Development Level

Tbio 24 | 11,445
Tclin 3 | 613
Tchem 2 | 1,598

IMPC Phenotype

preweaning lethality, complete... 9 | 979
decreased bone mineral density 4 | 126
increased total body fat amoun... 3 | 134
abnormal behavior 2 | 298
decreased lean body mass 2 | 135
embryonic lethality prior to o... 2 | 239
increased hemoglobin content 2 | 45
preweaning lethality, incomple... 2 | 499
thrombocytopenia 2 | 56
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal gait 1 | 69
abnormal heart left ventricle ... 1 | 16
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased grip strength 1 | 116
decreased heart rate variabili... 1 | 13
decreased heart weight 1 | 27
decreased lumbar vertebrae num... 1 | 2
decreased respiratory quotient 1 | 16
decreased sacral vertebrae num... 1 | 1
decreased spleen weight 1 | 10
decreased total body fat amoun... 1 | 207
embryonic lethality prior to t... 1 | 278
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased body temperature 1 | 9
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased lumbar vertebrae num... 1 | 1
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased prepulse inhibition 1 | 32
increased sacral vertebrae num... 1 | 1
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
short tibia 1 | 97

Disease

Carcinoma 23 | 11,493
ovarian cancer 21 | 8,520
psoriasis 14 | 6,694
Intellectual disability 12 | 1,016
Obesity 12 | 678
osteosarcoma 12 | 7,950
Cancer 11 | 2,499
medulloblastoma, large-cell 11 | 6,241
atypical teratoid / rhabdoid tumor 9 | 5,112
ependymoma 9 | 4,679
glioblastoma 9 | 5,792
Bardet-Biedl syndrome 8 | 51
Bardet-Biedl syndrome 1 8 | 22
Ciliopathy 8 | 71
Dull intelligence 8 | 645
Low intelligence 8 | 645
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Poor school performance 8 | 645
Short stature 8 | 531
diabetes mellitus 8 | 1,728
group 3 medulloblastoma 8 | 4,104
primitive neuroectodermal tumor 8 | 3,035
Autosomal recessive predisposition 7 | 1,442
Cone dystrophy 7 | 71
Polydactyly 7 | 107
Schizophrenia 7 | 1,160
lung cancer 7 | 4,740
Brachydactyly 6 | 156
Cognitive delay 6 | 608
Congenital hypoplasia of penis 6 | 176
Endometriosis 6 | 540
Fundus dystrophy 6 | 83
Global developmental delay 6 | 608
Hypertensive disease 6 | 292
Hypogonadism 6 | 173
Mental and motor retardation 6 | 608
Nystagmus 6 | 317
Pick disease 6 | 1,894
Retinitis Pigmentosa 6 | 226
Rheumatoid arthritis 6 | 1,191
lung carcinoma 6 | 2,843
malignant mesothelioma 6 | 3,232
Asthma 5 | 385
Astrocytoma, Pilocytic 5 | 3,081
Breast cancer 5 | 3,578
Congenital hypoplasia of ovary 5 | 30
Electroretinogram abnormal 5 | 95
Hypoplastic ovary 5 | 30
Increase in blood pressure 5 | 119
Kidney cancer 5 | 2,613
Multicystic Dysplastic Kidney 5 | 52
Multiple myeloma 5 | 1,332
Retinal Degeneration 5 | 106
Strabismus 5 | 270
Ulnar polydactyly of fingers 5 | 47
astrocytoma 5 | 1,146
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
oligodendroglioma 5 | 2,850
Cryptorchidism 4 | 296
Delayed speech and language development 4 | 112
Heart disease 4 | 306
High, narrow palate 4 | 32
Hyperglycemia 4 | 137
Language Delay 4 | 112
Radially deviated fingers 4 | 38
Small genitalia 4 | 13
Speech Delay 4 | 112
Speech impairment 4 | 112
astrocytic glioma 4 | 2,597
group 4 medulloblastoma 4 | 1,855
lung adenocarcinoma 4 | 2,716
medulloblastoma 4 | 720
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
pituitary cancer 4 | 1,972
subependymal giant cell astrocytoma 4 | 2,287
Abnormally small eyeball 3 | 97
Aggressive behavior 3 | 75
Aggressive reaction 3 | 75
Atopic dermatitis 3 | 952
Broad flat nasal bridge 3 | 236
Decreased size of eyeball 3 | 97
Intrauterine retardation 3 | 176
Joint hyperflexibility 3 | 78
Low Birth Weights 3 | 69
Nasal bridge wide 3 | 236
Penile hypospadias 3 | 106
Physical aggression 3 | 76
Small for gestational age (disorder) 3 | 69
Specific learning disability 3 | 47
Speech Disorders 3 | 58
adult high grade glioma 3 | 3,801
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
dermatomyositis 3 | 966
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
invasive ductal carcinoma 3 | 2,951
pediatric high grade glioma 3 | 1,064
tuberculosis 3 | 2,010

Tissue

Blood and immune system 29 | 16,909
Digestive Tract 29 | 17,369
Endocrine System 29 | 18,159
Female tissues 29 | 17,400
Liver and Pancreas 29 | 16,750
Male tissues 29 | 17,142
Nervous System 29 | 16,725
Skin and soft tissues 29 | 17,230
Urinary Tract 29 | 16,678
Cardiovascular System 28 | 15,192
Respiratory system 28 | 16,393

Target Family

Non-IDG 14 | 12,091
Transcription Factor 9 | 1,400
Epigenetic 3 | 242
Enzyme 2 | 4,145
Nuclear Receptor 1 | 48

GO Function

RNA polymerase II repressing t... 29 | 29
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Bardet-Biedl syndrome 4 protein BBS4 Tbio Non-IDG -1.53435 31.5 200
Chromodomain-helicase-DNA-binding protein 4 CHD4 Tbio Epigenetic -2.22229 159.7 203
DNA endonuclease RBBP8 RBBP8 Tbio Enzyme -2.17933 148.4 308
Bardet-Biedl syndrome 2 protein BBS2 Tbio Non-IDG -2.84516 693.9 69
Metastasis-associated protein MTA2 MTA2 Tbio Transcription Factor -1.59201 32.3 283
Homeobox protein MIXL1 MIXL1 Tbio Transcription Factor -2.76027 560.5 117
Transcription factor GATA-6 GATA6 Tbio Transcription Factor -2.41909 265.8 367
Tetratricopeptide repeat protein 8 TTC8 Tbio Non-IDG -0.60005 3.72 177
Transcription elongation regulator 1 TCERG1 Tbio Non-IDG -2.31125 194.9 140
TATA-box-binding protein TBP Tbio Non-IDG -3.27246 1844.4 387