Development Level

Tbio 42 | 11,445
Tchem 4 | 1,598
Tclin 3 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 8 | 979
abnormal embryo size 4 | 220
embryonic lethality prior to t... 3 | 278
abnormal bone mineralization 2 | 38
abnormal bone structure 2 | 187
abnormal tooth morphology 2 | 24
decreased vertical activity 2 | 208
enlarged heart 2 | 210
increased lean body mass 2 | 172
increased total body fat amoun... 2 | 134
prenatal lethality 2 | 28
abnormal behavior 1 | 298
abnormal coat appearance 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal eye anterior chamber ... 1 | 9
abnormal forebrain development 1 | 20
abnormal head morphology 1 | 10
abnormal heart left ventricle ... 1 | 16
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
abnormal ovary morphology 1 | 7
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal startle reflex 1 | 15
absent epididymis 1 | 3
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
corneal opacity 1 | 32
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased bone mineral content 1 | 151
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating triglyce... 1 | 79
decreased lean body mass 1 | 135
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
dilated heart left ventricle 1 | 11
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
increased anti-nuclear antigen... 1 | 19
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating aspartat... 1 | 15
increased circulating choleste... 1 | 66
increased circulating serum al... 1 | 22
increased circulating triglyce... 1 | 42
increased grip strength 1 | 41
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
irregularly shaped pupil 1 | 7
mammalian phenotype 1 | 17
microphthalmia 1 | 26
small adrenal glands 1 | 16
small testis 1 | 58
small thymus 1 | 16
vertebral fusion 1 | 23

Disease

Carcinoma 35 | 11,493
osteosarcoma 28 | 7,950
ovarian cancer 27 | 8,520
psoriasis 26 | 6,694
medulloblastoma, large-cell 24 | 6,241
Cancer 23 | 2,499
Breast cancer 21 | 3,578
glioblastoma 20 | 5,792
lung cancer 20 | 4,740
atypical teratoid / rhabdoid tumor 18 | 5,112
malignant mesothelioma 16 | 3,232
ependymoma 15 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
group 3 medulloblastoma 12 | 4,104
interstitial cystitis 12 | 2,312
pituitary cancer 12 | 1,972
subependymal giant cell astrocytoma 12 | 2,287
invasive ductal carcinoma 11 | 2,951
lung carcinoma 11 | 2,843
primitive neuroectodermal tumor 11 | 3,035
Kidney cancer 10 | 2,613
astrocytoma 10 | 1,146
breast carcinoma 10 | 1,638
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
non-small cell lung cancer 10 | 2,890
oligodendroglioma 10 | 2,850
pancreatic cancer 10 | 2,398
Intellectual disability 9 | 1,016
Rheumatoid arthritis 9 | 1,191
adult high grade glioma 9 | 3,801
ductal carcinoma in situ 9 | 1,745
lung adenocarcinoma 9 | 2,716
Dull intelligence 8 | 645
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Poor school performance 8 | 645
Schizophrenia 8 | 1,160
group 4 medulloblastoma 8 | 1,855
ulcerative colitis 8 | 1,819
Autosomal recessive predisposition 7 | 1,442
Congenital heart disease 7 | 93
Muscle hypotonia 7 | 571
Short stature 7 | 531
diabetes mellitus 7 | 1,728
pediatric high grade glioma 7 | 1,064
Anemia 6 | 365
Bilateral fifth finger clinodactyly 6 | 110
Bipolar Disorder 6 | 666
Brachydactyly 6 | 156
Craniofacial Abnormalities 6 | 151
Cryptorchidism 6 | 296
Curvature of little finger 6 | 110
Down syndrome 6 | 499
Immune system cancer 6 | 140
Multiple myeloma 6 | 1,332
Osteoporosis 6 | 363
Prostatic Neoplasms 6 | 495
adrenocortical carcinoma 6 | 1,428
astrocytic glioma 6 | 2,597
colon cancer 6 | 1,478
cystic fibrosis 6 | 1,696
spina bifida 6 | 1,074
tuberculosis 6 | 2,010
Astrocytoma, Pilocytic 5 | 3,081
Atopic dermatitis 5 | 952
Breast Neoplasms 5 | 445
Cognitive delay 5 | 608
Colorectal Neoplasms 5 | 243
Delayed Puberty 5 | 97
Endometrial cancer 5 | 311
Endometriosis 5 | 540
Fetal Growth Retardation 5 | 189
Global developmental delay 5 | 608
Infant, Small for Gestational Age 5 | 176
Intrauterine retardation 5 | 176
Mammary Neoplasms 5 | 425
Mental and motor retardation 5 | 608
Penile hypospadias 5 | 106
Pituitary hypoplasia 5 | 23
Polycystic ovary syndrome 5 | 360
Skin cancer 5 | 469
Stomach Neoplasms 5 | 300
Vascular disease 5 | 319
Ventricular Septal Defects 5 | 119
gastric carcinoma 5 | 807
primary pancreatic ductal adenocarcinoma 5 | 1,109
Alzheimer's disease 4 | 658
Broad flat nasal bridge 4 | 236
Epilepsy 4 | 792
Heart disease 4 | 306
Male infertility 4 | 206
Nasal bridge wide 4 | 236
Pick disease 4 | 1,894
Seizures 4 | 596
Strabismus 4 | 270
active ulcerative colitis 4 | 764
cutaneous lupus erythematosus 4 | 1,057
fibroadenoma 4 | 559

Tissue

Endocrine System 49 | 18,159
Liver and Pancreas 47 | 16,750
Digestive Tract 46 | 17,369
Female tissues 46 | 17,400
Skin and soft tissues 46 | 17,230
Blood and immune system 45 | 16,909
Male tissues 45 | 17,142
Urinary Tract 45 | 16,678
Nervous System 44 | 16,725
Respiratory system 43 | 16,393
Cardiovascular System 42 | 15,192

Target Family

Transcription Factor 37 | 1,400
Non-IDG 7 | 12,091
Enzyme 2 | 4,145
Epigenetic 2 | 242
Kinase 1 | 634
Nuclear Receptor 1 | 48

GO Function

RNA polymerase II transcriptio... 50 | 50
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
X-box-binding protein 1 XBP1 Tchem Transcription Factor -2.90444 780.2 514
T-box transcription factor TBX6 TBX6 Tbio Transcription Factor -1.78720 63.0 315
Transcription factor PU.1 SPI1 Tbio Transcription Factor -3.05079 1139.0 397
Zinc finger protein ZFPM2 ZFPM2 Tbio Transcription Factor -1.78912 62.9 93
Zinc finger transcription factor Trps1 TRPS1 Tbio Transcription Factor -1.98756 107.0 69
Krueppel-like factor 4 KLF4 Tbio Transcription Factor -2.89447 774.1 686
T-box transcription factor TBX3 TBX3 Tbio Transcription Factor -2.42253 255.6 328
Brachyury protein TBXT Tbio Transcription Factor -2.24737 158.4 337
Dapper homolog 1 DACT1 Tbio Non-IDG -1.86707 79.6 106
Transcription factor GATA-5 GATA5 Tbio Transcription Factor -1.95925 86.1 183