Development Level

Tbio 12 | 11,445
Tchem 1 | 1,598

IMPC Phenotype

decreased circulating triglyce... 2 | 79
abnormal behavior 1 | 298
abnormal response to tactile s... 1 | 17
abnormal vibrissa morphology 1 | 25
decreased IgE level 1 | 6
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased body weight 1 | 161
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating serum al... 1 | 82
decreased grip strength 1 | 116
decreased hemoglobin content 1 | 68
decreased total body fat amoun... 1 | 207
hypoactivity 1 | 132
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating free fat... 1 | 20
increased circulating total pr... 1 | 28
increased lean body mass 1 | 172
increased mature B cell number 1 | 1

Disease

Carcinoma 13 | 11,493
Kidney cancer 10 | 2,613
medulloblastoma, large-cell 9 | 6,241
osteosarcoma 9 | 7,950
atypical teratoid / rhabdoid tumor 8 | 5,112
glioblastoma 8 | 5,792
ovarian cancer 8 | 8,520
Astrocytoma, Pilocytic 7 | 3,081
ependymoma 7 | 4,679
interstitial cystitis 7 | 2,312
Liver cancer 6 | 604
adult high grade glioma 6 | 3,801
group 3 medulloblastoma 6 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
invasive ductal carcinoma 6 | 2,951
primitive neuroectodermal tumor 6 | 3,035
subependymal giant cell astrocytoma 6 | 2,287
lung carcinoma 5 | 2,843
pancreatic cancer 5 | 2,398
Melanoma 4 | 711
ductal carcinoma in situ 4 | 1,745
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
non-small cell lung cancer 4 | 2,890
psoriasis 4 | 6,694
spina bifida 4 | 1,074
Amyotrophic lateral sclerosis 3 | 451
Breast cancer 3 | 3,578
Cancer 3 | 2,499
Endometrial cancer 3 | 311
Skin cancer 3 | 469
breast carcinoma 3 | 1,638
cystic fibrosis 3 | 1,696
esophageal adenocarcinoma 3 | 737
lung adenocarcinoma 3 | 2,716
malignant mesothelioma 3 | 3,232
oligodendroglioma 3 | 2,850
primary Sjogren syndrome 3 | 735
Pick disease 2 | 1,894
Vascular disease 2 | 319
astrocytic glioma 2 | 2,597
cutaneous lupus erythematosus 2 | 1,057
lung cancer 2 | 4,740
pediatric high grade glioma 2 | 1,064
pituitary cancer 2 | 1,972
ulcerative colitis 2 | 1,819
AMYOTROPHIC LATERAL SCLEROSIS 1 1 | 49
Adenocarcinoma of lung 1 | 142
Adult T-Cell Lymphoma/Leukemia 1 | 30
Alzheimer's disease 1 | 658
Autistic Disorder 1 | 364
Brachydactyly 1 | 156
Cardiovascular system disease 1 | 246
Chronic obstructive pulmonary disease 1 | 184
Coronary Disease 1 | 25
Dermatitis 1 | 157
Down syndrome 1 | 499
Glomerulonephritis, IGA 1 | 34
Hypertension 1 | 396
Hyperventilation 1 | 6
Hypothyroidism 1 | 122
IGA Glomerulonephritis 1 | 50
Immunologic Deficiency Syndromes 1 | 113
Large intestine cancer 1 | 126
Leukemia, Lymphocytic, Chronic, B-Cell 1 | 34
Leukemia-Lymphoma, Adult T-Cell 1 | 30
Lissencephaly 1 | 69
Liver Cirrhosis, Experimental 1 | 769
Liver disease 1 | 237
Lymphoid leukemia 1 | 160
Major Depressive Disorder 1 | 301
Mouth Neoplasms 1 | 55
Neurodegenerative disease 1 | 414
Orofacial cleft 1 | 54
Paraplegia 1 | 74
Polycystic ovary syndrome 1 | 360
Prenatal onset 1 | 139
Prostate cancer 1 | 175
Substance-Related Disorders 1 | 115
Tachycardia 1 | 43
Unipolar Depression 1 | 250
Waldenstrons macroglobulinemia 1 | 765
active Crohn's disease 1 | 922
active ulcerative colitis 1 | 764
acute quadriplegic myopathy 1 | 1,158
aldosterone-producing adenoma 1 | 665
atypical teratoid/rhabdoid tumor 1 | 357
colon cancer 1 | 1,478
cystic fibrosis and chronic rhinosinusitis 1 | 214
fibroadenoma 1 | 559
head and neck cancer 1 | 271
leukocyte-adhesion deficiency syndrome 1 | 8
medulloblastoma 1 | 720
nephrosclerosis 1 | 333
non-inflammatory breast cancer 1 | 66
pancreatic ductal adenocarcinoma liver metastasis 1 | 1,962
primary pancreatic ductal adenocarcinoma 1 | 1,109
progressive supranuclear palsy 1 | 676
sonic hedgehog group medulloblastoma 1 | 467
tuberculosis 1 | 2,010

Tissue

Blood and immune system 13 | 16,909
Cardiovascular System 13 | 15,192
Digestive Tract 13 | 17,369
Endocrine System 13 | 18,159
Female tissues 13 | 17,400
Liver and Pancreas 13 | 16,750
Male tissues 13 | 17,142
Nervous System 13 | 16,725
Respiratory system 13 | 16,393
Skin and soft tissues 13 | 17,230
Urinary Tract 13 | 16,678

Target Family

Non-IDG 12 | 12,091
Kinase 1 | 634

GO Function

Rac guanyl-nucleotide exchange... 13 | 13
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

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