissue

Blood and immune system 3 | 16,909
Cardiovascular System 3 | 15,192
Digestive Tract 3 | 17,369
Endocrine System 3 | 18,159
Female tissues 3 | 17,400
Liver and Pancreas 3 | 16,750
Male tissues 3 | 17,142
Nervous System 3 | 16,725
Respiratory system 3 | 16,393
Skin and soft tissues 3 | 17,230
Urinary Tract 3 | 16,678

Target Family

GPCR 3 | 408

GO Function

alpha2-adrenergic receptor act... 3 | 3
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Alpha-2A adrenergic receptor ADRA2A Tclin GPCR -2.42160 261.4 232
Alpha-2B adrenergic receptor ADRA2B Tclin GPCR -2.15839 139.8 0
Alpha-2C adrenergic receptor ADRA2C Tclin GPCR -1.97108 93.5 343