Development Level

Tbio 31 | 11,445
Tdark 3 | 6,588

IMPC Phenotype

preweaning lethality, complete... 4 | 979
decreased leukocyte cell numbe... 2 | 73
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal heart morphology 1 | 162
abnormal neural tube closure 1 | 46
abnormal placenta size 1 | 20
abnormal tail bud morphology 1 | 8
decreased anxiety-related resp... 1 | 12
decreased circulating calcium ... 1 | 36
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
enlarged uterus 1 | 11
hydrometra 1 | 53
increased fasted circulating g... 1 | 76
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
pale yolk sac 1 | 25
pallor 1 | 34
small superior vagus ganglion 1 | 74

Disease

osteosarcoma 26 | 7,950
Carcinoma 18 | 11,493
ovarian cancer 17 | 8,520
glioblastoma 13 | 5,792
medulloblastoma, large-cell 13 | 6,241
psoriasis 11 | 6,694
atypical teratoid / rhabdoid tumor 10 | 5,112
group 3 medulloblastoma 10 | 4,104
Kidney cancer 9 | 2,613
astrocytic glioma 9 | 2,597
ependymoma 8 | 4,679
lung cancer 8 | 4,740
oligodendroglioma 8 | 2,850
malignant mesothelioma 7 | 3,232
primitive neuroectodermal tumor 7 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
Pick disease 5 | 1,894
Congenital heart disease 4 | 93
Endometriosis 4 | 540
astrocytoma 4 | 1,146
group 4 medulloblastoma 4 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
lung adenocarcinoma 4 | 2,716
pituitary cancer 4 | 1,972
ulcerative colitis 4 | 1,819
Breast Neoplasms 3 | 445
Breast cancer 3 | 3,578
Cognitive delay 3 | 608
Feeding difficulties 3 | 127
Global developmental delay 3 | 608
Liver cancer 3 | 604
Mammary Neoplasms 3 | 425
Mental and motor retardation 3 | 608
Multiple myeloma 3 | 1,332
Rheumatoid arthritis 3 | 1,191
Schizophrenia 3 | 1,160
Tetralogy of Fallot 3 | 63
dermatomyositis 3 | 966
diabetes mellitus 3 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
pediatric high grade glioma 3 | 1,064
tuberculosis 3 | 2,010
tuberculosis and treatment for 6 months 3 | 409
Amyotrophic lateral sclerosis 2 | 451
Autosomal recessive predisposition 2 | 1,442
Broad hallux 2 | 29
Cancer 2 | 2,499
Coarse facial features 2 | 108
Constipation 2 | 181
Cryptorchidism 2 | 296
Depressive disorder 2 | 409
Discordant ventriculoarterial connection 2 | 17
Dyschezia 2 | 135
Endometrial cancer 2 | 311
Epilepsy 2 | 792
FG syndrome 2 | 16
Fatigue 2 | 182
Intellectual disability 2 | 1,016
Lymphoid leukemia 2 | 160
Melanoma 2 | 711
Mental Depression 2 | 333
Mood swings 2 | 77
Muscle Spasticity 2 | 195
Muscle hypotonia 2 | 571
Myocardial Infarction 2 | 151
Obesity 2 | 678
Ohdo syndrome 2 | 5
Right atrial isomerism 2 | 29
Seizures 2 | 596
Short stature 2 | 531
Skin cancer 2 | 469
Thickened facial skin with coarse facial features 2 | 108
Thin lips 2 | 49
Type 2 diabetes mellitus 2 | 272
Umbilical hernia 2 | 93
Ventricular Septal Defects 2 | 119
Waldenstrons macroglobulinemia 2 | 765
acute myeloid leukemia 2 | 783
colon cancer 2 | 1,478
hepatocellular carcinoma 2 | 547
interstitial cystitis 2 | 2,312
medulloblastoma 2 | 720
non primary Sjogren syndrome sicca 2 | 891
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
tuberculosis and treatment for 3 months 2 | 179
Atypical autism 1 | 26
Connective tissue cancer 1 | 10
Cornelia de Lange syndrome 1 | 21
Farber lipogranulomatosis 1 | 9
Fatigable weakness of respiratory muscles 1 | 28
Fatigable weakness of swallowing muscles 1 | 28
High pitched voice 1 | 23
Marfanoid body habitus 1 | 11
Narrow palate 1 | 20
POLYDACTYLY, POSTAXIAL 1 | 13
Pinched bridge of nose 1 | 14
Plagiocephaly 1 | 20
Stricture of anus 1 | 13
Tricuspid atresia 1 | 7
Xerostomia 1 | 42

Tissue

Blood and immune system 33 | 16,909
Cardiovascular System 33 | 15,192
Digestive Tract 33 | 17,369
Endocrine System 33 | 18,159
Female tissues 33 | 17,400
Liver and Pancreas 33 | 16,750
Male tissues 33 | 17,142
Nervous System 33 | 16,725
Skin and soft tissues 33 | 17,230
Urinary Tract 33 | 16,678
Respiratory system 32 | 16,393

Target Family

Enzyme 24 | 4,145
Non-IDG 6 | 12,091
Transcription Factor 3 | 1,400
Epigenetic 1 | 242

GO Function

RNA polymerase II transcriptio... 34 | 34
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mediator of RNA polymerase II transcription subunit 15 MED15 Tbio Enzyme -1.60315 40.6 144
Transcriptional-regulating factor 1 TRERF1 Tbio Transcription Factor -0.69436 6.18 146
RNA-binding protein 14 RBM14 Tbio Non-IDG -2.10043 124.7 168
Mediator of RNA polymerase II transcription subunit 31 MED31 Tbio Enzyme -1.19048 15.1 61
G/T mismatch-specific thymine DNA glycosylase TDG Tbio Enzyme -2.46252 297.6 225
Thyroid hormone receptor-associated protein 3 THRAP3 Tbio Non-IDG -0.87769 8.81 136
TP53-binding protein 1 TP53BP1 Tbio Epigenetic -2.69485 464.8 577
Mediator of RNA polymerase II transcription subunit 13 MED13 Tbio Enzyme -1.52250 26.0 53
CCR4-NOT transcription complex subunit 2 CNOT2 Tbio Non-IDG -2.83887 627.5 303
ATP-dependent RNA helicase A DHX9 Tbio Enzyme -2.85807 734.3 204