Development Level

Tbio 62 | 11,445
Tclin 31 | 613
Tchem 19 | 1,598
Tdark 4 | 6,588

IMPC Phenotype

preweaning lethality, complete... 11 | 979
decreased body weight 5 | 161
embryonic lethality prior to t... 5 | 278
abnormal behavior 3 | 298
abnormal bone structure 3 | 187
abnormal embryo size 3 | 220
decreased bone mineral content 3 | 151
decreased circulating HDL chol... 3 | 68
decreased circulating LDL chol... 3 | 38
decreased circulating choleste... 3 | 93
short tibia 3 | 97
abnormal retinal vasculature m... 2 | 27
cataract 2 | 92
decreased circulating serum al... 2 | 82
decreased circulating total pr... 2 | 49
decreased heart weight 2 | 27
decreased total body fat amoun... 2 | 207
enlarged heart 2 | 210
enlarged lymph nodes 2 | 37
female infertility 2 | 60
hypoactivity 2 | 132
impaired pupillary reflex 2 | 26
increased bone mineral content 2 | 108
increased circulating choleste... 2 | 66
increased startle reflex 2 | 112
male infertility 2 | 123
abnormal anxiety-related respo... 1 | 1
abnormal body wall morphology 1 | 9
abnormal bone mineralization 1 | 38
abnormal colon morphology 1 | 3
abnormal cornea morphology 1 | 31
abnormal duodenum morphology 1 | 4
abnormal eye anterior chamber ... 1 | 9
abnormal head morphology 1 | 10
abnormal lens morphology 1 | 81
abnormal optic disc morphology 1 | 10
abnormal pericardium morpholog... 1 | 26
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal social-conspecific in... 1 | 3
abnormal spleen morphology 1 | 55
abnormal tail morphology 1 | 25
abnormal vertebrae morphology 1 | 18
absent startle reflex 1 | 24
cleft palate 1 | 8
corneal opacity 1 | 32
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating fructosa... 1 | 30
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased exploration in new e... 1 | 11
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased spleen weight 1 | 10
decreased threshold for audito... 1 | 26
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
fused cornea and lens 1 | 5
hemorrhage 1 | 23
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased body length 1 | 32
increased circulating HDL chol... 1 | 80
increased circulating chloride... 1 | 41
increased circulating fructosa... 1 | 13
increased circulating sodium l... 1 | 71
increased exploration in new e... 1 | 8
increased heart rate 1 | 23
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased total body fat amoun... 1 | 134
iris synechia 1 | 3
limb grasping 1 | 41
narrow eye opening 1 | 12
no spontaneous movement 1 | 1
persistence of hyaloid vascula... 1 | 33
preweaning lethality, incomple... 1 | 499
tremors 1 | 39

