Development Level

Tbio 33 | 11,445
Tdark 5 | 6,588

IMPC Phenotype

preweaning lethality, complete... 7 | 979
decreased total body fat amoun... 4 | 207
decreased circulating insulin ... 3 | 76
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
increased lean body mass 3 | 172
abnormal behavior 2 | 298
decreased circulating glucose ... 2 | 126
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased total body fat amoun... 2 | 134
preweaning lethality, incomple... 2 | 499
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal response to new envir... 1 | 10
abnormal response to tactile s... 1 | 17
abnormal sleep behavior 1 | 70
abnormal testis morphology 1 | 43
abnormal thymus morphology 1 | 7
alopecia 1 | 1
decreased IgE level 1 | 6
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating alkaline... 1 | 46
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating lactate ... 1 | 3
decreased fasted circulating g... 1 | 65
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
increased circulating glucose ... 1 | 24
increased circulating serum al... 1 | 22
increased exploration in new e... 1 | 8
increased grip strength 1 | 41
increased heart rate 1 | 23
increased heart weight 1 | 62
increased mean corpuscular hem... 1 | 36
limb grasping 1 | 41
long tibia 1 | 25
mammalian phenotype 1 | 17
small thymus 1 | 16
tremors 1 | 39
trunk curl 1 | 16

Disease

ovarian cancer 24 | 8,520
medulloblastoma, large-cell 20 | 6,241
osteosarcoma 20 | 7,950
psoriasis 16 | 6,694
Carcinoma 15 | 11,493
glioblastoma 15 | 5,792
atypical teratoid / rhabdoid tumor 12 | 5,112
ependymoma 12 | 4,679
Hypomyelinating leukodystrophy 6 10 | 26
group 3 medulloblastoma 10 | 4,104
Astrocytoma, Pilocytic 9 | 3,081
Tetanus 9 | 68
lung cancer 9 | 4,740
malignant mesothelioma 9 | 3,232
Pick disease 8 | 1,894
group 4 medulloblastoma 8 | 1,855
Schizophrenia 7 | 1,160
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
invasive ductal carcinoma 7 | 2,951
non-small cell lung cancer 7 | 2,890
oligodendroglioma 7 | 2,850
tuberculosis 7 | 2,010
adult high grade glioma 6 | 3,801
astrocytic glioma 6 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
lung adenocarcinoma 6 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
Multiple myeloma 5 | 1,332
Vici syndrome 5 | 14
cystic fibrosis 5 | 1,696
dermatomyositis 5 | 966
ductal carcinoma in situ 5 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
lung carcinoma 5 | 2,843
Alzheimer's disease 4 | 658
astrocytoma 4 | 1,146
primitive neuroectodermal tumor 4 | 3,035
subependymal giant cell astrocytoma 4 | 2,287
Absent reflex 3 | 92
Absent tendon reflex 3 | 92
Autosomal recessive predisposition 3 | 1,442
Bipolar Disorder 3 | 666
Botulism 3 | 24
Cataract 8 multiple types 3 | 33
Cerebellar Ataxia 3 | 304
Diarrhea 3 | 253
Dysarthria 3 | 192
Gaucher disease type 1 3 | 180
Reflex, Deep Tendon, Absent 3 | 92
acute quadriplegic myopathy 3 | 1,158
adrenocortical carcinoma 3 | 1,428
colon cancer 3 | 1,478
gastric cancer 3 | 459
juvenile dermatomyositis 3 | 1,187
non primary Sjogren syndrome sicca 3 | 891
pancreatic cancer 3 | 2,398
pancreatic carcinoma 3 | 562
progressive supranuclear palsy 3 | 676
spina bifida 3 | 1,074
ulcerative colitis 3 | 1,819
Anemia 2 | 365
Batten disease 2 | 13
Blepharoptosis 2 | 231
Cognitive delay 2 | 608
Colitis 2 | 54
Concave bridge of nose 2 | 195
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Difficulty walking 2 | 28
Down syndrome 2 | 499
Epilepsy 2 | 792
Familial hemophagocytic lymphohistiocytosis 4 2 | 2
Gastroenteritis 2 | 41
Global developmental delay 2 | 608
Heart disease 2 | 306
Hermansky-Pudlak syndrome 2 | 42
Intellectual disability 2 | 1,016
Kidney Failure 2 | 111
Liver Cirrhosis, Experimental 2 | 769
MAJOR AFFECTIVE DISORDER 2 2 | 22
Male infertility 2 | 206
Mental and motor retardation 2 | 608
Multiple Sclerosis 2 | 540
Osteogenesis imperfecta type 15 2 | 3
Osteoporosis 2 | 363
Pancreatic agenesis 2 | 17
Rheumatoid arthritis 2 | 1,191
Waldenstrons macroglobulinemia 2 | 765
active Crohn's disease 2 | 922
aldosterone-producing adenoma 2 | 665
axial spondyloarthropathy 2 | 28
breast carcinoma 2 | 1,638
interstitial cystitis 2 | 2,312
nasopharyngeal carcinoma 2 | 1,058
pediatric high grade glioma 2 | 1,064
pituitary cancer 2 | 1,972
tuberculosis and treatment for 6 months 2 | 409
Human granulocytic anaplasmosis 1 | 7
Progressive microcephaly 1 | 32
Sparse pubic hair 1 | 31

Tissue

Blood and immune system 38 | 16,909
Digestive Tract 38 | 17,369
Endocrine System 38 | 18,159
Female tissues 38 | 17,400
Liver and Pancreas 38 | 16,750
Male tissues 38 | 17,142
Nervous System 38 | 16,725
Respiratory system 38 | 16,393
Skin and soft tissues 38 | 17,230
Urinary Tract 38 | 16,678
Cardiovascular System 37 | 15,192

Target Family

Non-IDG 38 | 12,091

GO Function

SNAP receptor activity 38 | 38
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Syntaxin-2 STX2 Tbio Non-IDG -2.93775 902.6 197
Syntaxin-1A STX1A Tbio Non-IDG -2.86666 716.9 478
Syntaxin-8 STX8 Tbio Non-IDG -2.59234 391.5 134
Synaptosomal-associated protein 25 SNAP25 Tbio Non-IDG -2.61491 385.0 821
Vesicle-associated membrane protein 2 VAMP2 Tbio Non-IDG -2.53335 323.7 203
Synaptosomal-associated protein 23 SNAP23 Tbio Non-IDG -2.11951 135.0 292
Vesicle-associated membrane protein 3 VAMP3 Tbio Non-IDG -1.98652 94.2 182
Syntaxin-4 STX4 Tbio Non-IDG -1.95295 84.2 207
Vesicle-associated membrane protein 7 VAMP7 Tbio Non-IDG -1.87033 83.5 146
Syntaxin-5 STX5 Tbio Non-IDG -1.88347 75.4 123