Development Level

Tbio 105 | 11,445
Tdark 27 | 6,588
Tclin 4 | 613
Tchem 2 | 1,598

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 9 | 979
preweaning lethality, incomple... 8 | 499
decreased grip strength 5 | 116
embryonic lethality prior to t... 5 | 278
embryonic lethality prior to o... 4 | 239
abnormal behavior 3 | 298
abnormal bone structure 3 | 187
abnormal embryo size 3 | 220
decreased body weight 3 | 161
decreased bone mineral content 3 | 151
decreased circulating serum al... 3 | 82
decreased vertical activity 3 | 208
increased circulating alkaline... 3 | 122
increased mean corpuscular vol... 3 | 92
abnormal gait 2 | 69
decreased body length 2 | 101
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 68
decreased circulating choleste... 2 | 93
decreased circulating glucose ... 2 | 126
decreased circulating triglyce... 2 | 79
decreased hemoglobin content 2 | 68
decreased leukocyte cell numbe... 2 | 73
decreased startle reflex 2 | 75
decreased total body fat amoun... 2 | 207
hyperactivity 2 | 148
increased circulating amylase ... 2 | 25
increased circulating chloride... 2 | 41
increased hematocrit 2 | 46
increased mean corpuscular hem... 2 | 96
increased neutrophil cell numb... 2 | 46
increased red blood cell distr... 2 | 34
increased startle reflex 2 | 112
prolonged PR interval 2 | 15
short tibia 2 | 97
tremors 2 | 39
abnormal bone mineralization 1 | 38
abnormal coat appearance 1 | 31
abnormal coat- hair morphology 1 | 19
abnormal coat-hair pigmentatio... 1 | 64
abnormal cranium morphology 1 | 36
abnormal heart morphology 1 | 162
abnormal joint morphology 1 | 23
abnormal motor capabilities-co... 1 | 5
abnormal response to new envir... 1 | 10
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal sleep behavior 1 | 70
abnormal snout morphology 1 | 23
abnormal spinal cord morpholog... 1 | 9
abnormal spleen morphology 1 | 55
abnormal tail movements 1 | 12
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal vitreous body morphol... 1 | 10
absent startle reflex 1 | 24
cardiovascular system phenotyp... 1 | 36
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating chloride... 1 | 30
decreased circulating fructosa... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating potassiu... 1 | 20
decreased circulating total pr... 1 | 49
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased heart rate 1 | 18
decreased hematocrit 1 | 46
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased mature B cell number 1 | 7
decreased total retina thickne... 1 | 17
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
enlarged spleen 1 | 41
hydrometra 1 | 53
improved glucose tolerance 1 | 79
increased bone mineral density 1 | 72
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating free fat... 1 | 20
increased circulating phosphat... 1 | 26
increased circulating serum al... 1 | 22
increased erythrocyte cell num... 1 | 39
increased exploration in new e... 1 | 8
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
prolonged RR interval 1 | 8
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74
small testis 1 | 58
thrombocytopenia 1 | 56

