Development Level

Tbio 103 | 10,625
Tdark 16 | 7,003
Tchem 8 | 1,890
Tclin 6 | 602

IMPC Phenotype

preweaning lethality, complete... 10 | 633
preweaning lethality, incomple... 6 | 260
decreased body weight 4 | 174
decreased circulating HDL chol... 4 | 77
increased circulating alkaline... 4 | 119
abnormal bone structure 3 | 131
abnormal embryo size 3 | 112
decreased bone mineral content 3 | 157
decreased circulating choleste... 3 | 85
decreased total body fat amoun... 3 | 186
increased body weight 3 | 42
abnormal behavior 2 | 226
abnormal sleep behavior 2 | 63
decreased circulating LDL chol... 2 | 37
decreased circulating alanine ... 2 | 53
decreased circulating fructosa... 2 | 31
decreased circulating glucose ... 2 | 121
decreased circulating serum al... 2 | 79
decreased circulating total pr... 2 | 41
decreased circulating triglyce... 2 | 83
decreased grip strength 2 | 123
decreased lean body mass 2 | 195
hemorrhage 2 | 12
increased heart weight 2 | 37
increased lean body mass 2 | 107
increased or absent threshold ... 2 | 128
increased total body fat amoun... 2 | 57
prenatal lethality prior to he... 2 | 64
abnormal bone mineralization 1 | 55
abnormal coat appearance 1 | 25
abnormal coat-hair pigmentatio... 1 | 54
abnormal craniofacial morpholo... 1 | 12
abnormal digestive system phys... 1 | 1
abnormal forebrain morphology 1 | 4
abnormal lens morphology 1 | 73
abnormal locomotor activation 1 | 26
abnormal neural tube closure 1 | 37
abnormal placenta size 1 | 10
abnormal posture 1 | 5
abnormal respiratory quotient 1 | 9
abnormal retina morphology 1 | 100
abnormal retinal blood vessel ... 1 | 18
abnormal retinal pigmentation 1 | 61
abnormal skin coloration 1 | 18
abnormal tail morphology 1 | 17
abnormal vertebrae morphology 1 | 14
cataract 1 | 26
cyanosis 1 | 6
decreased NK T cell number 1 | 28
decreased body length 1 | 108
decreased bone mineral density 1 | 126
decreased circulating aspartat... 1 | 27
decreased circulating calcium ... 1 | 33
decreased circulating chloride... 1 | 32
decreased circulating creatini... 1 | 31
decreased circulating iron lev... 1 | 25
decreased circulating potassiu... 1 | 17
decreased fasted circulating g... 1 | 49
decreased lactate dehydrogenas... 1 | 14
decreased leukocyte cell numbe... 1 | 54
decreased lumbar vertebrae num... 1 | 62
decreased lymphocyte cell numb... 1 | 9
decreased mean corpuscular hem... 1 | 19
decreased mean corpuscular vol... 1 | 50
decreased mean platelet volume 1 | 12
decreased rib number 1 | 59
decreased spleen weight 1 | 13
decreased thermal nociceptive ... 1 | 4
decreased total retina thickne... 1 | 20
edema 1 | 11
embryonic lethality prior to t... 1 | 187
enlarged heart 1 | 111
eye hemorrhage 1 | 1
female infertility 1 | 34
fused cornea and lens 1 | 4
hyperactivity 1 | 108
immune system phenotype 1 | 17
impaired pupillary reflex 1 | 14
improved glucose tolerance 1 | 56
increased CD4-positive NK T ce... 1 | 3
increased NK T cell number 1 | 11
increased circulating alanine ... 1 | 11
increased circulating amylase ... 1 | 13
increased circulating calcium ... 1 | 32
increased circulating chloride... 1 | 43
increased circulating creatini... 1 | 29
increased circulating free fat... 1 | 17
increased circulating phosphat... 1 | 24
increased circulating serum al... 1 | 25
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 20
increased memory-marker CD4-po... 1 | 3
increased neutrophil cell numb... 1 | 15
increased red blood cell distr... 1 | 21
increased vertical activity 1 | 18
mydriasis 1 | 9
oligodactyly 1 | 14
short tibia 1 | 82
vertebral fusion 1 | 23

