Development Level

Tbio 33 | 11,651
Tchem 11 | 1,388
Tdark 2 | 6,593

Collection

Kinase: IDG Consortium (Target... 4 | 125
RFA-RM-18-021 4 | 328
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

abnormal bone structure 2 | 187
decreased bone mineral content 2 | 151
decreased circulating serum al... 2 | 82
decreased neutrophil cell numb... 2 | 42
abnormal behavior 1 | 298
abnormal coat-hair pigmentatio... 1 | 64
abnormal coping response 1 | 1
abnormal digestive system phys... 1 | 1
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating chloride... 1 | 30
decreased circulating insulin ... 1 | 76
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased threshold for audito... 1 | 26
embryonic lethality prior to t... 1 | 278
hypoactivity 1 | 132
increased blood urea nitrogen ... 1 | 48
increased caudal vertebrae num... 1 | 7
increased circulating glucose ... 1 | 24
increased circulating phosphat... 1 | 26
increased circulating thyroxin... 1 | 7
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased mean platelet volume 1 | 45
increased total body fat amoun... 1 | 134
increased vertical activity 1 | 24
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97

Disease

Carcinoma 41 | 11,493
glioblastoma 27 | 5,792
ovarian cancer 26 | 8,520
osteosarcoma 25 | 7,950
atypical teratoid / rhabdoid tumor 21 | 5,112
medulloblastoma, large-cell 19 | 6,241
adult high grade glioma 18 | 3,801
psoriasis 18 | 6,694
Astrocytoma, Pilocytic 17 | 3,081
ependymoma 16 | 4,679
Cancer 15 | 2,499
primitive neuroectodermal tumor 15 | 3,035
Breast cancer 14 | 3,578
Kidney cancer 14 | 2,613
lung cancer 14 | 4,740
Intellectual disability 13 | 1,016
group 3 medulloblastoma 13 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
lung carcinoma 12 | 2,843
oligodendroglioma 12 | 2,850
astrocytic glioma 10 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
non-small cell lung cancer 10 | 2,890
pancreatic cancer 10 | 2,398
subependymal giant cell astrocytoma 10 | 2,287
invasive ductal carcinoma 9 | 2,951
lung adenocarcinoma 9 | 2,716
malignant mesothelioma 8 | 3,232
pituitary cancer 8 | 1,972
Dull intelligence 7 | 645
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Poor school performance 7 | 645
cystic fibrosis 7 | 1,696
diabetes mellitus 7 | 1,728
interstitial cystitis 7 | 2,312
juvenile dermatomyositis 7 | 1,187
tuberculosis 7 | 2,010
Duchenne muscular dystrophy 6 | 601
Epilepsy 6 | 792
Familial hypocalciuric hypercalcemia 6 | 20
Liver Cirrhosis, Experimental 6 | 769
Liver cancer 6 | 604
Schizophrenia 6 | 1,160
primary pancreatic ductal adenocarcinoma 6 | 1,109
Hypertension 5 | 396
Seizures 5 | 596
X- linked recessive 5 | 110
astrocytoma 5 | 1,146
colon cancer 5 | 1,478
gastric carcinoma 5 | 807
group 4 medulloblastoma 5 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
3p- syndrome 4 | 21
Alzheimer's disease 4 | 658
Autosomal recessive predisposition 4 | 1,442
Cognitive delay 4 | 608
Global developmental delay 4 | 608
Mental and motor retardation 4 | 608
Neurodegenerative disease 4 | 414
Pick disease 4 | 1,894
Proteinuria 4 | 144
Rheumatoid arthritis 4 | 1,191
Short stature 4 | 531
Waldenstrons macroglobulinemia 4 | 765
active Crohn's disease 4 | 922
acute myeloid leukemia 4 | 783
acute quadriplegic myopathy 4 | 1,158
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
dermatomyositis 4 | 966
ulcerative colitis 4 | 1,819
Acquired scoliosis 3 | 281
Amyotrophic lateral sclerosis 3 | 451
Anteverted nostril 3 | 191
Atherosclerosis 3 | 291
Autistic Disorder 3 | 364
Byzanthine arch palate 3 | 194
Curvature of spine 3 | 282
Down syndrome 3 | 499
Gastroesophageal reflux disease 3 | 110
Heart disease 3 | 306
Heartburn 3 | 78
Hypercholesterolemia 3 | 44
Long philtrum 3 | 137
Muscle Spasticity 3 | 195
Parkinson's disease 3 | 392
Pectus excavatum 3 | 100
Prostatic Neoplasms 3 | 495
Short nose 3 | 132
Small nose 3 | 132
active ulcerative colitis 3 | 764
breast carcinoma 3 | 1,638
medulloblastoma 3 | 720
mucosa-associated lymphoid tissue lymphoma 3 | 484
nasopharyngeal carcinoma 3 | 1,058
pediatric high grade glioma 3 | 1,064
spina bifida 3 | 1,074
urothelial carcinoma 3 | 318

Tissue

Digestive Tract 45 | 17,369
Endocrine System 45 | 18,159
Female tissues 45 | 17,400
Liver and Pancreas 45 | 16,750
Male tissues 45 | 17,142
Skin and soft tissues 45 | 17,230
Cardiovascular System 44 | 15,192
Nervous System 44 | 16,725
Respiratory system 44 | 16,393
Blood and immune system 43 | 16,909
Urinary Tract 43 | 16,678

Target Family

Non-IDG 18 | 12,091
Enzyme 17 | 4,145
Kinase 11 | 634

GO Function

Rac GTPase binding 46 | 46
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cytoplasmic FMR1-interacting protein 1 CYFIP1 Tbio Non-IDG -1.46134 28.5 64
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
NADPH oxidase 1 NOX1 Tchem Enzyme -2.59188 397.6 233
Coronin-1C CORO1C Tbio Non-IDG -1.47050 32.6 211
SLIT-ROBO Rho GTPase-activating protein 3 SRGAP3 Tbio Enzyme -1.70089 58.5 76
Inositol polyphosphate 5-phosphatase OCRL-1 OCRL Tbio Enzyme -2.20394 172.2 226
NADPH oxidase activator 1 NOXA1 Tbio Enzyme -1.24428 16.9 95
Arfaptin-2 ARFIP2 Tbio Non-IDG -2.07883 109.5 194
Wiskott-Aldrich syndrome protein WAS Tbio Non-IDG -3.10496 1242.1 320
Cyclin-dependent kinase-like 5 CDKL5 Tchem Kinase -2.14512 140.1 195