Development Level

Tbio 23 | 11,445
Tclin 4 | 613
Tchem 3 | 1,598

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 4 | 979
prenatal lethality prior to he... 3 | 87
embryonic lethality prior to t... 2 | 278
abnormal cranium morphology 1 | 36
abnormal ear morphology 1 | 9
abnormal facial morphology 1 | 17
abnormal gait 1 | 69
abnormal lens morphology 1 | 81
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
corneal opacity 1 | 32
embryonic lethality prior to o... 1 | 239
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased hemoglobin content 1 | 45

Disease

Carcinoma 20 | 11,493
osteosarcoma 16 | 7,950
ovarian cancer 16 | 8,520
psoriasis 16 | 6,694
Cancer 15 | 2,499
glioblastoma 15 | 5,792
lung cancer 15 | 4,740
ependymoma 14 | 4,679
medulloblastoma, large-cell 14 | 6,241
atypical teratoid / rhabdoid tumor 13 | 5,112
adult high grade glioma 12 | 3,801
group 3 medulloblastoma 12 | 4,104
primitive neuroectodermal tumor 12 | 3,035
Multiple myeloma 10 | 1,332
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
oligodendroglioma 10 | 2,850
Breast cancer 9 | 3,578
Astrocytoma, Pilocytic 8 | 3,081
Intellectual disability 8 | 1,016
acute quadriplegic myopathy 7 | 1,158
invasive ductal carcinoma 7 | 2,951
lung adenocarcinoma 7 | 2,716
non-small cell lung cancer 7 | 2,890
Dull intelligence 6 | 645
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Poor school performance 6 | 645
Waldenstrons macroglobulinemia 6 | 765
group 4 medulloblastoma 6 | 1,855
pancreatic cancer 6 | 2,398
subependymal giant cell astrocytoma 6 | 2,287
Epilepsy 5 | 792
Kidney cancer 5 | 2,613
Schizophrenia 5 | 1,160
Seizures 5 | 596
astrocytic glioma 5 | 2,597
diabetes mellitus 5 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
lung carcinoma 5 | 2,843
malignant mesothelioma 5 | 3,232
Liver Cirrhosis, Experimental 4 | 769
Mood Disorders 4 | 184
Muscle hypotonia 4 | 571
Obesity 4 | 678
Parkinson's disease 4 | 392
Short stature 4 | 531
Small head 4 | 374
Stomach Neoplasms 4 | 300
active ulcerative colitis 4 | 764
astrocytoma 4 | 1,146
breast carcinoma 4 | 1,638
interstitial cystitis 4 | 2,312
pediatric high grade glioma 4 | 1,064
ulcerative colitis 4 | 1,819
Adenocarcinoma of lung 3 | 142
Adenoma 3 | 167
Amyotrophic lateral sclerosis 3 | 451
Autosomal recessive predisposition 3 | 1,442
Bilateral fifth finger clinodactyly 3 | 110
Bladder Neoplasm 3 | 112
Cognitive delay 3 | 608
Colonic Neoplasms 3 | 142
Congenital heart disease 3 | 93
Curvature of little finger 3 | 110
Diabetes Mellitus, Non-Insulin-Dependent 3 | 145
Diabetes Mellitus, Type 2 3 | 142
Failure to gain weight 3 | 365
Global developmental delay 3 | 608
Heart disease 3 | 306
Hypertension 3 | 396
Isolated cases 3 | 72
Liver neoplasms 3 | 130
Low set ears 3 | 181
Melanoma 3 | 711
Mental and motor retardation 3 | 608
Multiple Sclerosis 3 | 540
Osteoporosis 3 | 363
Pediatric failure to thrive 3 | 365
Peripheral T-cell lymphoma 3 | 25
Pick disease 3 | 1,894
Polycystic ovary syndrome 3 | 360
Primary cutaneous T-cell lymphoma 3 | 29
Rheumatoid arthritis 3 | 1,191
Urinary Bladder Neoplasms 3 | 114
Vascular disease 3 | 319
active Crohn's disease 3 | 922
acute myeloid leukemia 3 | 783
colon cancer 3 | 1,478
cystic fibrosis 3 | 1,696
dermatomyositis 3 | 966
ductal carcinoma in situ 3 | 1,745
juvenile dermatomyositis 3 | 1,187
nasopharyngeal carcinoma 3 | 1,058
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
posterior fossa group A ependymoma 3 | 468
primary Sjogren syndrome 3 | 735
primary pancreatic ductal adenocarcinoma 3 | 1,109
tuberculosis 3 | 2,010

Tissue

Blood and immune system 30 | 16,909
Digestive Tract 30 | 17,369
Endocrine System 30 | 18,159
Female tissues 30 | 17,400
Liver and Pancreas 30 | 16,750
Male tissues 30 | 17,142
Respiratory system 30 | 16,393
Cardiovascular System 29 | 15,192
Nervous System 29 | 16,725
Skin and soft tissues 29 | 17,230
Urinary Tract 29 | 16,678

Target Family

Transcription Factor 11 | 1,400
Non-IDG 8 | 12,091
Epigenetic 5 | 242
Enzyme 2 | 4,145
Kinase 2 | 634
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

GO Function

activating transcription facto... 30 | 30
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein atonal homolog 8 ATOH8 Tbio Transcription Factor -0.96559 12.3 111
Wolframin WFS1 Tbio Non-IDG -2.40006 260.2 118
Diacylglycerol kinase theta DGKQ Tbio Kinase -1.58632 35.6 169
GA-binding protein alpha chain GABPA Tbio Transcription Factor -1.50283 31.7 289
MHC class II transactivator CIITA Tbio Non-IDG -2.63957 506.8 146
Epidermal retinol dehydrogenase 2 SDR16C5 Tbio Enzyme -0.64412 5.26 106
Transcription initiation factor TFIID subunit 9 TAF9 Tbio Non-IDG -2.18859 223.1 83
Zinc finger protein 516 ZNF516 Tbio Transcription Factor -0.48096 3.21 66
Prothymosin alpha PTMA Tbio Non-IDG -2.46161 279.5 211
PC4 and SFRS1-interacting protein PSIP1 Tbio Epigenetic -2.56190 391.2 150