Development Level

Tbio 25 | 11,445
Tclin 2 | 613
Tchem 1 | 1,598

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal lens morphology 1 | 81
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased body weight 1 | 161
decreased caudal vertebrae num... 1 | 53
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased mean corpuscular hem... 1 | 50
decreased total body fat amoun... 1 | 207
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased hemoglobin content 1 | 45

Disease

Carcinoma 19 | 11,493
osteosarcoma 17 | 7,950
ovarian cancer 17 | 8,520
psoriasis 13 | 6,694
lung cancer 11 | 4,740
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
medulloblastoma, large-cell 10 | 6,241
group 3 medulloblastoma 9 | 4,104
Breast cancer 8 | 3,578
Cancer 8 | 2,499
astrocytoma 8 | 1,146
atypical teratoid / rhabdoid tumor 8 | 5,112
glioblastoma 8 | 5,792
Waldenstrons macroglobulinemia 7 | 765
astrocytic glioma 7 | 2,597
ependymoma 7 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
lung carcinoma 7 | 2,843
oligodendroglioma 7 | 2,850
primitive neuroectodermal tumor 7 | 3,035
tuberculosis 7 | 2,010
Kidney cancer 6 | 2,613
Multiple myeloma 6 | 1,332
Strabismus 6 | 270
group 4 medulloblastoma 6 | 1,855
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
invasive ductal carcinoma 6 | 2,951
pituitary cancer 6 | 1,972
Astrocytoma, Pilocytic 5 | 3,081
Bilateral fifth finger clinodactyly 5 | 110
Curvature of little finger 5 | 110
Pick disease 5 | 1,894
Short stature 5 | 531
Brachydactyly 4 | 156
Cognitive delay 4 | 608
Epilepsy 4 | 792
Fetal Growth Retardation 4 | 189
Global developmental delay 4 | 608
Infant, Small for Gestational Age 4 | 176
Intellectual disability 4 | 1,016
Intrauterine retardation 4 | 176
Mental and motor retardation 4 | 608
Orbital separation excessive 4 | 244
Seizures 4 | 596
Small head 4 | 374
dermatomyositis 4 | 966
ductal carcinoma in situ 4 | 1,745
juvenile dermatomyositis 4 | 1,187
subependymal giant cell astrocytoma 4 | 2,287
Abnormally small eyeball 3 | 97
Acquired metabolic disease 3 | 336
Agenesis of corpus callosum 3 | 83
Alzheimer's disease 3 | 658
Autosomal recessive predisposition 3 | 1,442
Bowed and upward slanting eyebrows 3 | 41
Broad flat nasal bridge 3 | 236
Cleft Palate 3 | 271
Congenital Epicanthus 3 | 177
Craniofacial Abnormalities 3 | 151
Cryptorchidism 3 | 296
Decreased size of eyeball 3 | 97
Depressed nasal ridge 3 | 51
Downward slant of palpebral fissure 3 | 158
Dull intelligence 3 | 645
Enophthalmos 3 | 75
Glaucoma 3 | 239
Hypoplastic mandible condyle 3 | 275
Low Birth Weights 3 | 69
Low intelligence 3 | 645
Mandibular hypoplasia 3 | 275
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Micrognathism 3 | 275
Microphthalmos 3 | 100
Nasal bridge wide 3 | 236
Nystagmus 3 | 317
Obesity 3 | 678
Poor school performance 3 | 645
Rheumatoid arthritis 3 | 1,191
Schizophrenia 3 | 1,160
Small for gestational age (disorder) 3 | 69
Sunken eyes 3 | 63
Thick, flared eyebrows 3 | 41
Uranostaphyloschisis 3 | 167
acute myeloid leukemia 3 | 783
colon cancer 3 | 1,478
cystic fibrosis 3 | 1,696
esophageal adenocarcinoma 3 | 737
lung adenocarcinoma 3 | 2,716
malignant mesothelioma 3 | 3,232
non-small cell lung cancer 3 | 2,890
pancreatic cancer 3 | 2,398
pediatric high grade glioma 3 | 1,064
Curvature of spine 2 | 282
Delayed bone age 2 | 136
Failure to gain weight 2 | 365
Polycystic ovary syndrome 2 | 360
Syndactyly of the toes 2 | 45
Thin lips 2 | 49
Ventricular Septal Defects 2 | 119

Tissue

Digestive Tract 27 | 17,369
Endocrine System 27 | 18,159
Female tissues 27 | 17,400
Blood and immune system 26 | 16,909
Male tissues 26 | 17,142
Nervous System 26 | 16,725
Respiratory system 26 | 16,393
Skin and soft tissues 26 | 17,230
Urinary Tract 26 | 16,678
Cardiovascular System 25 | 15,192
Liver and Pancreas 25 | 16,750

Target Family

Non-IDG 12 | 12,091
Transcription Factor 9 | 1,400
Epigenetic 4 | 242
Enzyme 3 | 4,145

GO Function

RNA polymerase II transcriptio... 28 | 28
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Unconventional prefoldin RPB5 interactor 1 URI1 Tbio Enzyme -2.15409 134.8 150
PHD finger protein 12 PHF12 Tbio Epigenetic -2.57717 385.3 70
DNA endonuclease RBBP8 RBBP8 Tbio Enzyme -2.17933 148.4 308
Transcription factor SOX-3 SOX3 Tbio Transcription Factor -2.23686 175.4 207
E3 SUMO-protein ligase ZNF451 ZNF451 Tbio Transcription Factor -2.42090 254.4 71
Heat shock 70 kDa protein 1A HSPA1B Tchem Non-IDG -3.10995 0.00000 1174
T-box transcription factor TBX15 TBX15 Tbio Transcription Factor -1.29899 21.5 123
Hepatoma-derived growth factor HDGF Tbio Epigenetic -2.08423 132.3 192
Oligodendrocyte transcription factor 3 OLIG3 Tbio Transcription Factor -0.80409 6.73 158
Paired amphipathic helix protein Sin3b SIN3B Tbio Non-IDG -1.34131 21.4 148