Development Level

Tbio 55 | 11,445
Tdark 14 | 6,588
Tchem 1 | 1,598
Tclin 1 | 613

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 4 | 979
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
decreased circulating choleste... 2 | 93
decreased circulating triglyce... 2 | 79
decreased grip strength 2 | 116
abnormal brain morphology 1 | 13
abnormal coat- hair morphology 1 | 19
abnormal eye anterior chamber ... 1 | 9
abnormal eye morphology 1 | 68
abnormal joint morphology 1 | 23
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal sensory capabilities-... 1 | 8
abnormal vibrissa morphology 1 | 25
brachydactyly 1 | 19
decreased IgE level 1 | 6
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating fructosa... 1 | 30
decreased circulating serum al... 1 | 82
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased threshold for audito... 1 | 26
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
hydroencephaly 1 | 14
hyperactivity 1 | 148
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating free fat... 1 | 20
increased circulating fructosa... 1 | 13
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased lean body mass 1 | 172
increased mature B cell number 1 | 1
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
male infertility 1 | 123
short tibia 1 | 97
syndactyly 1 | 23
thin ventricular wall 1 | 24
tremors 1 | 39

Disease

Carcinoma 67 | 11,493
osteosarcoma 41 | 7,950
medulloblastoma, large-cell 38 | 6,241
ovarian cancer 37 | 8,520
atypical teratoid / rhabdoid tumor 36 | 5,112
Kidney cancer 34 | 2,613
glioblastoma 33 | 5,792
ependymoma 27 | 4,679
psoriasis 27 | 6,694
adult high grade glioma 25 | 3,801
group 3 medulloblastoma 24 | 4,104
primitive neuroectodermal tumor 24 | 3,035
Astrocytoma, Pilocytic 19 | 3,081
invasive ductal carcinoma 19 | 2,951
non-small cell lung cancer 19 | 2,890
lung cancer 18 | 4,740
subependymal giant cell astrocytoma 18 | 2,287
Breast cancer 17 | 3,578
astrocytic glioma 17 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,989
lung adenocarcinoma 17 | 2,716
oligodendroglioma 17 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,955
malignant mesothelioma 16 | 3,232
lung carcinoma 15 | 2,843
Cancer 14 | 2,499
ductal carcinoma in situ 14 | 1,745
Pick disease 13 | 1,894
group 4 medulloblastoma 13 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
pancreatic cancer 12 | 2,398
pituitary cancer 12 | 1,972
tuberculosis 11 | 2,010
ulcerative colitis 11 | 1,819
breast carcinoma 10 | 1,638
interstitial cystitis 10 | 2,312
spina bifida 10 | 1,074
Intellectual disability 9 | 1,016
cystic fibrosis 8 | 1,696
Aarskog syndrome 7 | 12
Liver cancer 7 | 604
cutaneous lupus erythematosus 7 | 1,057
aldosterone-producing adenoma 6 | 665
colon cancer 6 | 1,478
medulloblastoma 6 | 720
Chronic Lymphocytic Leukemia 5 | 262
acute quadriplegic myopathy 5 | 1,158
adrenocortical carcinoma 5 | 1,428
astrocytoma 5 | 1,146
gastric carcinoma 5 | 807
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
primary Sjogren syndrome 5 | 735
primary pancreatic ductal adenocarcinoma 5 | 1,109
Cardiovascular system disease 4 | 246
Endometrial cancer 4 | 311
Melanoma 4 | 711
Neuropathy 4 | 261
Prostatic Neoplasms 4 | 495
Short stature 4 | 531
Skin cancer 4 | 469
active Crohn's disease 4 | 922
esophageal adenocarcinoma 4 | 737
mucosa-associated lymphoid tissue lymphoma 4 | 484
Acquired scoliosis 3 | 281
Alzheimer's disease 3 | 658
Amyotrophic lateral sclerosis 3 | 451
Bipolar Disorder 3 | 666
Blepharoptosis 3 | 231
Cryptorchidism 3 | 296
Curvature of spine 3 | 282
Downward slant of palpebral fissure 3 | 158
Dull intelligence 3 | 645
Joint hyperflexibility 3 | 78
Liver Cirrhosis, Experimental 3 | 769
Low intelligence 3 | 645
Low-set, posteriorly rotated ears 3 | 110
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Multiple Sclerosis 3 | 540
Orbital separation excessive 3 | 244
Pectus excavatum 3 | 100
Poor school performance 3 | 645
Rheumatoid arthritis 3 | 1,191
Schizophrenia 3 | 1,160
Short neck 3 | 140
Strabismus 3 | 270
Substance-Related Disorders 3 | 115
X- linked recessive 3 | 110
dermatomyositis 3 | 966
fibroadenoma 3 | 559
gastric cancer 3 | 459
interstitial lung disease 3 | 298
progressive supranuclear palsy 3 | 676
Bilateral fifth finger clinodactyly 2 | 110
Byzanthine arch palate 2 | 194
Curvature of little finger 2 | 110
Delayed bone age 2 | 136
Hepatomegaly 2 | 285
Hypertension 2 | 396
pediatric high grade glioma 2 | 1,064

Tissue

Blood and immune system 71 | 16,909
Digestive Tract 71 | 17,369
Endocrine System 71 | 18,159
Female tissues 71 | 17,400
Male tissues 71 | 17,142
Respiratory system 71 | 16,393
Urinary Tract 71 | 16,678
Liver and Pancreas 70 | 16,750
Nervous System 69 | 16,725
Skin and soft tissues 69 | 17,230
Cardiovascular System 68 | 15,192

Target Family

Non-IDG 67 | 12,091
Kinase 3 | 634
Enzyme 1 | 4,145

GO Function

Rho guanyl-nucleotide exchange... 71 | 71
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

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