Disease

Carcinoma 103 | 11,493
osteosarcoma 72 | 7,950
ovarian cancer 69 | 8,520
medulloblastoma, large-cell 49 | 6,241
glioblastoma 47 | 5,792
atypical teratoid / rhabdoid tumor 46 | 5,112
ependymoma 44 | 4,679
adult high grade glioma 32 | 3,801
psoriasis 31 | 6,694
intraductal papillary-mucinous carcinoma (IPMC) 30 | 2,989
lung cancer 30 | 4,740
Astrocytoma, Pilocytic 29 | 3,081
oligodendroglioma 29 | 2,850
lung carcinoma 28 | 2,843
Kidney cancer 27 | 2,613
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,291
Breast cancer 26 | 3,578
astrocytic glioma 25 | 2,597
malignant mesothelioma 25 | 3,232
primitive neuroectodermal tumor 25 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 24 | 2,955
group 3 medulloblastoma 22 | 4,104
invasive ductal carcinoma 22 | 2,951
Pick disease 21 | 1,894
group 4 medulloblastoma 20 | 1,855
non-small cell lung cancer 20 | 2,890
subependymal giant cell astrocytoma 19 | 2,287
interstitial cystitis 17 | 2,312
pancreatic cancer 17 | 2,398
tuberculosis 15 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
ductal carcinoma in situ 13 | 1,745
spina bifida 13 | 1,074
Cancer 12 | 2,499
adrenocortical carcinoma 12 | 1,428
astrocytoma 12 | 1,146
diabetes mellitus 11 | 1,728
lung adenocarcinoma 11 | 2,716
pediatric high grade glioma 11 | 1,064
pituitary cancer 11 | 1,972
Schizophrenia 10 | 1,160
acute quadriplegic myopathy 10 | 1,158
gastric carcinoma 10 | 807
juvenile dermatomyositis 10 | 1,187
Parkinson's disease 9 | 392
Rheumatoid arthritis 9 | 1,191
non primary Sjogren syndrome sicca 9 | 891
Alzheimer's disease 8 | 658
Autosomal recessive predisposition 8 | 1,442
active Crohn's disease 8 | 922
nasopharyngeal carcinoma 8 | 1,058
Amyotrophic lateral sclerosis 7 | 451
Intellectual disability 7 | 1,016
Multiple myeloma 7 | 1,332
active ulcerative colitis 7 | 764
acute myeloid leukemia 7 | 783
colon cancer 7 | 1,478
dermatomyositis 7 | 966
fibroadenoma 7 | 559
progressive supranuclear palsy 7 | 676
sonic hedgehog group medulloblastoma 7 | 467
ulcerative colitis 7 | 1,819
Griscelli syndrome 6 | 24
Liver Cirrhosis, Experimental 6 | 769
Liver cancer 6 | 604
Neurodegenerative disease 6 | 414
Waldenstrons macroglobulinemia 6 | 765
breast carcinoma 6 | 1,638
cystic fibrosis 6 | 1,696
esophageal adenocarcinoma 6 | 737
Dull intelligence 5 | 645
Gaucher disease type 1 5 | 180
Hermansky-Pudlak syndrome 5 | 42
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Microcephaly 5 | 166
Oculocerebrorenal syndrome 5 | 29
Poor school performance 5 | 645
Warburg micro syndrome 5 | 18
Abnormality of retinal pigmentation 4 | 111
Atopic dermatitis 4 | 952
Cognitive delay 4 | 608
Depressive disorder 4 | 409
Down syndrome 4 | 499
Global developmental delay 4 | 608
Mental Depression 4 | 333
Mental and motor retardation 4 | 608
Muscle hypotonia 4 | 571
Neuropathy 4 | 261
Oculocutaneous albinism 4 | 29
Osteoporosis 4 | 363
Paget's disease of bone 4 | 36
Retinal pigment epithelial abnormality 4 | 111
aldosterone-producing adenoma 4 | 665
cutaneous lupus erythematosus 4 | 1,057
mucosa-associated lymphoid tissue lymphoma 4 | 484
posterior fossa group B ependymoma 4 | 416
primary pancreatic ductal adenocarcinoma 4 | 1,109
tuberculosis and treatment for 3 months 4 | 179

Tissue

Endocrine System 138 | 18,159
Digestive Tract 133 | 17,369
Skin and soft tissues 133 | 17,230
Urinary Tract 133 | 16,678
Female tissues 132 | 17,400
Liver and Pancreas 132 | 16,750
Blood and immune system 131 | 16,909
Male tissues 131 | 17,142
Respiratory system 130 | 16,393
Nervous System 128 | 16,725
Cardiovascular System 124 | 15,192

Target Family

Non-IDG 115 | 12,091
Enzyme 19 | 4,145
Kinase 2 | 634
Epigenetic 1 | 242
Transporter 1 | 473

GO Function

Rab GTPase binding 138 | 138
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Rab GTPase-activating protein 1 RABGAP1 Tbio Enzyme -0.72004 3.69 184
Rab11 family-interacting protein 5 RAB11FIP5 Tbio Non-IDG -1.52843 34.5 62
TBC1 domain family member 2A TBC1D2 Tbio Non-IDG -1.28188 18.5 80
TBC1 domain family member 10A TBC1D10A Tbio Non-IDG -0.65759 0.00000 99
BICD family-like cargo adapter 1 BICDL1 Tdark Non-IDG -0.04139 0.95 14
Regulating synaptic membrane exocytosis protein 2 RIMS2 Tbio Non-IDG -1.64578 42.7 159
TBC1 domain family member 3F TBC1D3F Tdark Non-IDG 0.00000 0
Synaptotagmin-like protein 2 SYTL2 Tbio Non-IDG -1.27949 19.5 60
TBC1 domain family member 13 TBC1D13 Tdark Non-IDG -0.10266 1.34 92
Syntaxin-binding protein 5-like STXBP5L Tbio Non-IDG -0.71494 6.16 5