Disease

Carcinoma 81 | 11,493
osteosarcoma 64 | 7,950
medulloblastoma, large-cell 60 | 6,241
Cancer 57 | 2,499
glioblastoma 57 | 5,792
lung cancer 52 | 4,740
psoriasis 52 | 6,694
ovarian cancer 50 | 8,520
ependymoma 48 | 4,679
atypical teratoid / rhabdoid tumor 47 | 5,112
malignant mesothelioma 45 | 3,232
Breast cancer 43 | 3,578
Astrocytoma, Pilocytic 40 | 3,081
group 3 medulloblastoma 40 | 4,104
Schizophrenia 38 | 1,160
adult high grade glioma 38 | 3,801
oligodendroglioma 38 | 2,850
Kidney cancer 36 | 2,613
invasive ductal carcinoma 34 | 2,951
non-small cell lung cancer 33 | 2,890
lung adenocarcinoma 32 | 2,716
lung carcinoma 31 | 2,843
interstitial cystitis 30 | 2,312
astrocytic glioma 28 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,291
primitive neuroectodermal tumor 27 | 3,035
Bipolar Disorder 24 | 666
cystic fibrosis 24 | 1,696
pancreatic cancer 24 | 2,398
subependymal giant cell astrocytoma 24 | 2,287
pituitary cancer 23 | 1,972
tuberculosis 23 | 2,010
Rheumatoid arthritis 21 | 1,191
diabetes mellitus 21 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,955
ulcerative colitis 21 | 1,819
breast carcinoma 20 | 1,638
ductal carcinoma in situ 20 | 1,745
Autosomal recessive predisposition 18 | 1,442
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,989
Depressive disorder 17 | 409
colon cancer 17 | 1,478
Pick disease 16 | 1,894
group 4 medulloblastoma 16 | 1,855
Major Depressive Disorder 15 | 301
Breast Neoplasms 14 | 445
Liver Cirrhosis, Experimental 14 | 769
Mammary Neoplasms 14 | 425
astrocytoma 14 | 1,146
Epilepsy 13 | 792
Mental Depression 13 | 333
Parkinson's disease 13 | 392
Skin cancer 13 | 469
Unipolar Depression 13 | 250
cutaneous lupus erythematosus 13 | 1,057
Alzheimer's disease 12 | 658
Hirschsprung's disease 12 | 46
Melanoma 12 | 711
adrenocortical carcinoma 12 | 1,428
Carcinoma, Hepatocellular 11 | 228
Cleft Palate 11 | 271
Liver carcinoma 11 | 240
Stomach Neoplasms 11 | 300
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
spina bifida 11 | 1,074
Anemia 10 | 365
Asthma 10 | 385
Atopic dermatitis 10 | 952
Hypereosinophilic syndrome 10 | 71
Intellectual disability 10 | 1,016
Lung Neoplasms 10 | 232
Prostatic Neoplasms 10 | 495
Renal Cell Carcinoma 10 | 214
Seizures 10 | 596
Thrombocytopenia 10 | 197
primary pancreatic ductal adenocarcinoma 10 | 1,109
Alcoholic Intoxication, Chronic 9 | 289
Cleft Lip 9 | 141
Down syndrome 9 | 499
Downward slant of palpebral fissure 9 | 158
Liver cancer 9 | 604
Multiple myeloma 9 | 1,332
Polycystic ovary syndrome 9 | 360
Pulmonary Fibrosis 9 | 106
Toxic encephalopathy 9 | 141
non-small cell lung carcinoma 9 | 317
Autistic Disorder 8 | 364
Heart disease 8 | 306
Hepatomegaly 8 | 285
Liver Cirrhosis 8 | 181
Mesothelioma, Malignant 8 | 105
Myocardial Ischemia 8 | 169
Neoplasm Invasiveness 8 | 161
fibroadenoma 8 | 559
hepatocellular carcinoma 8 | 547
mucosa-associated lymphoid tissue lymphoma 8 | 484
pancreatic carcinoma 8 | 562
primary Sjogren syndrome 8 | 735
Immune system cancer 7 | 140
esophageal adenocarcinoma 7 | 737

Tissue

Endocrine System 114 | 18,159
Blood and immune system 111 | 16,909
Digestive Tract 111 | 17,369
Skin and soft tissues 111 | 17,230
Female tissues 110 | 17,400
Liver and Pancreas 110 | 16,750
Male tissues 110 | 17,142
Nervous System 109 | 16,725
Urinary Tract 108 | 16,678
Respiratory system 106 | 16,393
Cardiovascular System 99 | 15,192

Target Family

Non-IDG 82 | 12,091
Kinase 23 | 634
Enzyme 5 | 4,145
Ion Channel 5 | 344
GPCR 1 | 408

GO Function

Ras guanyl-nucleotide exchange... 116 | 116
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pro-neuregulin-4, membrane-bound isoform NRG4 Tbio Non-IDG -1.33564 24.6 137
Fibroblast growth factor 19 FGF19 Tbio Non-IDG -2.54882 334.2 305
Calcium/calmodulin-dependent protein kinase type II subunit gamma CAMK2G Tchem Kinase -0.94556 7.03 308
Calcium/calmodulin-dependent protein kinase type II subunit beta CAMK2B Tchem Kinase -1.14550 13.6 344
Ras-GEF domain-containing family member 1A RASGEF1A Tdark Non-IDG -0.56596 3.21 50
Rap guanine nucleotide exchange factor 2 RAPGEF2 Tbio Non-IDG -1.41107 29.0 79
Neurturin NRTN Tbio Non-IDG -2.21792 170.4 331
Fibroblast growth factor receptor substrate 3 FRS3 Tbio Non-IDG -0.92119 9.61 156
Linker for activation of T-cells family member 1 LAT Tbio Non-IDG -2.16291 169.4 667
SHC-transforming protein 2 SHC2 Tbio Non-IDG -2.47843 293.4 113