Development Level

Tbio 96 | 11,445
Tchem 17 | 1,598
Tdark 8 | 6,588
Tclin 4 | 613

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

abnormal behavior 6 | 298
preweaning lethality, complete... 6 | 979
abnormal embryo size 3 | 220
decreased circulating insulin ... 3 | 76
embryonic lethality prior to t... 3 | 278
hyperactivity 3 | 148
preweaning lethality, incomple... 3 | 499
small testis 3 | 58
abnormal behavioral response t... 2 | 66
abnormal lens morphology 2 | 81
abnormal seminal vesicle morph... 2 | 114
cataract 2 | 92
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased total body fat amoun... 2 | 207
embryonic growth retardation 2 | 106
embryonic lethality prior to o... 2 | 239
impaired glucose tolerance 2 | 75
increased bone mineral content 2 | 108
increased circulating HDL chol... 2 | 80
increased circulating LDL chol... 2 | 13
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
increased monocyte cell number 2 | 63
increased neutrophil cell numb... 2 | 46
abnormal blood vessel morpholo... 1 | 5
abnormal bone structure 1 | 187
abnormal chorioallantoic fusio... 1 | 8
abnormal coat- hair morphology 1 | 19
abnormal cornea morphology 1 | 31
abnormal embryo development 1 | 7
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal eye size 1 | 7
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal iris morphology 1 | 13
abnormal iris pigmentation 1 | 4
abnormal maxilla morphology 1 | 17
abnormal midbrain development 1 | 20
abnormal nail morphology 1 | 8
abnormal neural tube closure 1 | 46
abnormal pericardium morpholog... 1 | 26
abnormal pharyngeal arch morph... 1 | 8
abnormal somite shape 1 | 5
abnormal spleen morphology 1 | 55
abnormal stomach morphology 1 | 10
abnormal testis morphology 1 | 43
abnormal vibrissa morphology 1 | 25
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
absent pinna reflex 1 | 23
absent urinary bladder 1 | 1
cardiovascular system phenotyp... 1 | 36
corneal opacity 1 | 32
decreased blood urea nitrogen ... 1 | 51
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating creatini... 1 | 39
decreased circulating iron lev... 1 | 32
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart rate variabili... 1 | 13
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased startle reflex 1 | 75
edema 1 | 59
enlarged epididymis 1 | 31
enlarged spleen 1 | 41
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased circulating alkaline... 1 | 122
increased circulating iron lev... 1 | 30
increased grip strength 1 | 41
increased heart left ventricle... 1 | 4
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
increased prepulse inhibition 1 | 32
increased spleen weight 1 | 10
long tibia 1 | 25
pale yolk sac 1 | 25
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
polycystic kidney 1 | 15
short tibia 1 | 97
small kidney 1 | 16
small spleen 1 | 19
stereotypic behavior 1 | 3
thrombocytopenia 1 | 56
trunk curl 1 | 16

