Development Level

Tbio 221 | 11,651
Tdark 31 | 6,593
Tchem 13 | 1,388
Tclin 7 | 612

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 26 | 979
preweaning lethality, incomple... 18 | 499
abnormal embryo size 10 | 220
decreased body weight 9 | 161
embryonic lethality prior to t... 9 | 278
abnormal behavior 7 | 298
decreased total body fat amoun... 7 | 207
abnormal bone structure 6 | 187
hyperactivity 6 | 148
abnormal sleep behavior 5 | 70
decreased circulating choleste... 5 | 93
decreased grip strength 5 | 116
decreased vertical activity 5 | 208
embryonic growth retardation 5 | 106
increased circulating alkaline... 5 | 122
decreased circulating total pr... 4 | 49
decreased circulating triglyce... 4 | 79
prolonged ST segment 4 | 36
abnormal behavioral response t... 3 | 66
abnormal coat-hair pigmentatio... 3 | 64
abnormal seminal vesicle morph... 3 | 114
decreased blood urea nitrogen ... 3 | 51
decreased body length 3 | 101
decreased bone mineral density 3 | 126
decreased circulating HDL chol... 3 | 68
decreased circulating amylase ... 3 | 28
decreased circulating fructosa... 3 | 30
decreased circulating glucose ... 3 | 126
decreased circulating serum al... 3 | 82
decreased lean body mass 3 | 135
decreased lymphocyte cell numb... 3 | 83
decreased mean corpuscular vol... 3 | 79
embryonic lethality prior to o... 3 | 239
hypoactivity 3 | 132
increased circulating sodium l... 3 | 71
increased lean body mass 3 | 172
increased vertical activity 3 | 24
prenatal lethality prior to he... 3 | 87
abnormal bone mineralization 2 | 38
abnormal coat appearance 2 | 31
abnormal craniofacial morpholo... 2 | 33
abnormal embryo turning 2 | 31
abnormal pericardium morpholog... 2 | 26
abnormal retina morphology 2 | 71
abnormal skin coloration 2 | 25
abnormal tail morphology 2 | 25
abnormal vertebrae morphology 2 | 18
decreased bone mineral content 2 | 151
decreased caudal vertebrae num... 2 | 53
decreased circulating LDL chol... 2 | 38
decreased circulating alanine ... 2 | 47
decreased circulating insulin ... 2 | 76
decreased circulating iron lev... 2 | 32
decreased erythrocyte cell num... 2 | 62
decreased hemoglobin content 2 | 68
decreased leukocyte cell numbe... 2 | 73
decreased startle reflex 2 | 75
enlarged heart 2 | 210
hemorrhage 2 | 23
improved glucose tolerance 2 | 79
increased body length 2 | 32
increased body weight 2 | 25
increased circulating chloride... 2 | 41
increased circulating iron lev... 2 | 30
increased fasted circulating g... 2 | 76
increased heart weight 2 | 62
increased mean corpuscular hem... 2 | 36
increased or absent threshold ... 2 | 101
increased red blood cell distr... 2 | 34
pallor 2 | 34
prolonged QT interval 2 | 38
vertebral fusion 2 | 23
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal neural tube closure 1 | 46
abnormal retinal inner nuclear... 1 | 8
abnormal spleen morphology 1 | 55
abnormal vocalization 1 | 21
abnormal whole-body plethysmog... 1 | 4
convulsive seizures 1 | 13
decreased T cell number 1 | 15
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating potassiu... 1 | 20
decreased fluid intake 1 | 3
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
decreased total retina thickne... 1 | 17
impaired pupillary reflex 1 | 26
increased bone mineral density 1 | 72
increased circulating amylase ... 1 | 25
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased circulating triglyce... 1 | 42
increased mean corpuscular vol... 1 | 92
increased startle reflex 1 | 112
long tibia 1 | 25
thin ventricular wall 1 | 24
tremors 1 | 39

