Development Level

Tbio 14 | 11,445

Disease

Ankylosing spondylitis 14 | 140
Behcet's disease 14 | 89
Cancer 14 | 2,499
Carcinoma 12 | 11,493
Acquired immunodeficiency syndrome 10 | 197
Arthritis 10 | 290
Herpes zoster 10 | 68
Hypersensitivity reaction type II disease 10 | 253
Juvenile rheumatoid arthritis 10 | 111
Uveitis 10 | 103
diabetes mellitus 10 | 1,728
Anemia 8 | 365
Birdshot chorioretinopathy 8 | 23
Hemochromatosis 8 | 54
Hepatitis B 8 | 108
Kidney disease 8 | 430
Leprosy 8 | 73
Liver disease 8 | 237
Multiple Sclerosis 8 | 540
Primary immunodeficiency disease 8 | 54
Skin disease 8 | 66
tuberculosis 8 | 2,010
Stevens-Johnson syndrome 7 | 92
Human immunodeficiency virus infectious disease 6 | 138
Psoriatic arthritis 6 | 86
psoriasis 6 | 6,694
Human immunodeficiency virus type 1, susceptibility to 4 | 26
Pre-Eclampsia 4 | 68
Psoriasis susceptibility 1 4 | 14
dermatomyositis 4 | 966
Astrocytoma, Pilocytic 2 | 3,081
Behcet's syndrome 2 | 50
Congenital adrenal hyperplasia 2 | 73
Dermatitis 2 | 157
Glioma 2 | 74
Nephritis 2 | 51
Retinal vasculitis 2 | 36
Rheumatoid arthritis 2 | 1,191
Schizophrenia 2 | 1,160
Spondyloarthropathy, Susceptibility To, 1 2 | 35
Synovitis 2 | 78
Takayasu's arteritis 2 | 53
adult high grade glioma 2 | 3,801
cutaneous lupus erythematosus 2 | 1,057
drug-induced hepatitis 2 | 44
glioblastoma 2 | 5,792
juvenile dermatomyositis 2 | 1,187
lung cancer 2 | 4,740
ovarian cancer 2 | 8,520
posterior fossa group A ependymoma 2 | 468
subependymal giant cell astrocytoma 2 | 2,287
Abnormal vision 1 | 52
Adverse reaction to drug 1 | 61
Arthritis, Psoriatic 1 | 14
Attenuation of retinal blood vessels 1 | 16
Autistic Disorder 1 | 364
Blind-spot enlargment 1 | 1
Blurred vision 1 | 19
Cataract 1 | 297
Chemical and Drug Induced Liver Injury 1 | 195
Chorioretinal abnormality 1 | 21
Drug-Related Side Effects and Adverse Reactions 1 | 62
Duchenne muscular dystrophy 1 | 601
Epiretinal Membrane 1 | 2
Genetic Predisposition to Disease 1 | 27
HIV Infections 1 | 102
Hepatitis B, Chronic 1 | 7
Inflammatory abnormality of the eye 1 | 10
Lens Opacities 1 | 231
Macular Edema, Cystoid 1 | 2
Macular holes 1 | 11
Multiple myeloma 1 | 1,332
Pallor of optic disc 1 | 39
Paranoia 1 | 20
Paranoid Schizophrenia 1 | 18
Parapsoriasis 1 | 6
Photodysphoria 1 | 121
Photophobia 1 | 121
Photoreceptor layer loss on macular OCT 1 | 1
Raised intraocular pressure 1 | 4
Retinal thinning 1 | 7
Scarred macula 1 | 3
Thrombocytopenia 1 | 197
Vitreous debris 1 | 1
Vitreous floaters 1 | 1
Vitritis 1 | 1
astrocytic glioma 1 | 2,597
astrocytoma 1 | 1,146
inflammatory breast cancer 1 | 286
intraductal papillary-mucinous adenoma (IPMA) 1 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 1 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 1 | 3,291
pancreatic ductal adenocarcinoma liver metastasis 1 | 1,962
primary Sjogren syndrome 1 | 735

Tissue

Blood and immune system 1 | 16,909
Cardiovascular System 1 | 15,192
Digestive Tract 1 | 17,369
Endocrine System 1 | 18,159
Female tissues 1 | 17,400
Liver and Pancreas 1 | 16,750
Male tissues 1 | 17,142
Nervous System 1 | 16,725
Respiratory system 1 | 16,393
Skin and soft tissues 1 | 17,230
Urinary Tract 1 | 16,678

Target Family

Non-IDG 14 | 12,091

GO Function

TAP binding 14 | 14
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

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