Disease

Carcinoma 89 | 11,493
ovarian cancer 72 | 8,520
osteosarcoma 64 | 7,950
medulloblastoma, large-cell 63 | 6,241
glioblastoma 54 | 5,792
atypical teratoid / rhabdoid tumor 53 | 5,112
ependymoma 48 | 4,679
lung cancer 48 | 4,740
psoriasis 45 | 6,694
group 3 medulloblastoma 41 | 4,104
adult high grade glioma 36 | 3,801
primitive neuroectodermal tumor 36 | 3,035
Astrocytoma, Pilocytic 35 | 3,081
Breast cancer 35 | 3,578
Cancer 34 | 2,499
malignant mesothelioma 34 | 3,232
oligodendroglioma 33 | 2,850
subependymal giant cell astrocytoma 32 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 29 | 2,955
invasive ductal carcinoma 29 | 2,951
lung carcinoma 29 | 2,843
intraductal papillary-mucinous carcinoma (IPMC) 28 | 2,989
Kidney cancer 26 | 2,613
lung adenocarcinoma 26 | 2,716
non-small cell lung cancer 26 | 2,890
astrocytic glioma 24 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,291
pancreatic cancer 24 | 2,398
interstitial cystitis 23 | 2,312
Pick disease 22 | 1,894
group 4 medulloblastoma 20 | 1,855
tuberculosis 19 | 2,010
Schizophrenia 18 | 1,160
pituitary cancer 18 | 1,972
juvenile dermatomyositis 17 | 1,187
ulcerative colitis 17 | 1,819
breast carcinoma 16 | 1,638
astrocytoma 15 | 1,146
diabetes mellitus 15 | 1,728
Rheumatoid arthritis 14 | 1,191
cutaneous lupus erythematosus 14 | 1,057
Autosomal recessive predisposition 13 | 1,442
colon cancer 13 | 1,478
dermatomyositis 13 | 966
ductal carcinoma in situ 13 | 1,745
gastric carcinoma 13 | 807
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,962
pediatric high grade glioma 13 | 1,064
acute quadriplegic myopathy 12 | 1,158
cystic fibrosis 12 | 1,696
primary Sjogren syndrome 12 | 735
primary pancreatic ductal adenocarcinoma 11 | 1,109
Alzheimer's disease 10 | 658
Down syndrome 10 | 499
Intellectual disability 10 | 1,016
Multiple myeloma 10 | 1,332
Autistic Disorder 9 | 364
Duchenne muscular dystrophy 9 | 601
Epilepsy 9 | 792
Liver Cirrhosis, Experimental 9 | 769
active Crohn's disease 9 | 922
spina bifida 9 | 1,074
Parkinson's disease 8 | 392
adrenocortical carcinoma 8 | 1,428
esophageal adenocarcinoma 8 | 737
Bipolar Disorder 7 | 666
Hypertensive disease 7 | 292
Kidney disease 7 | 430
Waldenstrons macroglobulinemia 7 | 765
progressive supranuclear palsy 7 | 676
Acquired metabolic disease 6 | 336
Atopic dermatitis 6 | 952
Fatigue 6 | 182
Muscle hypotonia 6 | 571
Prostatic Neoplasms 6 | 495
Recurrent respiratory infections 6 | 141
active ulcerative colitis 6 | 764
acute myeloid leukemia 6 | 783
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 510
Cognitive delay 5 | 608
Concave bridge of nose 5 | 195
Depressed nasal bridge 5 | 195
Depressed nasal root/bridge 5 | 195
Dull intelligence 5 | 645
Global developmental delay 5 | 608
Heart disease 5 | 306
Hypertension 5 | 396
Liver cancer 5 | 604
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental and motor retardation 5 | 608
Mental deficiency 5 | 645
Multiple Sclerosis 5 | 540
Neurodegenerative disease 5 | 414
Orbital separation excessive 5 | 244
Poor school performance 5 | 645
aldosterone-producing adenoma 5 | 665
atypical teratoid/rhabdoid tumor 5 | 357
non primary Sjogren syndrome sicca 5 | 891
tuberculosis and treatment for 6 months 5 | 409

Tissue

Digestive Tract 123 | 17,369
Endocrine System 123 | 18,159
Female tissues 123 | 17,400
Skin and soft tissues 123 | 17,230
Blood and immune system 122 | 16,909
Liver and Pancreas 122 | 16,750
Male tissues 122 | 17,142
Nervous System 122 | 16,725
Urinary Tract 121 | 16,678
Respiratory system 120 | 16,393
Cardiovascular System 118 | 15,192

Target Family

Non-IDG 79 | 12,091
Enzyme 38 | 4,145
Kinase 6 | 634
GPCR 1 | 408
Ion Channel 1 | 344

GO Function

SH3 domain binding 125 | 125
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Putative pituitary tumor-transforming gene 3 protein PTTG3P Tdark Non-IDG 0.00000 0
Securin-2 PTTG2 Tdark Non-IDG -0.58734 3.76 86
Disintegrin and metalloproteinase domain-containing protein 12 ADAM12 Tchem Enzyme -2.28901 214.1 347
Rho GTPase-activating protein 6 ARHGAP6 Tbio Enzyme -0.85601 8.06 45
Apoptosis-stimulating of p53 protein 2 TP53BP2 Tbio Non-IDG -1.85307 72.5 189
Ras/Rap GTPase-activating protein SynGAP SYNGAP1 Tbio Enzyme -1.91757 81.2 178
ERBB receptor feedback inhibitor 1 ERRFI1 Tbio Non-IDG -1.86682 77.3 148
SH3 domain-binding glutamic acid-rich-like protein 2 SH3BGRL2 Tbio Non-IDG -0.26398 0.71 9
CD2-associated protein CD2AP Tbio Non-IDG -3.44533 2735.9 82
Disintegrin and metalloproteinase domain-containing protein 15 ADAM15 Tbio Enzyme -1.87408 84.1 301