Development Level

Tbio 9 | 11,445
Tchem 3 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 2 | 979
preweaning lethality, incomple... 2 | 499
abnormal bone structure 1 | 187
abnormal sensory capabilities-... 1 | 8
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating alkaline... 1 | 46
decreased eosinophil cell numb... 1 | 24
decreased mean platelet volume 1 | 25
decreased prepulse inhibition 1 | 82
embryonic lethality prior to t... 1 | 278
enlarged seminal vesicle 1 | 10
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased circulating magnesiu... 1 | 10
short tibia 1 | 97

Disease

atypical teratoid / rhabdoid tumor 10 | 5,112
ependymoma 10 | 4,679
glioblastoma 10 | 5,792
ovarian cancer 10 | 8,520
osteosarcoma 9 | 7,950
adult high grade glioma 8 | 3,801
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
invasive ductal carcinoma 8 | 2,951
lung cancer 8 | 4,740
pituitary cancer 8 | 1,972
psoriasis 8 | 6,694
Breast cancer 7 | 3,578
Cancer 7 | 2,499
Carcinoma 7 | 11,493
juvenile dermatomyositis 7 | 1,187
pancreatic cancer 7 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
Liver Cirrhosis, Experimental 6 | 769
ductal carcinoma in situ 6 | 1,745
group 3 medulloblastoma 6 | 4,104
lung adenocarcinoma 6 | 2,716
lung carcinoma 6 | 2,843
medulloblastoma, large-cell 6 | 6,241
subependymal giant cell astrocytoma 6 | 2,287
Astrocytoma, Pilocytic 5 | 3,081
Duchenne muscular dystrophy 5 | 601
acute quadriplegic myopathy 5 | 1,158
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
non-small cell lung cancer 5 | 2,890
primitive neuroectodermal tumor 5 | 3,035
Becker muscular dystrophy 4 | 191
Down syndrome 4 | 499
astrocytic glioma 4 | 2,597
breast carcinoma 4 | 1,638
malignant mesothelioma 4 | 3,232
oligodendroglioma 4 | 2,850
Animal Mammary Neoplasms 3 | 136
Mammary Neoplasms, Animal 3 | 136
Neoplasm Invasiveness 3 | 161
Rheumatoid arthritis 3 | 1,191
Schizophrenia 3 | 1,160
Vasospasm, Intracranial 3 | 5
Weight Gain 3 | 100
adrenocortical carcinoma 3 | 1,428
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
colon cancer 3 | 1,478
diabetes mellitus 3 | 1,728
interstitial cystitis 3 | 2,312
limb girdle muscular dystrophy 2A 3 | 213
Alzheimer's disease 2 | 658
Bipolar Disorder 2 | 666
Brain Neoplasms 2 | 33
Chemical and Drug Induced Liver Injury 2 | 195
Chronic obstructive pulmonary disease 2 | 184
Degenerative polyarthritis 2 | 115
Depressive disorder 2 | 409
Diabetes Mellitus, Experimental 2 | 108
Diabetes Mellitus, Non-Insulin-Dependent 2 | 145
Diabetes Mellitus, Type 2 2 | 142
Heart disease 2 | 306
Kidney cancer 2 | 2,613
Mammary Neoplasms, Experimental 2 | 154
Mental Depression 2 | 333
Mood Disorders 2 | 184
Myocardial Infarction 2 | 151
Osteoarthritis 2 | 184
Pick disease 2 | 1,894
gastric cancer 2 | 459
group 4 medulloblastoma 2 | 1,855
primary pancreatic ductal adenocarcinoma 2 | 1,109
sarcoidosis 2 | 370
sonic hedgehog group medulloblastoma 2 | 467
tuberculosis 2 | 2,010
urothelial carcinoma 2 | 318
Acquired immunodeficiency syndrome 1 | 197
Barrett's esophagus 1 | 182
Brain Injuries 1 | 65
Brain disease 1 | 96
Carcinoma, Renal Cell 1 | 124
Carcinoma, Squamous Cell 1 | 110
Cardiomegaly 1 | 116
Cerebral Hemorrhage 1 | 42
Common variable immunodeficiency 1 | 101
Familial primary pulmonary hypertension 1 | 11
Hair shaft abnormalities 1 | 30
Leukemia, Myelocytic, Acute 1 | 120
Leukemia, Myeloid, Acute 1 | 105
Ovarian Neoplasms 1 | 102
Palmoplantar keratosis 1 | 74
Primary pulmonary hypertension 1 | 14
Pulmonary hypertension 1 | 85
Renal Cell Carcinoma 1 | 214
Ridged nails 1 | 14
Systemic scleroderma 1 | 60
Vaccinia 1 | 36
chronic kidney disease 1 | 90
hair abnormalities (non-specific) 1 | 30
interstitial lung disease 1 | 298
ovarian neoplasm 1 | 99

Tissue

Blood and immune system 13 | 16,909
Cardiovascular System 13 | 15,192
Digestive Tract 13 | 17,369
Endocrine System 13 | 18,159
Female tissues 13 | 17,400
Liver and Pancreas 13 | 16,750
Male tissues 13 | 17,142
Respiratory system 13 | 16,393
Skin and soft tissues 13 | 17,230
Urinary Tract 13 | 16,678
Nervous System 12 | 16,725

Target Family

Non-IDG 10 | 12,091
Enzyme 1 | 4,145
Ion Channel 1 | 344
Transporter 1 | 473

GO Function

S100 protein binding 13 | 13
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 ATP2A2 Tbio Transporter -2.87498 737.3 295
Protein S100-A11 S100A11 Tbio Non-IDG -2.01412 110.0 311
Neuroblast differentiation-associated protein AHNAK AHNAK Tbio Non-IDG -1.65508 52.1 119
Protein S100-A1 S100A1 Tbio Non-IDG -2.47381 296.0 704
Advanced glycosylation end product-specific receptor AGER Tchem Non-IDG -2.29145 187.3 589
Ras GTPase-activating-like protein IQGAP1 IQGAP1 Tbio Enzyme -2.27732 224.8 291
Protein S100-A6 S100A6 Tbio Non-IDG -2.72619 530.5 328
Protein S100-B S100B Tchem Non-IDG -3.48893 3193.2 903
Ezrin EZR Tbio Non-IDG -2.99865 981.3 1088
Annexin A11 ANXA11 Tbio Non-IDG -1.68299 54.0 203