Development Level

Tbio 20 | 11,445
Tchem 1 | 1,598

Collection

GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

decreased body weight 2 | 161
decreased vertical activity 2 | 208
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
preweaning lethality, complete... 2 | 979
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal eye morphology 1 | 68
abnormal eye size 1 | 7
abnormal heart morphology 1 | 162
abnormal iris morphology 1 | 13
abnormal tail movements 1 | 12
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased lean body mass 1 | 135
decreased startle reflex 1 | 75
enlarged heart 1 | 210
hydrometra 1 | 53
hydrops fetalis 1 | 1
impaired glucose tolerance 1 | 75
increased circulating glucose ... 1 | 24
increased circulating insulin ... 1 | 3
increased startle reflex 1 | 112
kinked tail 1 | 2
mammalian phenotype 1 | 17
microphthalmia 1 | 26
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
small superior vagus ganglion 1 | 74

Disease

Carcinoma 17 | 11,493
atypical teratoid / rhabdoid tumor 14 | 5,112
psoriasis 14 | 6,694
Breast cancer 13 | 3,578
ependymoma 13 | 4,679
ovarian cancer 13 | 8,520
osteosarcoma 12 | 7,950
glioblastoma 11 | 5,792
interstitial cystitis 11 | 2,312
Cancer 10 | 2,499
group 3 medulloblastoma 10 | 4,104
medulloblastoma, large-cell 10 | 6,241
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
lung cancer 9 | 4,740
primitive neuroectodermal tumor 8 | 3,035
Astrocytoma, Pilocytic 7 | 3,081
non-small cell lung cancer 7 | 2,890
Kidney cancer 6 | 2,613
cystic fibrosis 6 | 1,696
ductal carcinoma in situ 6 | 1,745
lung adenocarcinoma 6 | 2,716
pituitary cancer 6 | 1,972
Autosomal recessive predisposition 5 | 1,442
Breast Neoplasms 5 | 445
astrocytic glioma 5 | 2,597
breast carcinoma 5 | 1,638
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
invasive ductal carcinoma 5 | 2,951
lung carcinoma 5 | 2,843
malignant mesothelioma 5 | 3,232
oligodendroglioma 5 | 2,850
pancreatic cancer 5 | 2,398
pediatric high grade glioma 5 | 1,064
primary pancreatic ductal adenocarcinoma 5 | 1,109
subependymal giant cell astrocytoma 5 | 2,287
Colorectal Neoplasms 4 | 243
Mammary Neoplasms 4 | 425
Pick disease 4 | 1,894
acute myeloid leukemia 4 | 783
colon cancer 4 | 1,478
Bipolar Disorder 3 | 666
Class III malocclusion 3 | 78
Cleft Palate 3 | 271
Duchenne muscular dystrophy 3 | 601
Exudative vitreoretinopathy 3 | 15
Hypertrophy of lower jaw 3 | 78
Increased size of mandible 3 | 78
Mandibular hyperplasia 3 | 78
Orbital separation excessive 3 | 244
Osteoporosis 3 | 363
active Crohn's disease 3 | 922
adrenocortical carcinoma 3 | 1,428
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
cutaneous lupus erythematosus 3 | 1,057
diabetes mellitus 3 | 1,728
gastric carcinoma 3 | 807
limb girdle muscular dystrophy 2A 3 | 213
mandibular excess (physical finding) 3 | 78
medulloblastoma 3 | 720
osteoporosis-pseudoglioma syndrome 3 | 9
posterior fossa group A ependymoma 3 | 468
Adenoma 2 | 167
Bell Palsy 2 | 58
Big calvaria 2 | 147
Blind Vision 2 | 111
Blindness, Legal 2 | 110
Craniofacial Abnormalities 2 | 151
Dental caries 2 | 164
Down syndrome 2 | 499
Facial Paresis 2 | 59
Facial muscle weakness of muscles innervated by CN VII 2 | 58
Frequent fractures 2 | 53
Frontal bossing 2 | 157
Increased fracture rate 2 | 53
Increased head circumference 2 | 147
Increased size of cranium 2 | 147
Increased size of skull 2 | 147
Infantile onset 2 | 238
Liver Cirrhosis, Experimental 2 | 769
Neoplasm Metastasis 2 | 168
Pigmentary retinal degeneration 2 | 11
Retinal Detachment 2 | 51
Retinal Neovascularization 2 | 4
Retinal exudates 2 | 11
Sensorineural Hearing Loss (disorder) 2 | 284
Slow progression 2 | 89
Varying degree of multiple fractures 2 | 53
Vascular disease 2 | 319
active ulcerative colitis 2 | 764
acute quadriplegic myopathy 2 | 1,158
adult high grade glioma 2 | 3,801
aldosterone-producing adenoma 2 | 665
esophageal adenocarcinoma 2 | 737
fibroadenoma 2 | 559
glioblastoma multiforme 2 | 142
interstitial lung disease 2 | 298
non diabetic and post-ischemic heart failure 2 | 200
tuberculosis 2 | 2,010
type II diabetes mellitus and post-ischemic heart failure 2 | 88

Tissue

Blood and immune system 21 | 16,909
Digestive Tract 21 | 17,369
Endocrine System 21 | 18,159
Female tissues 21 | 17,400
Male tissues 21 | 17,142
Nervous System 21 | 16,725
Skin and soft tissues 21 | 17,230
Cardiovascular System 20 | 15,192
Liver and Pancreas 20 | 16,750
Respiratory system 20 | 16,393
Urinary Tract 20 | 16,678

Target Family

GPCR 10 | 408
Non-IDG 9 | 12,091
Kinase 2 | 634

GO Function

Wnt-activated receptor activit... 21 | 21
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Frizzled-7 FZD7 Tbio GPCR -1.81873 66.4 345
Low-density lipoprotein receptor-related protein 5 LRP5 Tbio Non-IDG -3.10429 1247.5 302
Inactive tyrosine-protein kinase transmembrane receptor ROR1 ROR1 Tbio Kinase -1.38904 30.7 332
Frizzled-9 FZD9 Tbio GPCR -1.77240 61.8 380
Frizzled-8 FZD8 Tbio GPCR -1.64874 42.5 233
Secreted frizzled-related protein 3 FRZB Tbio Non-IDG -2.51623 308.4 252
Secreted frizzled-related protein 5 SFRP5 Tbio Non-IDG -1.81796 74.9 180
Frizzled-6 FZD6 Tbio GPCR -1.63747 44.5 260
Frizzled-5 FZD5 Tbio GPCR -1.54924 30.5 307
Pro-epidermal growth factor EGF Tbio Non-IDG -3.75933 4903.2 978