Development Level

Tbio 6 | 11,445
Tchem 5 | 1,598
Tclin 1 | 613

IMPC Phenotype

abnormal embryo size 3 | 220
abnormal bone structure 2 | 187
decreased startle reflex 2 | 75
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
preweaning lethality, complete... 2 | 979
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal coat- hair morphology 1 | 19
abnormal craniofacial morpholo... 1 | 33
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal liver morphology 1 | 17
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal seminal vesicle morph... 1 | 114
abnormal testis morphology 1 | 43
anophthalmia 1 | 33
decreased blood urea nitrogen ... 1 | 51
enlarged heart 1 | 210
enlarged testis 1 | 6
increased prepulse inhibition 1 | 32
microphthalmia 1 | 26
pale yolk sac 1 | 25
pallor 1 | 34
small adrenal glands 1 | 16
small superior vagus ganglion 1 | 74
small testis 1 | 58
trunk curl 1 | 16

Disease

Cancer 8 | 2,499
osteosarcoma 8 | 7,950
Carcinoma 7 | 11,493
ovarian cancer 7 | 8,520
glioblastoma 6 | 5,792
non-small cell lung cancer 6 | 2,890
psoriasis 6 | 6,694
ulcerative colitis 6 | 1,819
adult high grade glioma 5 | 3,801
atypical teratoid / rhabdoid tumor 5 | 5,112
interstitial cystitis 5 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
invasive ductal carcinoma 5 | 2,951
lung carcinoma 5 | 2,843
cystic fibrosis 4 | 1,696
lung adenocarcinoma 4 | 2,716
lung cancer 4 | 4,740
malignant mesothelioma 4 | 3,232
medulloblastoma, large-cell 4 | 6,241
subependymal giant cell astrocytoma 4 | 2,287
tuberculosis 4 | 2,010
Atopic dermatitis 3 | 952
Breast cancer 3 | 3,578
Kidney cancer 3 | 2,613
Pick disease 3 | 1,894
acute quadriplegic myopathy 3 | 1,158
astrocytic glioma 3 | 2,597
breast carcinoma 3 | 1,638
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
primitive neuroectodermal tumor 3 | 3,035
ANEURYSM, INTRACRANIAL BERRY, 1 (disorder) 2 | 3
Anemia 2 | 365
Angiodysplasia 2 | 5
Angioectasias of the tongue 2 | 2
Arteriovenous Malformations, Cerebral 2 | 2
Arteriovenous malformation 2 | 6
Arteriovenous malformation of liver 2 | 2
Astrocytoma, Pilocytic 2 | 3,081
Brain Abscess 2 | 2
Brain hemorrhage 2 | 14
Breast Neoplasms 2 | 445
Cerebral Hemorrhage 2 | 42
Cholecystitis 2 | 18
Clubbing 2 | 9
Conjunctival telangiectasis 2 | 14
Cyanosis 2 | 17
Dyspnea 2 | 76
Epilepsy 2 | 792
Epistaxis 2 | 43
Erythrocytosis 2 | 8
Familial primary pulmonary hypertension 2 | 11
Feces color: tarry 2 | 2
Finger pad telangiectases 2 | 2
Gastrointestinal angiodysplasia 2 | 3
Gastrointestinal arteriovenous malformation 2 | 2
Gastrointestinal telangiectasia 2 | 2
Heart disease 2 | 306
Hemangioma, Cavernous 2 | 20
Hematemesis 2 | 4
Hematochezia 2 | 9
Hemoglobin low 2 | 124
Hereditary hemorrhagic telangiectasia 2 | 13
Hypertension 2 | 396
Hypertension, Portal 2 | 22
Intermittent migraine headaches 2 | 68
Iron-Refractory Iron Deficiency Anemia 2 | 15
Ischemic stroke 2 | 4
Lip telangiectases 2 | 4
Liver Cirrhosis 2 | 181
Mammary Neoplasms 2 | 425
Melena 2 | 2
Migraine Disorders 2 | 76
Multiple synostoses syndrome 2 | 9
Myopathy 2 | 185
Nail bed telangiectases 2 | 2
Nasal mucosa telangiectasia 2 | 2
Palatal spider veins 2 | 2
Palate telangiectases 2 | 2
Polycythemia 2 | 25
Primary pulmonary hypertension 2 | 14
Pulmonary arteriovenous malformation 2 | 2
Right to left cardiovascular shunt (finding) 2 | 3
Seizures 2 | 596
Spider veins of the lip 2 | 4
Spinal arteriovenous malformation 2 | 2
Spontaneous haematoma 2 | 8
Spontaneous, recurrent epistaxis 2 | 3
Subarachnoid Hemorrhage 2 | 7
Telangiectasia of the skin 2 | 39
Telangiectasis 2 | 36
Tongue telangiectasia 2 | 2
Transient Cerebral Ischemia 2 | 25
Visceral angiomatosis 2 | 13
acute myeloid leukemia 2 | 783
astrocytoma 2 | 1,146
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
group 3 medulloblastoma 2 | 4,104
juvenile dermatomyositis 2 | 1,187
pituitary cancer 2 | 1,972

Tissue

Blood and immune system 12 | 16,909
Cardiovascular System 12 | 15,192
Digestive Tract 12 | 17,369
Endocrine System 12 | 18,159
Female tissues 12 | 17,400
Liver and Pancreas 12 | 16,750
Male tissues 12 | 17,142
Nervous System 12 | 16,725
Respiratory system 12 | 16,393
Skin and soft tissues 12 | 17,230
Urinary Tract 12 | 16,678

Target Family

Kinase 5 | 634
Non-IDG 4 | 12,091
Enzyme 2 | 4,145
Transcription Factor 1 | 1,400

GO Function

activin binding 12 | 12
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endoglin ENG Tbio Non-IDG -3.10482 1235.9 1622
Activin receptor type-2A ACVR2A Tchem Kinase -2.08745 108.0 315
Activin receptor type-1B ACVR1B Tchem Kinase -2.00550 91.2 418
Follistatin-related protein 3 FSTL3 Tbio Non-IDG -1.80964 76.6 138
Follistatin FST Tbio Non-IDG -3.07812 1179.4 356
Transforming growth factor beta receptor type 3 TGFBR3 Tbio Non-IDG -1.92250 80.6 270
Serine/threonine-protein kinase receptor R3 ACVRL1 Tchem Kinase -2.98370 969.8 432
E3 ubiquitin-protein ligase SMURF1 SMURF1 Tbio Enzyme -1.95365 89.3 331
Activin receptor type-2B ACVR2B Tchem Kinase -2.14321 122.9 303
Peptidyl-prolyl cis-trans isomerase FKBP1A FKBP1A Tclin Enzyme -2.77923 382.8 271