Disease

Carcinoma 206 | 11,493
ovarian cancer 151 | 8,520
osteosarcoma 142 | 7,950
glioblastoma 127 | 5,792
psoriasis 122 | 6,694
medulloblastoma, large-cell 120 | 6,241
atypical teratoid / rhabdoid tumor 112 | 5,112
ependymoma 98 | 4,679
lung cancer 93 | 4,740
Breast cancer 88 | 3,578
Astrocytoma, Pilocytic 83 | 3,081
adult high grade glioma 82 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 76 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 76 | 2,989
primitive neuroectodermal tumor 76 | 3,035
group 3 medulloblastoma 75 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 75 | 3,291
invasive ductal carcinoma 72 | 2,951
pancreatic cancer 72 | 2,398
non-small cell lung cancer 71 | 2,890
malignant mesothelioma 70 | 3,232
Kidney cancer 68 | 2,613
lung carcinoma 67 | 2,843
subependymal giant cell astrocytoma 63 | 2,287
oligodendroglioma 62 | 2,850
lung adenocarcinoma 61 | 2,716
astrocytic glioma 54 | 2,597
ductal carcinoma in situ 50 | 1,745
interstitial cystitis 48 | 2,312
breast carcinoma 44 | 1,638
colon cancer 44 | 1,478
pancreatic ductal adenocarcinoma liver metastasis 42 | 1,962
tuberculosis 42 | 2,010
Pick disease 41 | 1,894
acute quadriplegic myopathy 41 | 1,158
cystic fibrosis 41 | 1,696
ulcerative colitis 38 | 1,819
Cancer 37 | 2,499
adrenocortical carcinoma 37 | 1,428
juvenile dermatomyositis 37 | 1,187
Duchenne muscular dystrophy 35 | 601
group 4 medulloblastoma 35 | 1,855
primary pancreatic ductal adenocarcinoma 35 | 1,109
Rheumatoid arthritis 32 | 1,191
spina bifida 32 | 1,074
astrocytoma 31 | 1,146
pituitary cancer 31 | 1,972
diabetes mellitus 30 | 1,728
Autosomal recessive predisposition 27 | 1,442
Liver cancer 27 | 604
Schizophrenia 27 | 1,160
cutaneous lupus erythematosus 27 | 1,057
dermatomyositis 25 | 966
Down syndrome 24 | 499
autosomal dominant Emery-Dreifuss muscular dystrophy 24 | 510
gastric carcinoma 24 | 807
nasopharyngeal carcinoma 24 | 1,058
Liver Cirrhosis, Experimental 23 | 769
Waldenstrons macroglobulinemia 23 | 765
pediatric high grade glioma 23 | 1,064
primary Sjogren syndrome 23 | 735
esophageal adenocarcinoma 20 | 737
progressive supranuclear palsy 20 | 676
Atopic dermatitis 19 | 952
active Crohn's disease 19 | 922
aldosterone-producing adenoma 19 | 665
Multiple myeloma 18 | 1,332
active ulcerative colitis 18 | 764
fibroadenoma 18 | 559
Amyotrophic lateral sclerosis 17 | 451
Melanoma 17 | 711
medulloblastoma 17 | 720
Bipolar Disorder 16 | 666
hereditary spastic paraplegia 16 | 318
Neurodegenerative disease 14 | 414
Intellectual disability 13 | 1,016
Skin cancer 13 | 469
Alzheimer's disease 12 | 658
Cardiomyopathy 12 | 116
Endometriosis 12 | 540
Hypertension 12 | 396
Nonsyndromic deafness 12 | 142
Parkinson's disease 12 | 392
Wiskott-Aldrich syndrome 12 | 30
acute myeloid leukemia 12 | 783
mucosa-associated lymphoid tissue lymphoma 12 | 484
pancreatic carcinoma 12 | 562
Endometrial cancer 11 | 311
Neuropathy 11 | 261
chronic rhinosinusitis 11 | 512
gastric cancer 11 | 459
Becker muscular dystrophy 10 | 191
Kidney disease 10 | 430
Multiple Sclerosis 10 | 540
hepatocellular carcinoma 10 | 547
Cardiomyopathy, Dilated 9 | 83
Epilepsy 9 | 792
Polycystic ovary syndrome 9 | 360
Substance-Related Disorders 9 | 115
sonic hedgehog group medulloblastoma 9 | 467

Tissue

Endocrine System 266 | 18,159
Male tissues 263 | 17,142
Skin and soft tissues 262 | 17,230
Urinary Tract 262 | 16,678
Digestive Tract 260 | 17,369
Female tissues 259 | 17,400
Liver and Pancreas 258 | 16,750
Blood and immune system 257 | 16,909
Nervous System 255 | 16,725
Respiratory system 251 | 16,393
Cardiovascular System 245 | 15,192

Target Family

Non-IDG 220 | 12,091
Enzyme 35 | 4,145
Kinase 8 | 634
Ion Channel 6 | 344
GPCR 2 | 408
Epigenetic 1 | 242

GO Function

actin binding 272 | 272
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Actin filament-associated protein 1 AFAP1 Tbio Non-IDG -1.89567 70.0 314
Phosphatase and actin regulator 1 PHACTR1 Tbio Enzyme -1.79171 63.2 41
F-actin-capping protein subunit alpha-3 CAPZA3 Tdark Non-IDG -0.56455 3.20 78
Myosin light chain kinase, smooth muscle MYLK Tchem Kinase -2.81312 694.0 219
Unconventional myosin-VIIb MYO7B Tbio Non-IDG -0.65885 5.07 14
Spectrin beta chain, non-erythrocytic 5 SPTBN5 Tbio Non-IDG -0.41365 2.99 32
Germinal center-associated signaling and motility protein GCSAM Tbio Non-IDG -1.48861 37.8 109
Formin-like protein 2 FMNL2 Tbio Non-IDG -1.22907 18.1 74
Drebrin-like protein DBNL Tbio Non-IDG -1.16567 21.1 172
Melanophilin MLPH Tbio Non-IDG -1.57425 39.8 142