Development Level

Tclin 2 | 613

IMPC Phenotype

decreased bone mineral content 1 | 151
decreased circulating triglyce... 1 | 79
decreased heart left ventricle... 1 | 28
decreased lean body mass 1 | 135
decreased neutrophil cell numb... 1 | 42
increased circulating alkaline... 1 | 122
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased hemoglobin content 1 | 45
increased total body fat amoun... 1 | 134
thin ventricular wall 1 | 24

Disease

Adenocarcinoma 2 | 122
Alzheimer's disease 2 | 658
Animal Mammary Neoplasms 2 | 136
Atrophic vaginitis 2 | 14
Bladder Neoplasm 2 | 112
Breast Neoplasms 2 | 445
Carcinoma 2 | 11,493
Coronary artery disease 2 | 268
Dyspareunia 2 | 12
Endometrial Neoplasms 2 | 55
Endometriosis 2 | 540
Female hypogonadism syndrome 2 | 25
Female infertility 2 | 30
Infertility 2 | 188
Infertility, Female 2 | 28
Male infertility 2 | 206
Mammary Neoplasms 2 | 425
Mammary Neoplasms, Animal 2 | 136
Mammary Neoplasms, Experimental 2 | 154
Menopausal flushing 2 | 17
Metastatic Breast Cancer Progression Post-Antiestrogen Therapy 2 | 4
Obesity 2 | 678
Osteoporosis 2 | 363
Postmenopausal osteoporosis 2 | 19
Prevention of Breast Carcinoma 2 | 5
Prostatic Intraepithelial Neoplasia 2 | 11
Prostatic Intraepithelial Neoplasias 2 | 11
Prostatic Neoplasms 2 | 495
Schizophrenia 2 | 1,160
Urinary Bladder Neoplasms 2 | 114
Vascular disease 2 | 319
astrocytoma 2 | 1,146
lung cancer 2 | 4,740
ovarian cancer 2 | 8,520
psoriasis 2 | 6,694
Abdominal pain, episodic 1 | 9
Absence of pubertal development 1 | 17
Absence of secondary sex characteristics 1 | 22
Acanthosis Nigricans 1 | 27
Acne 1 | 52
Acquired metabolic disease 1 | 336
Breast disease 1 | 7
Breast fibroadenoma 1 | 8
Carcinoma of female breast 1 | 20
Carcinoma, Transitional Cell 1 | 32
Carcinosarcoma 1 | 7
Cardiac Arrhythmia 1 | 103
Chemotherapy-induced nausea and vomiting 1 | 16
Colorectal Neoplasms 1 | 243
Colorectal cancer 1 | 25
Congenital hypoplasia of breast 1 | 25
Coronary Arteriosclerosis 1 | 6
Coronary Disease 1 | 25
Coronary heart disease 1 | 16
Delayed epiphyseal ossification 1 | 10
Delayed maturation of end part of long bone 1 | 10
Disease Models, Animal 1 | 155
ESTROGEN RESISTANCE 1 | 2
Elevated gonadotropins 1 | 15
Elevated tissue non-specific alkaline phosphatase 1 | 1
Enlarged polycystic ovaries 1 | 10
Female Urogenital Diseases 1 | 18
Feminization 1 | 1
Fetal overgrowth 1 | 16
Fibroid Tumor 1 | 6
Generalized osteopenia 1 | 99
Generalized overgrowth 1 | 16
Glomerulonephritis 1 | 46
Hyperinsulinism 1 | 133
Idiopathic scoliosis 1 | 31
Impaired glucose tolerance 1 | 28
Infantile uterus 1 | 23
Leiomyoma 1 | 32
Leiomyosarcoma 1 | 24
Lobular neoplasia 1 | 15
Lymphangioleiomyomatosis 1 | 16
MIGRAINE WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 1 1 | 3
Marijuana Abuse 1 | 31
Marked delay in bone age 1 | 1
Mesothelioma 1 | 38
Metabolic Bone Disorder 1 | 11
Metastatic Breast Carcinoma 1 | 21
Metastatic Prostate Carcinoma 1 | 18
Migraine Disorders 1 | 76
Musculoskeletal Pain 1 | 3
Myocardial Infarction 1 | 151
Neoplasm Metastasis 1 | 168
Neoplasm Recurrence, Local 1 | 37
Neoplastic Cell Transformation 1 | 89
Oligospermia 1 | 36
Osteopenia 1 | 99
Overgrowth 1 | 16
Plaque build-up in arteries supplying blood to heart 1 | 6
Prevention of Post-Operative Nausea and Vomiting 1 | 14
Primary physiologic amenorrhea 1 | 55
Psychoses, Substance-Induced 1 | 17
Retinoblastoma 1 | 19
Shared Paranoid Disorder 1 | 5
Uterine fibroid 1 | 28
intermittent abdominal pain 1 | 9

Tissue

Blood and immune system 2 | 16,909
Cardiovascular System 2 | 15,192
Digestive Tract 2 | 17,369
Endocrine System 2 | 18,159
Female tissues 2 | 17,400
Liver and Pancreas 2 | 16,750
Male tissues 2 | 17,142
Nervous System 2 | 16,725
Respiratory system 2 | 16,393
Skin and soft tissues 2 | 17,230
Urinary Tract 2 | 16,678

Target Family

Nuclear Receptor 2 | 48

GO Function

RNA polymerase II transcriptio... 2 | 2
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Estrogen receptor beta ESR2 Tclin Nuclear Receptor -3.57388 3765.2 1096
Estrogen receptor ESR1 Tclin Nuclear Receptor -4.00480 8421.6 2610