Development Level

Tbio 125 | 11,651
Tdark 42 | 6,593
Tchem 7 | 1,388

IMPC Phenotype

preweaning lethality, complete... 11 | 979
abnormal bone structure 5 | 187
abnormal seminal vesicle morph... 4 | 114
preweaning lethality, incomple... 4 | 499
small superior vagus ganglion 4 | 74
abnormal embryo size 3 | 220
abnormal heart morphology 3 | 162
decreased circulating triglyce... 3 | 79
embryonic lethality prior to t... 3 | 278
enlarged heart 3 | 210
hydrometra 3 | 53
increased monocyte cell number 3 | 63
prenatal lethality prior to he... 3 | 87
abnormal bone mineralization 2 | 38
abnormal eye morphology 2 | 68
abnormal forebrain development 2 | 20
abnormal neural tube closure 2 | 46
abnormal vibrissa morphology 2 | 25
decreased T cell number 2 | 15
decreased body weight 2 | 161
decreased bone mineral density 2 | 126
decreased circulating chloride... 2 | 30
decreased circulating choleste... 2 | 93
decreased circulating glucose ... 2 | 126
decreased circulating sodium l... 2 | 22
decreased lean body mass 2 | 135
decreased lymphocyte cell numb... 2 | 83
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
impaired glucose tolerance 2 | 75
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased lean body mass 2 | 172
increased mean corpuscular vol... 2 | 92
male infertility 2 | 123
abnormal coat- hair morphology 1 | 19
abnormal cornea morphology 1 | 31
abnormal epididymis morphology 1 | 42
abnormal hindbrain development 1 | 16
abnormal humerus morphology 1 | 11
abnormal locomotor behavior 1 | 24
abnormal ovary morphology 1 | 7
abnormal placenta size 1 | 20
abnormal skin coloration 1 | 25
abnormal skin morphology 1 | 50
abnormal snout morphology 1 | 23
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal thymus morphology 1 | 7
absent ovary 1 | 3
absent testes 1 | 6
athymia 1 | 2
corneal opacity 1 | 32
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased IgG1 level 1 | 8
decreased anxiety-related resp... 1 | 12
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating amylase ... 1 | 28
decreased circulating free fat... 1 | 31
decreased circulating fructosa... 1 | 30
decreased circulating glycerol... 1 | 16
decreased circulating insulin ... 1 | 76
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased mature B cell number 1 | 7
decreased red blood cell distr... 1 | 41
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged uterus 1 | 11
female infertility 1 | 60
hypoactivity 1 | 132
increased B cell number 1 | 9
increased T cell number 1 | 6
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating potassiu... 1 | 29
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased lactate dehydrogenas... 1 | 3
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased total body fat amoun... 1 | 134
pale yolk sac 1 | 25
pallor 1 | 34
small kidney 1 | 16
small spleen 1 | 19
small testis 1 | 58
small uterus 1 | 3
thick ventricular wall 1 | 7
urinary bladder obstruction 1 | 4
vertebral fusion 1 | 23