Disease

ovarian cancer 75 | 8,491
osteosarcoma 63 | 7,933
glioblastoma 62 | 5,572
psoriasis 61 | 6,685
medulloblastoma, large-cell 56 | 6,234
lung cancer 47 | 4,473
atypical teratoid / rhabdoid tumor 46 | 4,369
pilocytic astrocytoma 45 | 3,086
intraductal papillary-mucinous neoplasm (IPMN) 44 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 39 | 2,988
malignant mesothelioma 39 | 3,163
intraductal papillary-mucinous adenoma (IPMA) 38 | 2,956
pancreatic cancer 37 | 2,300
pediatric high grade glioma 36 | 2,712
primitive neuroectodermal tumor 36 | 3,031
Breast cancer 35 | 3,098
invasive ductal carcinoma 35 | 2,950
Carcinoma 34 | 2,147
non-small cell lung cancer 33 | 2,798
lung carcinoma 31 | 2,844
oligodendroglioma 31 | 2,849
lung adenocarcinoma 30 | 2,714
ependymoma 29 | 2,514
subependymal giant cell astrocytoma 29 | 2,287
ductal carcinoma in situ 28 | 1,745
interstitial cystitis 27 | 2,299
astrocytoma 23 | 1,493
colon cancer 23 | 1,475
Cancer 22 | 2,346
astrocytic glioma 22 | 2,241
primary pancreatic ductal adenocarcinoma 22 | 1,271
ulcerative colitis 22 | 2,087
tuberculosis 21 | 1,563
Pick disease 19 | 1,893
acute quadriplegic myopathy 19 | 1,157
cystic fibrosis 19 | 1,670
group 4 medulloblastoma 19 | 1,875
breast carcinoma 18 | 1,614
Duchenne muscular dystrophy 17 | 602
medulloblastoma 17 | 1,524
pancreatic ductal adenocarcinoma liver metastasis 17 | 1,795
pituitary cancer 17 | 1,972
sonic hedgehog group medulloblastoma 17 | 1,482
adrenocortical carcinoma 16 | 1,427
dermatomyositis 16 | 966
juvenile dermatomyositis 16 | 1,189
nasopharyngeal carcinoma 16 | 1,056
Rheumatoid Arthritis 15 | 1,170
adult high grade glioma 15 | 2,148
spina bifida 15 | 1,064
diabetes mellitus 14 | 1,663
primary Sjogren syndrome 14 | 788
Atopic dermatitis 13 | 944
cutaneous lupus erythematosus 13 | 1,056
posterior fossa group B ependymoma 13 | 1,530
Down syndrome 12 | 548
autosomal dominant Emery-Dreifuss muscular dystrophy 12 | 499
posterior fossa group A ependymoma 12 | 1,511
Cardiomyopathy 11 | 110
active ulcerative colitis 11 | 477
esophageal adenocarcinoma 11 | 737
group 3 medulloblastoma 11 | 2,254
progressive supranuclear palsy 11 | 674
active Crohn's disease 10 | 918
atypical teratoid/rhabdoid tumor 10 | 1,095
Amyotrophic Lateral Sclerosis 9 | 432
Waldenstrons macroglobulinemia 9 | 764
fibroadenoma 9 | 557
gastric carcinoma 9 | 832
Alzheimer's disease 8 | 644
Multiple myeloma 8 | 1,327
Neurodegenerative disease 8 | 383
Osteoporosis 8 | 259
chronic rhinosinusitis 8 | 512
hereditary spastic paraplegia 8 | 313
mucosa-associated lymphoid tissue lymphoma 8 | 480
Becker muscular dystrophy 7 | 187
Cardiomyopathies 7 | 90
Hypertension 7 | 293
IGA Glomerulonephritis 7 | 454
Kidney disease 7 | 397
aldosterone-producing adenoma 7 | 664
hepatocellular carcinoma 7 | 550
sarcoidosis 7 | 368
tuberculosis and treatment for 6 months 7 | 686
Crohn's disease 6 | 304
Endometriosis 6 | 535
Intellectual disability 6 | 573
Multiple Sclerosis 6 | 498
Polycystic Ovary Syndrome 6 | 334
Renal Cell Carcinoma 6 | 199
acute myeloid leukemia 6 | 785
Dementia 5 | 129
Dilated cardiomyopathy 5 | 51
Hypertensive disease 5 | 193
Neuropathy 5 | 210
Parkinson's disease 5 | 364
Prostatic Neoplasms 5 | 471
cystic fibrosis and chronic rhinosinusitis 5 | 213
pancreatic carcinoma 5 | 567

Tissue

Cardiovascular System 133 | 17,957
Digestive Tract 133 | 18,472
Endocrine System 133 | 18,511
Female tissues 133 | 18,646
Liver and Pancreas 133 | 18,135
Male tissues 133 | 17,968
Nervous System 133 | 18,560
Skin and soft tissues 133 | 18,114
Urinary Tract 133 | 18,443
Blood and immune system 132 | 17,994
Respiratory system 132 | 17,483

Target Family

Non-IDG 101 | 11,969
Enzyme 25 | 4,146
Ion Channel 3 | 341
GPCR 2 | 408
Kinase 2 | 634

GO Function

actin binding 133 | 133
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine-threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
RNA polymerase II regulatory r... 200 | 200
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Actin-binding protein IPP IPP Tdark Non-IDG -2.89711 782.9 29
WAS/WASL-interacting protein family member 1 WIPF1 Tbio Non-IDG -2.00605 100.9 97
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 MACF1 Tbio Non-IDG -2.00226 100.4 30
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 ALKBH4 Tdark Enzyme -0.33099 3.01 78
Calcium-activated potassium channel subunit alpha-1 KCNMA1 Tclin Ion Channel -3.08349 1170.6 213
Protein phosphatase Slingshot homolog 1 SSH1 Tbio Enzyme -1.42592 25.0 106
Wiskott-Aldrich syndrome protein family member 2 WASF2 Tbio Non-IDG -2.86162 683.7 211
Smoothelin SMTN Tbio Non-IDG -2.03134 104.5 72
Spectrin alpha chain, non-erythrocytic 1 SPTAN1 Tbio Non-IDG -2.41058 258.0 266
Kelch-like protein 33 KLHL33 Tdark Non-IDG 1.08 0.08 19