Development Level

Tbio 14 | 11,445
Tchem 2 | 1,598
Tclin 1 | 613
Tdark 1 | 6,588

IMPC Phenotype

abnormal heart morphology 2 | 162
decreased lean body mass 2 | 135
enlarged heart 2 | 210
preweaning lethality, complete... 2 | 979
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal digit morphology 1 | 10
abnormal embryo size 1 | 220
abnormal lens morphology 1 | 81
abnormal seminal vesicle morph... 1 | 114
abnormal social-conspecific in... 1 | 3
cataract 1 | 92
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 14 | 11,493
osteosarcoma 12 | 7,950
ovarian cancer 10 | 8,520
Cancer 8 | 2,499
glioblastoma 7 | 5,792
lung cancer 7 | 4,740
medulloblastoma, large-cell 7 | 6,241
psoriasis 7 | 6,694
atypical teratoid / rhabdoid tumor 6 | 5,112
Breast cancer 5 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
Multiple myeloma 4 | 1,332
adult high grade glioma 4 | 3,801
malignant mesothelioma 4 | 3,232
adrenocortical carcinoma 3 | 1,428
group 3 medulloblastoma 3 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
non-small cell lung cancer 3 | 2,890
primitive neuroectodermal tumor 3 | 3,035
Astrocytoma, Pilocytic 2 | 3,081
Breast Neoplasms 2 | 445
Carcinoma, Non-Small-Cell Lung 2 | 107
Glaucoma 2 | 239
Intellectual disability 2 | 1,016
Kidney cancer 2 | 2,613
Li-Fraumeni syndrome 2 | 13
Lymphoma 2 | 81
Male infertility 2 | 206
Mammary Neoplasms 2 | 425
Melanoma 2 | 711
Neoplasm Invasiveness 2 | 161
Pancreatic Neoplasm 2 | 85
Precancerous Conditions 2 | 80
Primary cutaneous T-cell lymphoma 2 | 29
Prostatic Neoplasms 2 | 495
Rheumatoid arthritis 2 | 1,191
active Crohn's disease 2 | 922
acute quadriplegic myopathy 2 | 1,158
astrocytic glioma 2 | 2,597
astrocytoma 2 | 1,146
breast carcinoma 2 | 1,638
diabetes mellitus 2 | 1,728
ependymoma 2 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
invasive ductal carcinoma 2 | 2,951
juvenile dermatomyositis 2 | 1,187
non-small cell lung carcinoma 2 | 317
pancreatic cancer 2 | 2,398
pituitary cancer 2 | 1,972
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis and treatment for 6 months 2 | 409
ulcerative colitis 2 | 1,819
Actinic keratosis 1 | 21
Acute necrotizing encephalitis 1 | 2
Adenocarcinoma 1 | 122
Adenocarcinoma Of Esophagus 1 | 14
Adrenal Gland Neoplasms 1 | 11
Anogenital venereal wart 1 | 14
Biliary tract cancer 1 | 19
Carcinogenesis 1 | 8
Carcinoma, Pancreatic Ductal 1 | 20
Carcinoma, Squamous Cell 1 | 110
Carcinoma, squamous cell of head and neck 1 | 31
Cell Transformation, Neoplastic 1 | 97
Cervix uteri carcinoma in situ 1 | 16
Decreased size of teeth 1 | 62
Decreased width of tooth 1 | 59
Diffuse large B-cell lymphoma 1 | 39
Encephalopathy, progressive 1 | 6
Esophageal atresia 1 | 43
Fibrous dysplasia 1 | 15
Genitourinary Neoplasms 1 | 3
Increased risk of pancreatic cancer 1 | 9
Inflammatory myofibroblastic tumor 1 | 8
LI-FRAUMENI SYNDROME 1 1 | 2
Laryngostenosis 1 | 10
Lymphoma, T-Cell, Cutaneous 1 | 22
Malignant Squamous Cell Neoplasm 1 | 17
Malignant neoplasm of pancreas 1 | 9
Malignant neoplasm of skin 1 | 15
Microdontia (disorder) 1 | 59
Microphthalmia 1 | 76
Neoplastic Cell Transformation 1 | 89
Nervous System Neoplasms 1 | 8
Papilloma 1 | 44
Progressive brain disease 1 | 6
Sarcoma 1 | 62
Sezary Syndrome 1 | 27
Sezary's disease 1 | 15
Skin Neoplasms 1 | 69
Squamous cell carcinoma of the head and neck 1 | 29
Stomach cancer 1 | 30
Sudden infant death syndrome 1 | 32
Thymoma 1 | 16
Tumors of Adrenal Cortex 1 | 3
Upper respiratory tract disease 1 | 15
Urogenital Neoplasms 1 | 3
Vulvar Lichen Sclerosus 1 | 2
Wolf-Hirschhorn syndrome 1 | 32
immunodeficiency-centromeric instability-facial anomalies syndrome 1 | 16

Tissue

Blood and immune system 18 | 16,909
Digestive Tract 18 | 17,369
Endocrine System 18 | 18,159
Female tissues 18 | 17,400
Liver and Pancreas 18 | 16,750
Male tissues 18 | 17,142
Nervous System 18 | 16,725
Skin and soft tissues 18 | 17,230
Urinary Tract 18 | 16,678
Respiratory system 17 | 16,393
Cardiovascular System 16 | 15,192

Target Family

Enzyme 6 | 4,145
Non-IDG 5 | 12,091
Transcription Factor 5 | 1,400
Epigenetic 2 | 242

GO Function

SUMO transferase activity 18 | 18
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E3 SUMO-protein ligase PIAS3 PIAS3 Tbio Transcription Factor -1.74449 53.4 174
RING finger protein 212B RNF212B Tdark Non-IDG 0.44 0.33 3
Probable E3 SUMO-protein ligase RNF212 RNF212 Tbio Enzyme -0.94925 8.45 87
E3 SUMO-protein ligase CBX4 CBX4 Tchem Epigenetic -1.32793 21.9 353
Mitochondrial ubiquitin ligase activator of NFKB 1 MUL1 Tbio Enzyme -2.41710 245.8 150
E3 SUMO-protein ligase PIAS1 PIAS1 Tbio Transcription Factor -1.86330 76.2 272
E3 SUMO-protein ligase PIAS2 PIAS2 Tbio Transcription Factor -1.84354 65.2 389
E3 SUMO-protein ligase NSE2 NSMCE2 Tbio Enzyme -1.37520 25.7 196
E3 ubiquitin-protein ligase Topors TOPORS Tbio Enzyme -1.94964 92.8 174
SUMO-conjugating enzyme UBC9 UBE2I Tbio Non-IDG -2.45979 267.1 368