Development Level

Tclin 9 | 613
Tchem 4 | 1,598

Collection

Ion Channel: IDG Consortium (T... 3 | 99

IMPC Phenotype

abnormal epididymis morphology 1 | 42
abnormal joint morphology 1 | 23
brachydactyly 1 | 19
enlarged heart 1 | 210
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499
syndactyly 1 | 23

Disease

Carcinoma 11 | 11,493
Nicotine dependence 10 | 54
Seizures 6 | 596
psoriasis 6 | 6,694
Epilepsy 5 | 792
Frontal lobe epilepsy 5 | 10
Schizophrenia 5 | 1,160
Smoking cessation assistance 5 | 8
Alcohol dependence 4 | 107
Alcoholic Intoxication, Chronic 4 | 289
Alzheimer's disease 4 | 658
Autosomal recessive predisposition 4 | 1,442
Bipolar Disorder 4 | 666
Congenital myasthenic syndrome 4 | 25
General anesthesia 4 | 53
Muscle relaxation, function 4 | 8
Neuropathy 4 | 261
Niacin deficiency 4 | 5
Nicotine Withdrawal Symptoms 4 | 5
Pellagra 4 | 26
ependymoma 4 | 4,679
osteosarcoma 4 | 7,950
Astrocytoma, Pilocytic 3 | 3,081
Attention deficit hyperactivity disorder 3 | 278
Autistic Disorder 3 | 364
Autosomal dominant nocturnal frontal lobe epilepsy 3 | 4
Bell Palsy 3 | 58
Blepharoptosis 3 | 231
Byzanthine arch palate 3 | 194
Cocaine Dependence 3 | 51
Congenital Myasthenic Syndromes, Postsynaptic 3 | 11
Dementia 3 | 175
Depressive disorder 3 | 409
Easy fatigability 3 | 18
Facial Paresis 3 | 59
Facial muscle weakness of muscles innervated by CN VII 3 | 58
Feeding difficulties 3 | 127
Hypertensive disorder 3 | 56
Lung Neoplasms 3 | 232
Mental Depression 3 | 333
Multiple pterygium syndrome 3 | 18
Myasthenic Syndrome, Congenital, 1A, Slow-Channel 3 | 4
Myasthenic Syndromes, Congenital 3 | 16
Myasthenic syndrome, congenital, postsynaptic slow-channel 3 | 4
Neonatal Hypotonia 3 | 64
Ophthalmoplegia 3 | 106
Parkinson's disease 3 | 392
Skeletal Muscle Relaxation for Endotracheal Intubation 3 | 5
Skeletal Muscle Relaxation for Endotracheal Intubation in C-Section 3 | 5
TOBACCO ADDICTION, SUSCEPTIBILITY TO 3 | 12
TOBACCO ADDICTION, SUSCEPTIBILITY TO (finding) 3 | 12
Tires quickly 3 | 18
adult high grade glioma 3 | 3,801
glioblastoma 3 | 5,792
lung cancer 3 | 4,740
lung carcinoma 3 | 2,843
substance-related disorder 3 | 162
Abnormal behavior 2 | 52
Akinesia 2 | 13
Alzheimer Disease 2 | 83
Attention Deficit Disorder with Hyperactivity 2 | 21
Congenital Epicanthus 2 | 177
Congenital anomaly of face 2 | 56
Constipation 2 | 181
Contracture 2 | 96
Contracture of joint 2 | 93
Cystic lymphangioma 2 | 19
Deglutition Disorders 2 | 132
Distortion of face 2 | 46
Dysmorphic facies 2 | 46
Early severe fetal akinesia sequence 2 | 11
Flexion contracture 2 | 93
Flexion contractures of joints 2 | 93
Funny looking face 2 | 46
Fused vertebrae 2 | 25
Generalized muscle weakness 2 | 57
Increased susceptibility to fractures 2 | 21
Infantile onset 2 | 238
Inflammation 2 | 120
Lymphangioma, Cystic 2 | 21
MULTIPLE PTERYGIUM SYNDROME, LETHAL TYPE 2 | 5
Myasthenic Syndrome, Congenital, with Facial Dysmorphism, associated with Acetylcholine Receptor Deficiency 2 | 4
Neck muscle weakness 2 | 17
Nervous System Diseases 2 | 53
Open-angle glaucoma 2 | 27
Pain agnosia 2 | 104
Pena-Shokeir syndrome type I 2 | 12
Polyhydramnios 2 | 108
Prenatal onset 2 | 139
Pulmonary edema 2 | 17
Respiratory Insufficiency 2 | 132
Respiratory function loss 2 | 121
Spinal fusion 2 | 25
Substance Withdrawal Syndrome 2 | 55
Sudden infant death syndrome 2 | 32
Thin rib 2 | 21
Toxic encephalopathy 2 | 141
Vertebral body fusion 2 | 25
facial deformity 2 | 46
nervous system disorder 2 | 53

Tissue

Endocrine System 12 | 18,159
Digestive Tract 11 | 17,369
Female tissues 11 | 17,400
Liver and Pancreas 11 | 16,750
Nervous System 11 | 16,725
Skin and soft tissues 11 | 17,230
Blood and immune system 10 | 16,909
Male tissues 10 | 17,142
Urinary Tract 9 | 16,678
Respiratory system 8 | 16,393
Cardiovascular System 6 | 15,192

Target Family

Ion Channel 10 | 344
Enzyme 1 | 4,145
GPCR 1 | 408
Transporter 1 | 473

GO Function

acetylcholine binding 13 | 13
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Neuronal acetylcholine receptor subunit beta-2 CHRNB2 Tclin Ion Channel -1.62448 37.6 174
Acetylcholine receptor subunit alpha CHRNA1 Tclin Ion Channel -1.66400 41.7 307
Neuronal acetylcholine receptor subunit alpha-7 CHRFAM7A Tchem Ion Channel -1.81173 87.7 226
Acetylcholinesterase ACHE Tclin Enzyme -3.49768 2470.5 505
Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 Tchem Ion Channel -1.31722 18.3 117
Neuronal acetylcholine receptor subunit beta-4 CHRNB4 Tclin Ion Channel -1.57182 33.7 130
Acetylcholine receptor subunit delta CHRND Tclin Ion Channel -1.30154 18.9 155
Acetylcholine receptor subunit beta CHRNB1 Tclin Ion Channel -1.26222 17.9 180
Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 Tclin Ion Channel -3.62589 4263.7 202
Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 Tclin Ion Channel -1.99577 92.1 193