Development Level

Tbio 50 | 11,651
Tdark 4 | 6,593
Tchem 2 | 1,388
Tclin 1 | 612

IMPC Phenotype

abnormal behavior 2 | 298
decreased circulating glucose ... 2 | 126
preweaning lethality, incomple... 2 | 499
abnormal coat- hair morphology 1 | 19
abnormal coping response 1 | 1
abnormal cornea morphology 1 | 31
abnormal digestive system phys... 1 | 1
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal heart morphology 1 | 162
abnormal skin morphology 1 | 50
anophthalmia 1 | 33
decreased T cell number 1 | 15
decreased body weight 1 | 161
decreased caudal vertebrae num... 1 | 53
decreased circulating free fat... 1 | 31
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased mean corpuscular hem... 1 | 31
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
enlarged heart 1 | 210
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired righting response 1 | 26
increased CD4-positive, alpha ... 1 | 4
increased circulating alkaline... 1 | 122
increased circulating sodium l... 1 | 71
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased vertical activity 1 | 24
preweaning lethality, complete... 1 | 979
short tibia 1 | 97

Disease

Carcinoma 37 | 11,493
osteosarcoma 37 | 7,950
ovarian cancer 31 | 8,520
psoriasis 31 | 6,694
lung cancer 22 | 4,740
medulloblastoma, large-cell 22 | 6,241
Breast cancer 20 | 3,578
interstitial cystitis 17 | 2,312
glioblastoma 16 | 5,792
astrocytic glioma 15 | 2,597
ependymoma 15 | 4,679
Cancer 14 | 2,499
invasive ductal carcinoma 14 | 2,951
oligodendroglioma 14 | 2,850
group 4 medulloblastoma 13 | 1,855
lung carcinoma 13 | 2,843
malignant mesothelioma 13 | 3,232
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
tuberculosis 12 | 2,010
atypical teratoid / rhabdoid tumor 11 | 5,112
colon cancer 11 | 1,478
group 3 medulloblastoma 11 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
pancreatic cancer 11 | 2,398
ulcerative colitis 11 | 1,819
Astrocytoma, Pilocytic 10 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
non-small cell lung cancer 10 | 2,890
lung adenocarcinoma 9 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
subependymal giant cell astrocytoma 9 | 2,287
Kidney cancer 8 | 2,613
cystic fibrosis 8 | 1,696
ductal carcinoma in situ 8 | 1,745
primary Sjogren syndrome 8 | 735
Schizophrenia 7 | 1,160
adult high grade glioma 7 | 3,801
cutaneous lupus erythematosus 7 | 1,057
dermatomyositis 7 | 966
juvenile dermatomyositis 7 | 1,187
pituitary cancer 7 | 1,972
primitive neuroectodermal tumor 7 | 3,035
Down syndrome 6 | 499
acute myeloid leukemia 6 | 783
acute quadriplegic myopathy 6 | 1,158
pancreatic carcinoma 6 | 562
Breast Neoplasms 5 | 445
adrenocortical carcinoma 5 | 1,428
astrocytoma 5 | 1,146
breast carcinoma 5 | 1,638
Duchenne muscular dystrophy 4 | 601
Lymphoproliferative syndrome 4 | 58
Mammary Neoplasms 4 | 425
Multiple myeloma 4 | 1,332
Pick disease 4 | 1,894
Rheumatoid arthritis 4 | 1,191
Silver-Russell syndrome 4 | 39
Waldenstrons macroglobulinemia 4 | 765
active ulcerative colitis 4 | 764
esophageal adenocarcinoma 4 | 737
nasopharyngeal carcinoma 4 | 1,058
pediatric high grade glioma 4 | 1,064
spina bifida 4 | 1,074
Agammaglobulinemia 3 | 34
Autosomal recessive predisposition 3 | 1,442
Congenital heart disease 3 | 93
Diarrhea 3 | 253
Encephalitis 3 | 64
Hepatomegaly 3 | 285
Immunologic Deficiency Syndromes 3 | 113
Liver Cirrhosis, Experimental 3 | 769
Neoplasm Invasiveness 3 | 161
Noonan syndrome 3 | 34
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
chronic lymphosyte leukemia 3 | 204
diabetes mellitus 3 | 1,728
non primary Sjogren syndrome sicca 3 | 891
posterior fossa group A ependymoma 3 | 468
primary pancreatic ductal adenocarcinoma 3 | 1,109
Acquired metabolic disease 2 | 336
Arthritis 2 | 290
Atopic dermatitis 2 | 952
Exophthalmos 2 | 112
Neuropathy 2 | 261
Parkinson's disease 2 | 392
Prominent eyes 2 | 96
Prominent globes 2 | 96
Prostatic Neoplasms 2 | 495
Proteinuria 2 | 144
Protruding eyes 2 | 96
Strabismus 2 | 270
Urinary bladder cancer 2 | 36
atypical teratoid/rhabdoid tumor 2 | 357
chronic rhinosinusitis 2 | 512
cystic fibrosis and chronic rhinosinusitis 2 | 214
hereditary spastic paraplegia 2 | 318
medulloblastoma 2 | 720
posterior fossa group B ependymoma 2 | 416
progressive supranuclear palsy 2 | 676
tuberculosis and treatment for 6 months 2 | 409

Tissue

Digestive Tract 56 | 17,369
Endocrine System 56 | 18,159
Skin and soft tissues 56 | 17,230
Liver and Pancreas 55 | 16,750
Male tissues 55 | 17,142
Urinary Tract 55 | 16,678
Blood and immune system 54 | 16,909
Cardiovascular System 54 | 15,192
Female tissues 54 | 17,400
Nervous System 54 | 16,725
Respiratory system 54 | 16,393

Target Family

Non-IDG 49 | 12,091
Enzyme 7 | 4,145
Kinase 1 | 634

GO Function

SH3-SH2 adaptor activity 57 | 57
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Guanine nucleotide exchange factor VAV3 VAV3 Tbio Non-IDG -1.82116 74.0 249
Src kinase-associated phosphoprotein 1 SKAP1 Tbio Enzyme -1.31527 25.2 175
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 PAG1 Tbio Non-IDG -1.69647 50.1 216
Cytoplasmic protein NCK1 NCK1 Tbio Non-IDG -2.25032 186.5 398
Signal-transducing adaptor protein 1 STAP1 Tbio Non-IDG -0.38628 3.43 177
Cytoplasmic protein NCK2 NCK2 Tbio Non-IDG -1.57587 36.4 241
B-cell linker protein BLNK Tbio Non-IDG -2.82834 659.4 509
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -3.02404 981.4 501
Tyrosine-protein phosphatase non-receptor type 11 PTPN11 Tchem Enzyme -3.11032 1400.0 1077
Epidermal growth factor receptor kinase substrate 8 EPS8 Tbio Enzyme -1.84834 81.7 254