Disease

Carcinoma 107 | 11,493
ovarian cancer 74 | 8,520
psoriasis 74 | 6,694
osteosarcoma 68 | 7,950
medulloblastoma, large-cell 61 | 6,241
Cancer 52 | 2,499
lung cancer 49 | 4,740
atypical teratoid / rhabdoid tumor 46 | 5,112
glioblastoma 44 | 5,792
Breast cancer 39 | 3,578
ependymoma 37 | 4,679
group 3 medulloblastoma 37 | 4,104
malignant mesothelioma 33 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 32 | 2,989
invasive ductal carcinoma 32 | 2,951
non-small cell lung cancer 30 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 29 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 28 | 2,955
pancreatic cancer 27 | 2,398
group 4 medulloblastoma 25 | 1,855
lung adenocarcinoma 25 | 2,716
adult high grade glioma 24 | 3,801
astrocytic glioma 24 | 2,597
breast carcinoma 24 | 1,638
Kidney cancer 23 | 2,613
lung carcinoma 23 | 2,843
primitive neuroectodermal tumor 23 | 3,035
ductal carcinoma in situ 22 | 1,745
interstitial cystitis 22 | 2,312
oligodendroglioma 22 | 2,850
pituitary cancer 22 | 1,972
Astrocytoma, Pilocytic 19 | 3,081
Pick disease 18 | 1,894
diabetes mellitus 18 | 1,728
Intellectual disability 16 | 1,016
tuberculosis 16 | 2,010
Schizophrenia 14 | 1,160
cystic fibrosis 14 | 1,696
Breast Neoplasms 13 | 445
ulcerative colitis 13 | 1,819
Mammary Neoplasms 12 | 425
Multiple myeloma 12 | 1,332
Rheumatoid arthritis 12 | 1,191
acute quadriplegic myopathy 12 | 1,158
adrenocortical carcinoma 12 | 1,428
colon cancer 12 | 1,478
primary pancreatic ductal adenocarcinoma 12 | 1,109
subependymal giant cell astrocytoma 12 | 2,287
Autosomal recessive predisposition 11 | 1,442
Bipolar Disorder 11 | 666
Obesity 11 | 678
Prostatic Neoplasms 11 | 495
Strabismus 11 | 270
medulloblastoma 11 | 720
pediatric high grade glioma 11 | 1,064
Atopic dermatitis 10 | 952
Lung Neoplasms 10 | 232
Craniofacial Abnormalities 9 | 151
Dull intelligence 9 | 645
Leukemia, Myelocytic, Acute 9 | 120
Low intelligence 9 | 645
Mental Retardation 9 | 645
Mental deficiency 9 | 645
Poor school performance 9 | 645
Short stature 9 | 531
acute myeloid leukemia 9 | 783
astrocytoma 9 | 1,146
fibroadenoma 9 | 559
nasopharyngeal carcinoma 9 | 1,058
primary Sjogren syndrome 9 | 735
sonic hedgehog group medulloblastoma 9 | 467
spina bifida 9 | 1,074
Autistic Disorder 8 | 364
Carcinoma, Hepatocellular 8 | 228
Concave bridge of nose 8 | 195
Depressed nasal bridge 8 | 195
Depressed nasal root/bridge 8 | 195
Leukemia, Myeloid, Acute 8 | 105
Muscle hypotonia 8 | 571
Orbital separation excessive 8 | 244
Vascular disease 8 | 319
Waldenstrons macroglobulinemia 8 | 765
chronic rhinosinusitis 8 | 512
cutaneous lupus erythematosus 8 | 1,057
non primary Sjogren syndrome sicca 8 | 891
Bilateral fifth finger clinodactyly 7 | 110
Cognitive delay 7 | 608
Curvature of little finger 7 | 110
Endometriosis 7 | 540
Epilepsy 7 | 792
Global developmental delay 7 | 608
Mental and motor retardation 7 | 608
Polycystic ovary syndrome 7 | 360
Short nose 7 | 132
Small nose 7 | 132
Stomach Neoplasms 7 | 300
dermatomyositis 7 | 966
gastric carcinoma 7 | 807
nephrosclerosis 7 | 333
pancreatic carcinoma 7 | 562

Tissue

Endocrine System 168 | 18,159
Digestive Tract 154 | 17,369
Female tissues 154 | 17,400
Skin and soft tissues 153 | 17,230
Male tissues 152 | 17,142
Blood and immune system 151 | 16,909
Nervous System 150 | 16,725
Urinary Tract 143 | 16,678
Liver and Pancreas 142 | 16,750
Respiratory system 142 | 16,393
Cardiovascular System 122 | 15,192

Target Family

Transcription Factor 143 | 1,400
Non-IDG 29 | 12,091
Enzyme 1 | 4,145
Kinase 1 | 634

GO Function

RNA polymerase II transcriptio... 174 | 174
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
ETS-related transcription factor Elf-2 ELF2 Tbio Transcription Factor -2.04794 106.4 92
Zinc finger protein 518B ZNF518B Tdark Non-IDG -0.25756 2.11 12
snRNA-activating protein complex subunit 4 SNAPC4 Tbio Transcription Factor -0.99715 10.0 160
Zinc finger and SCAN domain-containing protein 5B ZSCAN5B Tdark Transcription Factor 0.60 0.25 67
Securin PTTG1 Tbio Non-IDG -2.42127 261.4 311
Zinc finger and SCAN domain-containing protein 5A ZSCAN5A Tdark Transcription Factor 0.60 0.42 78
Runt-related transcription factor 3 RUNX3 Tbio Transcription Factor -2.71721 536.2 438
Zinc finger and SCAN domain-containing protein 32 ZSCAN32 Tdark Transcription Factor -0.16914 1.19 82
Myocyte-specific enhancer factor 2D MEF2D Tbio Transcription Factor -1.96264 88.6 323
Neuronal PAS domain-containing protein 1 NPAS1 Tbio Transcription Factor -0.85546 7.62 136