Development Level

Tbio 11 | 11,445
Tchem 1 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal embryo size 2 | 220
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
abnormal body wall morphology 1 | 9
abnormal craniofacial morpholo... 1 | 33
abnormal embryo turning 1 | 31
abnormal facial morphology 1 | 17
abnormal limb bud morphology 1 | 17
abnormal limb morphology 1 | 13
anophthalmia 1 | 33
cleft palate 1 | 8
decreased body weight 1 | 161
decreased fasted circulating g... 1 | 65
decreased lean body mass 1 | 135
decreased total body fat amoun... 1 | 207
edema 1 | 59
embryonic growth retardation 1 | 106
facial cleft 1 | 3
increased circulating bilirubi... 1 | 16
increased mean corpuscular hem... 1 | 96
polydactyly 1 | 7
thrombocytosis 1 | 27

Disease

Carcinoma 11 | 11,493
osteosarcoma 7 | 7,950
ovarian cancer 7 | 8,520
astrocytic glioma 6 | 2,597
atypical teratoid / rhabdoid tumor 6 | 5,112
ependymoma 6 | 4,679
diabetes mellitus 4 | 1,728
medulloblastoma, large-cell 4 | 6,241
oligodendroglioma 4 | 2,850
Breast cancer 3 | 3,578
Kidney cancer 3 | 2,613
glioblastoma 3 | 5,792
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
lung carcinoma 3 | 2,843
psoriasis 3 | 6,694
subependymal giant cell astrocytoma 3 | 2,287
Astrocytoma, Pilocytic 2 | 3,081
Cancer 2 | 2,499
Hypertension 2 | 396
Liver Cirrhosis, Experimental 2 | 769
Obesity 2 | 678
acute quadriplegic myopathy 2 | 1,158
adult high grade glioma 2 | 3,801
group 3 medulloblastoma 2 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
juvenile dermatomyositis 2 | 1,187
lung cancer 2 | 4,740
pancreatic cancer 2 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
primitive neuroectodermal tumor 2 | 3,035
spina bifida 2 | 1,074
tuberculosis 2 | 2,010
Abnormality of oral frenula 1 | 7
Absent/hypoplastic paranasal sinuses 1 | 5
Accessory carpal bone 1 | 2
Antegonial notching of mandible 1 | 2
Anterior concavity of thoracic vertebrae 1 | 1
Anteriorly placed odontoid process 1 | 1
Broad distal phalanx (thumb) 1 | 3
Broad phalanges of the hand 1 | 2
Camptodactyly of toe 1 | 4
Capitate-hamate fusion 1 | 5
Cardiac valvular dysplasia, X-linked 1 | 1
Cerebral Infarction 1 | 10
Congenital Short Bowel Syndrome 1 | 2
Cor pulmonale 1 | 6
Craniofacial hyperostosis 1 | 11
Decreased pneumatization of frontal sinus 1 | 6
Delayed closure of the soft spot on the skull 1 | 11
Delayed coalescence of calcaneal ossification centers 1 | 2
Enlargement of craniofacial bones 1 | 11
Fibular aplasia 1 | 6
Flexion contracture - wrist 1 | 6
Frontometaphyseal dysplasia 1 | 2
Fused cervical vertebrae 1 | 5
Hirsute forehead 1 | 1
Hyperplasia of forehead 1 | 3
Hypertrophy of craniofacial bones 1 | 11
Hypertrophy of forehead 1 | 3
Hypoplastic frontal sinuses 1 | 6
Hypoplastic scapulae 1 | 14
Hypotrophic frontal sinus 1 | 6
Increased density of long bone diaphyses 1 | 1
Increased mean platelet volume 1 | 6
Intestinal pseudo-obstruction 1 | 12
Irregular metacarpals 1 | 2
Large forehead 1 | 3
Late closure of anterior fontanel 1 | 11
Lipoatrophy 1 | 19
Localized Skin Lesion 1 | 1
Long fingers 1 | 9
Long foot 1 | 8
Long metacarpals 1 | 2
Long neck 1 | 3
Melnick-Needles Syndrome 1 | 1
Missing all teeth 1 | 3
Multiple buried teeth 1 | 2
Multiple impacted teeth 1 | 2
Noisy respiration 1 | 5
Opitz-Kaveggia Syndrome 1 | 3
Oto-Palato-digital syndrome type 1 1 | 2
Phyllodes Tumor 1 | 5
Pierre Robin Syndrome 1 | 11
Posterior vertebral hypoplasia 1 | 3
Radial bowing 1 | 13
Second finger clinodactyly 1 | 5
Senile entropion 1 | 1
Short 5th metacarpal 1 | 5
Short distal phalanx of hallux 1 | 2
Short hallux 1 | 16
Spondylolysis 1 | 14
Stenosis of ureter 1 | 2
Stridor 1 | 5
Stroke, Ischemic 1 | 3
Synostosis of carpal bones 1 | 9
Thick craniofacial bones 1 | 11
Thick skull base 1 | 2
Tricuspid Valve Prolapse 1 | 3
VALVULAR ABNORMALITY 1 | 12

Tissue

Blood and immune system 12 | 16,909
Cardiovascular System 12 | 15,192
Digestive Tract 12 | 17,369
Endocrine System 12 | 18,159
Female tissues 12 | 17,400
Liver and Pancreas 12 | 16,750
Male tissues 12 | 17,142
Nervous System 12 | 16,725
Respiratory system 12 | 16,393
Skin and soft tissues 12 | 17,230
Urinary Tract 12 | 16,678

Target Family

Non-IDG 9 | 12,091
Enzyme 3 | 4,145
Kinase 1 | 634

GO Function

Ral GTPase binding 13 | 13
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
PIH1 domain-containing protein 2 PIH1D2 Tdark Non-IDG 0.56 0.07 98
U6 snRNA-associated Sm-like protein LSm2 LSM2 Tbio Non-IDG -1.40226 23.0 121
Ras-related protein Rab-34 RAB34 Tbio Enzyme -1.77250 102.9 72
Exocyst complex component 4 EXOC4 Tbio Non-IDG -1.61492 39.1 121
Protein kinase C eta type PRKCH Tchem Kinase -1.79158 65.4 184
Exocyst complex component 5 EXOC5 Tbio Non-IDG -1.45220 28.7 83
Unconventional myosin-Ic MYO1C Tbio Non-IDG -1.89688 82.6 117
Exocyst complex component 2 EXOC2 Tbio Non-IDG -1.73003 48.8 86
Exocyst complex component 8 EXOC8 Tbio Non-IDG -1.20083 14.8 75
E3 ubiquitin-protein ligase NRDP1 RNF41 Tbio Enzyme -1.58988 45.0 148