Development Level

Tbio 75 | 10,625
Tdark 7 | 7,003
Tchem 4 | 1,890
Tclin 3 | 602

Collection

Eligible Ion Channel Proteins 1 | 117

IMPC Term

abnormal behavior 3 | 226
hyperactivity 3 | 108
increased circulating alkaline... 3 | 119
preweaning lethality, complete... 3 | 633
preweaning lethality, incomple... 3 | 260
abnormal bone structure 2 | 131
abnormal embryo size 2 | 112
abnormal placenta size 2 | 10
abnormal retina morphology 2 | 100
absent pinna reflex 2 | 21
corneal opacity 2 | 25
decreased body length 2 | 108
decreased circulating creatini... 2 | 31
decreased lean body mass 2 | 195
embryonic lethality prior to t... 2 | 187
persistence of hyaloid vascula... 2 | 22
abnormal bone mineralization 1 | 55
abnormal coat/hair pigmentatio... 1 | 54
abnormal cornea morphology 1 | 24
abnormal digit morphology 1 | 13
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal glucose homeostasis 1 | 5
abnormal head morphology 1 | 10
abnormal lens morphology 1 | 73
abnormal limb bud morphology 1 | 15
abnormal liver morphology 1 | 5
abnormal locomotor activation 1 | 26
abnormal optic disc morphology 1 | 10
abnormal respiratory quotient 1 | 9
abnormal retinal pigmentation 1 | 61
abnormal skin coloration 1 | 18
abnormal skin morphology 1 | 23
abnormal sleep behavior 1 | 63
abnormal spleen morphology 1 | 36
absent heartbeat 1 | 6
absent teeth 1 | 4
anophthalmia 1 | 20
cardiovascular system phenotyp... 1 | 35
decreased Ly6C low monocyte nu... 1 | 23
decreased NK T cell number 1 | 28
decreased blood urea nitrogen ... 1 | 31
decreased body weight 1 | 174
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating amylase ... 1 | 24
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating glucose ... 1 | 121
decreased circulating glycerol... 1 | 19
decreased circulating insulin ... 1 | 75
decreased circulating iron lev... 1 | 25
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased grip strength 1 | 123
decreased heart rate variabili... 1 | 11
decreased heart weight 1 | 44
decreased leukocyte cell numbe... 1 | 54
decreased lymphocyte cell numb... 1 | 9
decreased monocyte cell number 1 | 28
edema 1 | 11
embryonic lethality prior to o... 1 | 148
enlarged spleen 1 | 26
fused cornea and lens 1 | 4
fused phalanges 1 | 1
hemorrhage 1 | 12
impaired pupillary reflex 1 | 14
impaired righting response 1 | 19
improved glucose tolerance 1 | 56
increased Ly6C high monocyte n... 1 | 12
increased NK T cell number 1 | 11
increased blood urea nitrogen ... 1 | 44
increased circulating chloride... 1 | 43
increased circulating iron lev... 1 | 25
increased circulating phosphat... 1 | 24
increased circulating sodium l... 1 | 71
increased coping response 1 | 3
increased exploration in new e... 1 | 56
increased grip strength 1 | 83
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 93
increased neutrophil cell numb... 1 | 15
increased or absent threshold ... 1 | 128
increased rib number 1 | 41
microphthalmia 1 | 15
pale liver 1 | 5
pale yolk sac 1 | 12
pallor 1 | 13
prenatal lethality prior to he... 1 | 64
small thymus 1 | 11
stereotypic behavior 1 | 3
trunk curl 1 | 15

