Development Level

Tbio 21 | 11,651
Tchem 6 | 1,388
Tclin 4 | 612
Tdark 1 | 6,593

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal behavior 2 | 298
abnormal bone structure 1 | 187
abnormal coat- hair morphology 1 | 19
abnormal femur morphology 1 | 14
abnormal spleen morphology 1 | 55
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased red blood cell distr... 1 | 41
embryonic lethality prior to o... 1 | 239
improved glucose tolerance 1 | 79
increased body length 1 | 32
increased circulating alkaline... 1 | 122
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
long tibia 1 | 25
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 26 | 11,493
ovarian cancer 25 | 8,520
osteosarcoma 22 | 7,950
psoriasis 16 | 6,694
Cancer 13 | 2,499
Kidney cancer 12 | 2,613
atypical teratoid / rhabdoid tumor 12 | 5,112
glioblastoma 11 | 5,792
lung cancer 11 | 4,740
non-small cell lung cancer 11 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
medulloblastoma, large-cell 10 | 6,241
tuberculosis 10 | 2,010
Breast cancer 9 | 3,578
adult high grade glioma 9 | 3,801
subependymal giant cell astrocytoma 9 | 2,287
Astrocytoma, Pilocytic 8 | 3,081
group 3 medulloblastoma 8 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
invasive ductal carcinoma 8 | 2,951
oligodendroglioma 8 | 2,850
primary Sjogren syndrome 8 | 735
ulcerative colitis 8 | 1,819
astrocytoma 7 | 1,146
ependymoma 7 | 4,679
group 4 medulloblastoma 7 | 1,855
interstitial cystitis 7 | 2,312
lung carcinoma 7 | 2,843
primitive neuroectodermal tumor 6 | 3,035
Pick disease 5 | 1,894
adrenocortical carcinoma 5 | 1,428
astrocytic glioma 5 | 2,597
diabetes mellitus 5 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
malignant mesothelioma 5 | 3,232
pancreatic cancer 5 | 2,398
spina bifida 5 | 1,074
Autosomal recessive predisposition 4 | 1,442
Rheumatoid arthritis 4 | 1,191
Schizophrenia 4 | 1,160
cutaneous lupus erythematosus 4 | 1,057
cystic fibrosis 4 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
Arthritis 3 | 290
Bipolar Disorder 3 | 666
Blastic phase chronic myeloid leukemia 3 | 58
Chronic Myelocytic Leukemia Accelerated Phase 3 | 59
Chronic phase chronic myeloid leukemia 3 | 45
Crohn's disease 3 | 321
Dull intelligence 3 | 645
Fatigue 3 | 182
Hypertension 3 | 396
Intellectual disability 3 | 1,016
Liver Cirrhosis, Experimental 3 | 769
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Multiple myeloma 3 | 1,332
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 3 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 3 | 47
Poor school performance 3 | 645
Prostatic Neoplasms 3 | 495
Renal Cell Carcinoma 3 | 214
Waldenstrons macroglobulinemia 3 | 765
colon cancer 3 | 1,478
ductal carcinoma in situ 3 | 1,745
juvenile dermatomyositis 3 | 1,187
Alzheimer's disease 2 | 658
Amyotrophic lateral sclerosis 2 | 451
Atopic dermatitis 2 | 952
Carcinoma, Hepatocellular 2 | 228
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diabetes Mellitus, Type 2 2 | 142
Down syndrome 2 | 499
Failure to gain weight 2 | 365
Hypereosinophilic syndrome 2 | 71
Lissencephaly 2 | 69
Liver carcinoma 2 | 240
Melanoma 2 | 711
Mouth Neoplasms 2 | 55
Muscle Spasticity 2 | 195
Myocardial Ischemia 2 | 169
Neoplasm Invasiveness 2 | 161
Neurodegenerative disease 2 | 414
Parkinson's disease 2 | 392
Pediatric failure to thrive 2 | 365
Stomach Neoplasms 2 | 300
active ulcerative colitis 2 | 764
acute quadriplegic myopathy 2 | 1,158
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
breast carcinoma 2 | 1,638
chronic lymphosyte leukemia 2 | 204
glioblastoma multiforme 2 | 142
hepatocellular carcinoma 2 | 547
lung adenocarcinoma 2 | 2,716
mucosa-associated lymphoid tissue lymphoma 2 | 484
pancreatic carcinoma 2 | 562
pediatric high grade glioma 2 | 1,064
primary pancreatic ductal adenocarcinoma 2 | 1,109
urothelial carcinoma 2 | 318

Tissue

Blood and immune system 32 | 16,909
Digestive Tract 32 | 17,369
Endocrine System 32 | 18,159
Female tissues 32 | 17,400
Liver and Pancreas 32 | 16,750
Male tissues 32 | 17,142
Respiratory system 32 | 16,393
Skin and soft tissues 32 | 17,230
Urinary Tract 32 | 16,678
Cardiovascular System 31 | 15,192
Nervous System 30 | 16,725

Target Family

Non-IDG 17 | 12,091
Enzyme 7 | 4,145
Kinase 7 | 634
Ion Channel 1 | 344

GO Function

SH2 domain binding 32 | 32
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.14835 1437.4 1136
Src kinase-associated phosphoprotein 1 SKAP1 Tbio Enzyme -1.31527 25.2 175
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 PAG1 Tbio Non-IDG -1.69647 50.1 216
Rho GTPase-activating protein 7 DLC1 Tbio Enzyme -1.93185 106.7 137
Sequestosome-1 SQSTM1 Tbio Non-IDG -2.78728 635.1 766
RUN and FYVE domain-containing protein 1 RUFY1 Tbio Non-IDG -0.58196 5.60 145
Nuclear pore glycoprotein p62 NUP62 Tbio Non-IDG -1.80390 62.5 241
Receptor of activated protein C kinase 1 RACK1 Tbio Non-IDG -2.60480 437.9 300
Tyrosine-protein kinase ABL1 ABL1 Tclin Kinase -3.51854 3418.5 1661
Proto-oncogene tyrosine-protein kinase Src SRC Tclin Kinase -4.00292 9201.7 1455