Development Level

Tdark 10 | 6,588
Tbio 1 | 11,445
Tchem 1 | 1,598

Disease

Abnormal blistering of the skin 1 | 54
Abnormality of female internal genitalia 1 | 13
Abnormality of the fingernails 1 | 51
Abnormality of the lymphatic system 1 | 14
Abnormality of the pharynx 1 | 19
Adenocarcinoma 1 | 122
Anemia, Aplastic 1 | 7
Anorectal Malformations 1 | 8
Aplasia/Hypoplasia of the skin 1 | 16
Aplastic Anemia 1 | 21
Aplastic anemia, idiopathic 1 | 4
Atrophic condition of skin 1 | 25
Basal cell carcinoma 1 | 54
Blister of skin 1 | 54
Bone marrow hypocellularity 1 | 20
Brain cancer 1 | 30
Bronchioloalveolar Adenocarcinoma 1 | 14
Carcinoma, Basal Cell 1 | 28
Carcinoma, Non-Small-Cell Lung 1 | 107
Cholangiocarcinoma 1 | 35
Clear cell sarcoma of kidney 1 | 6
Cri-Du-Chat syndrome 1 | 16
DYSKERATOSIS CONGENITA, AUTOSOMAL DOMINANT 1 | 2
DYSKERATOSIS CONGENITA, AUTOSOMAL DOMINANT 2 1 | 1
Dental caries 1 | 164
Dry skin 1 | 75
Dyskeratosis congenita 1 | 24
Dyskeratosis congenita autosomal dominant 1 | 3
Dyskeratosis congenita autosomal recessive 1 1 | 3
Dyspnea on exertion 1 | 24
Early tooth exfoliation 1 | 17
Esophageal Stenosis 1 | 15
Esophagitis 1 | 35
Excessive wrinkled skin 1 | 16
Freckles 1 | 33
Generalized hyperpigmentation 1 | 22
Generalized hypopigmentation of hair 1 | 5
Gingival Diseases 1 | 19
Glioma 1 | 74
Globulin gamma serum plasma increased result 1 | 9
HOYERAAL-HREIDARSSON SYNDROME 1 | 6
Hair shaft abnormalities 1 | 30
Hereditary Melanoma 1 | 12
Hoyeraal Hreidarsson syndrome 1 | 1
Hypergammaglobulinemia 1 | 10
Hyperglobulinemia 1 | 9
Hyperpigmented macules 1 | 42
Hypodontia 1 | 81
Hypoplastic-absent toenails 1 | 11
Idiopathic pulmonary arterial hypertension 1 | 40
Idiopathic pulmonary fibrosis 1 | 23
Immunologic Deficiency Syndromes 1 | 113
Large elongated pulp chamber 1 | 14
Leukemia, Lymphoid 1 | 8
Leukemia, Myelogenous, Chronic, BCR-ABL Positive 1 | 20
Leukokeratosis 1 | 19
Leukoplakia, Oral 1 | 20
Lupus Erythematosus, Systemic 1 | 67
Lymphatic Diseases 1 | 14
Lymphoid leukemia 1 | 160
MELANOMA, CUTANEOUS MALIGNANT, 1 1 | 13
MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 9 1 | 1
Malignant glioma 1 | 26
Myeloid Leukemia, Chronic 1 | 23
Neoplasms 1 | 63
Nevus 1 | 19
Ovarian Neoplasms 1 | 102
PULMONARY FIBROSIS AND/OR BONE MARROW FAILURE, TELOMERE-RELATED, 1 1 | 1
Periodontal Diseases 1 | 21
Pitting of nails 1 | 6
Pneumonia, Interstitial 1 | 5
Premature canities 1 | 24
Premature tooth loss 1 | 17
Pulmonary Fibrosis 1 | 106
Pulmonary Fibrosis, Idiopathic 1 | 12
Pulmonary hypertension 1 | 85
Raised level of immunoglobulins NOS 1 | 9
Reticulate hyperpigmentation 1 | 5
Ridged nails 1 | 14
Rotting teeth 1 | 73
Rough bone trabeculation 1 | 11
Skin Ulcer 1 | 48
Skin bulla 1 | 54
Sparse scalp hair 1 | 42
Squamous cell carcinoma of skin 1 | 11
Taurodontism 1 | 14
Telangiectasia of the skin 1 | 39
Testicular cancer 1 | 25
Thyroid Neoplasm 1 | 37
Thyroid Neoplasms 1 | 34
Tracheoesophageal Fistula 1 | 36
Urethral Stricture 1 | 18
Xerosis 1 | 75
familial melanoma 1 | 10
gamma globulins increased 1 | 9
hair abnormalities (non-specific) 1 | 30
hypopigmented skin patch 1 | 59
interstitial lung disease 1 | 298
non-small cell lung carcinoma 1 | 317
ovarian neoplasm 1 | 99

Tissue

Blood and immune system 1 | 16,909
Digestive Tract 1 | 17,369
Endocrine System 1 | 18,159

Target Family

Enzyme 10 | 4,145
Non-IDG 2 | 12,091

GO Function

RNA-directed DNA polymerase ac... 12 | 12
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

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