Disease

ovarian cancer 53 | 8,484
osteosarcoma 48 | 7,933
medulloblastoma, large-cell 43 | 6,234
glioblastoma 41 | 5,572
psoriasis 34 | 6,685
atypical teratoid / rhabdoid tumor 29 | 4,369
lung cancer 28 | 4,466
pilocytic astrocytoma 28 | 3,086
lung carcinoma 27 | 2,844
pediatric high grade glioma 27 | 2,712
intraductal papillary-mucinous neoplasm (IPMN) 26 | 3,289
Carcinoma 25 | 2,147
invasive ductal carcinoma 24 | 2,950
malignant mesothelioma 24 | 3,162
Breast cancer 23 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 23 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,956
lung adenocarcinoma 22 | 2,713
oligodendroglioma 22 | 2,849
pancreatic cancer 22 | 2,300
ependymoma 20 | 2,514
interstitial cystitis 20 | 2,299
non-small cell lung cancer 20 | 2,798
primitive neuroectodermal tumor 20 | 3,031
ulcerative colitis 19 | 2,087
subependymal giant cell astrocytoma 18 | 2,287
astrocytic glioma 17 | 2,241
spina bifida 17 | 1,064
primary pancreatic ductal adenocarcinoma 15 | 1,271
sonic hedgehog group medulloblastoma 15 | 1,482
Duchenne muscular dystrophy 14 | 602
colon cancer 14 | 1,475
ductal carcinoma in situ 14 | 1,745
juvenile dermatomyositis 14 | 1,189
adrenocortical carcinoma 13 | 1,427
tuberculosis 13 | 1,557
adult high grade glioma 12 | 2,148
autosomal dominant Emery-Dreifuss muscular dystrophy 12 | 499
pituitary cancer 12 | 1,972
Pick disease 11 | 1,893
acute quadriplegic myopathy 11 | 1,157
breast carcinoma 11 | 1,614
diabetes mellitus 11 | 1,663
group 3 medulloblastoma 11 | 2,254
Cancer 10 | 2,346
astrocytoma 10 | 1,493
gastric carcinoma 10 | 832
medulloblastoma 10 | 1,524
Rheumatoid Arthritis 9 | 1,160
cystic fibrosis 9 | 1,665
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,795
Alzheimer's disease 8 | 644
Amyotrophic Lateral Sclerosis 8 | 431
cutaneous lupus erythematosus 8 | 1,056
group 4 medulloblastoma 8 | 1,875
posterior fossa group B ependymoma 8 | 1,530
progressive supranuclear palsy 8 | 674
Atopic dermatitis 7 | 944
Down syndrome 7 | 548
acute myeloid leukemia 7 | 780
esophageal adenocarcinoma 7 | 737
posterior fossa group A ependymoma 7 | 1,511
Becker muscular dystrophy 6 | 187
limb girdle muscular dystrophy 2A 6 | 156
non primary Sjogren syndrome sicca 6 | 840
Animal Mammary Neoplasms 5 | 136
Distal arthrogryposis 5 | 45
Nonsyndromic deafness 5 | 121
active Crohn's disease 5 | 918
dermatomyositis 5 | 933
fibroadenoma 5 | 557
hereditary spastic paraplegia 5 | 313
nasopharyngeal carcinoma 5 | 1,056
non-small cell lung carcinoma 5 | 413
pancreatic carcinoma 5 | 567
primary Sjogren syndrome 5 | 789
Bipolar Disorder 4 | 266
Cardiomyopathy 4 | 110
Chronic Lymphocytic Leukemia 4 | 242
Hypertension 4 | 287
IGA Glomerulonephritis 4 | 454
Kidney cancer 4 | 118
Liver cancer 4 | 31
Mammary Neoplasms 4 | 410
Mammary Neoplasms, Experimental 4 | 150
Multiple myeloma 4 | 1,327
Parkinson's disease 4 | 364
Schizophrenia 4 | 501
Sensorineural hearing loss 4 | 107
Waldenstrons macroglobulinemia 4 | 765
Wiskott-Aldrich syndrome 4 | 27
aldosterone-producing adenoma 4 | 664
atypical teratoid/rhabdoid tumor 4 | 1,095
chronic lymphosyte leukemia 4 | 232
mucosa-associated lymphoid tissue lymphoma 4 | 480
sarcoidosis 4 | 358
Endometriosis 3 | 535
Essential Hypertension 3 | 82
hepatocellular carcinoma 3 | 532
urothelial carcinoma 3 | 318

Tissue

Blood and immune system 89 | 17,995
Digestive Tract 89 | 18,473
Female tissues 89 | 18,647
Male tissues 89 | 17,969
Nervous System 89 | 18,561
Cardiovascular System 88 | 17,958
Endocrine System 88 | 18,512
Liver and Pancreas 88 | 18,136
Respiratory system 88 | 17,484
Urinary Tract 88 | 18,444
Skin and soft tissues 85 | 18,115

Target Family

Non-IDG 78 | 11,971
Enzyme 4 | 4,146
Kinase 3 | 634
Ion Channel 2 | 341
Transcription Factor 1 | 1,400
Transporter 1 | 473

GO Function

actin filament binding 89 | 89
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
WD repeat-containing protein 1 WDR1 Tbio Non-IDG -1.58081 43.3 85
Kelch-like protein 17 KLHL17 Tdark Non-IDG -0.22185 2.22 12
Annexin A8 ANXA8L1 Tbio Non-IDG -0.64944 3.98 105
Myosin-3 MYH3 Tbio Non-IDG -1.66510 45.6 38
Spectrin beta chain, erythrocytic SPTB Tbio Non-IDG -2.33882 241.1 36
CLIP-associating protein 2 CLASP2 Tbio Non-IDG -1.22296 20.8 220
GAS2-like protein 2 GAS2L2 Tbio Non-IDG 0.23 0.45 55
Shootin-1 SHTN1 Tbio Non-IDG -0.97772 9.81 24
Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 Tchem Ion Channel -1.43080 25.0 426
Nebulette NEBL Tbio Non-IDG -1.40484 29.2 48