Development Level

Tbio 28 | 11,445
Tchem 2 | 1,598
Tclin 1 | 613

Collection

GPCR: IDG Consortium (Targets) 1 | 126
RFA-RM-18-021 1 | 328

IMPC Phenotype

embryonic lethality prior to t... 3 | 278
preweaning lethality, complete... 3 | 979
decreased body weight 2 | 161
decreased vertical activity 2 | 208
embryonic lethality prior to o... 2 | 239
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal embryo development 1 | 7
abnormal embryo turning 1 | 31
abnormal eye morphology 1 | 68
abnormal eye size 1 | 7
abnormal heart morphology 1 | 162
abnormal iris morphology 1 | 13
abnormal pericardium morpholog... 1 | 26
abnormal tail movements 1 | 12
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased lean body mass 1 | 135
decreased startle reflex 1 | 75
enlarged heart 1 | 210
hydrometra 1 | 53
hydrops fetalis 1 | 1
impaired glucose tolerance 1 | 75
increased circulating glucose ... 1 | 24
increased circulating insulin ... 1 | 3
increased heart rate variabili... 1 | 7
increased startle reflex 1 | 112
kinked tail 1 | 2
mammalian phenotype 1 | 17
microphthalmia 1 | 26
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
small superior vagus ganglion 1 | 74

Disease

Carcinoma 26 | 11,493
ependymoma 19 | 4,679
atypical teratoid / rhabdoid tumor 18 | 5,112
ovarian cancer 18 | 8,520
Breast cancer 17 | 3,578
osteosarcoma 17 | 7,950
psoriasis 17 | 6,694
glioblastoma 16 | 5,792
interstitial cystitis 15 | 2,312
medulloblastoma, large-cell 15 | 6,241
group 3 medulloblastoma 14 | 4,104
lung cancer 13 | 4,740
Cancer 12 | 2,499
Astrocytoma, Pilocytic 11 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
non-small cell lung cancer 10 | 2,890
primitive neuroectodermal tumor 10 | 3,035
astrocytic glioma 9 | 2,597
breast carcinoma 9 | 1,638
cystic fibrosis 9 | 1,696
invasive ductal carcinoma 9 | 2,951
lung adenocarcinoma 9 | 2,716
pituitary cancer 9 | 1,972
Kidney cancer 8 | 2,613
ductal carcinoma in situ 8 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
oligodendroglioma 8 | 2,850
primary pancreatic ductal adenocarcinoma 8 | 1,109
Autosomal recessive predisposition 7 | 1,442
malignant mesothelioma 7 | 3,232
pancreatic cancer 7 | 2,398
subependymal giant cell astrocytoma 7 | 2,287
cutaneous lupus erythematosus 6 | 1,057
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
lung carcinoma 6 | 2,843
Breast Neoplasms 5 | 445
Colorectal Neoplasms 5 | 243
Duchenne muscular dystrophy 5 | 601
Orbital separation excessive 5 | 244
Pick disease 5 | 1,894
Syndactyly 5 | 88
acute myeloid leukemia 5 | 783
adult high grade glioma 5 | 3,801
colon cancer 5 | 1,478
medulloblastoma 5 | 720
pediatric high grade glioma 5 | 1,064
ulcerative colitis 5 | 1,819
Liver Cirrhosis, Experimental 4 | 769
Mammary Neoplasms 4 | 425
Osteoporosis 4 | 363
active Crohn's disease 4 | 922
adrenocortical carcinoma 4 | 1,428
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
gastric carcinoma 4 | 807
limb girdle muscular dystrophy 2A 4 | 213
Atopic dermatitis 3 | 952
Big calvaria 3 | 147
Bipolar Disorder 3 | 666
Class III malocclusion 3 | 78
Cleft Palate 3 | 271
Exudative vitreoretinopathy 3 | 15
Frontal bossing 3 | 157
Hypertrophy of lower jaw 3 | 78
Hypoplastic mandible condyle 3 | 275
Increased head circumference 3 | 147
Increased size of cranium 3 | 147
Increased size of mandible 3 | 78
Increased size of skull 3 | 147
Mandibular hyperplasia 3 | 78
Mandibular hypoplasia 3 | 275
Micrognathism 3 | 275
Obesity 3 | 678
Robinow syndrome 3 | 11
acute quadriplegic myopathy 3 | 1,158
diabetes mellitus 3 | 1,728
juvenile dermatomyositis 3 | 1,187
mandibular excess (physical finding) 3 | 78
nasopharyngeal carcinoma 3 | 1,058
osteoporosis-pseudoglioma syndrome 3 | 9
posterior fossa group A ependymoma 3 | 468
tuberculosis 3 | 2,010
Acquired scoliosis 2 | 281
Adenoma 2 | 167
Concave bridge of nose 2 | 195
Craniosynostosis 2 | 74
Curvature of spine 2 | 282
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Infantile onset 2 | 238
Kidney disease 2 | 430
Long philtrum 2 | 137
Melanoma 2 | 711
Short nose 2 | 132
Skin cancer 2 | 469
Small nose 2 | 132
Ventricular Septal Defects 2 | 119
active ulcerative colitis 2 | 764
glioblastoma multiforme 2 | 142
head and neck cancer 2 | 271
type II diabetes mellitus and post-ischemic heart failure 2 | 88

Tissue

Blood and immune system 31 | 16,909
Digestive Tract 31 | 17,369
Endocrine System 31 | 18,159
Female tissues 31 | 17,400
Male tissues 31 | 17,142
Nervous System 31 | 16,725
Skin and soft tissues 31 | 17,230
Cardiovascular System 30 | 15,192
Respiratory system 30 | 16,393
Urinary Tract 30 | 16,678
Liver and Pancreas 29 | 16,750

Target Family

Non-IDG 13 | 12,091
GPCR 11 | 408
Enzyme 4 | 4,145
Kinase 3 | 634

GO Function

Wnt-protein binding 31 | 31
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Metalloprotease TIKI2 TRABD2B Tbio Enzyme -0.77815 7.28 4
Smoothened homolog SMO Tclin GPCR -1.17466 14.5 415
Metalloprotease TIKI1 TRABD2A Tbio Enzyme -0.46489 2.81 55
Inactive tyrosine-protein kinase transmembrane receptor ROR1 ROR1 Tbio Kinase -1.38904 30.7 332
Low-density lipoprotein receptor-related protein 5 LRP5 Tbio Non-IDG -3.10429 1247.5 302
Frizzled-7 FZD7 Tbio GPCR -1.81873 66.4 345
Frizzled-8 FZD8 Tbio GPCR -1.64874 42.5 233
Protein-serine O-palmitoleoyltransferase porcupine PORCN Tchem Enzyme -2.18879 156.2 58
Secreted frizzled-related protein 3 FRZB Tbio Non-IDG -2.51623 308.4 252
Frizzled-9 FZD9 Tbio GPCR -1.77240 61.8 380