Development Level

Tbio 131 | 10,625
Tdark 48 | 7,003
Tchem 15 | 1,890
Tclin 6 | 602

IMPC Term

preweaning lethality, incomple... 7 | 260
preweaning lethality, complete... 6 | 633
abnormal bone structure 5 | 131
embryonic lethality prior to t... 4 | 187
increased mean corpuscular vol... 4 | 91
abnormal cornea morphology 3 | 24
abnormal embryo size 3 | 112
abnormal eye morphology 3 | 38
decreased body length 3 | 108
decreased body weight 3 | 174
decreased circulating triglyce... 3 | 83
enlarged heart 3 | 111
hyperactivity 3 | 108
abnormal behavior 2 | 226
abnormal bone mineralization 2 | 55
abnormal forebrain development 2 | 18
abnormal gait 2 | 51
abnormal heart morphology 2 | 51
abnormal hindbrain development 2 | 24
abnormal kidney morphology 2 | 30
abnormal neural tube closure 2 | 37
abnormal retina morphology 2 | 100
abnormal retinal pigmentation 2 | 61
decreased bone mineral content 2 | 157
decreased caudal vertebrae num... 2 | 49
decreased lean body mass 2 | 195
decreased thermal nociceptive ... 2 | 4
decreased total body fat amoun... 2 | 186
female infertility 2 | 34
increased bone mineral content 2 | 92
increased circulating creatini... 2 | 29
increased circulating sodium l... 2 | 71
increased or absent threshold ... 2 | 128
increased thermal nociceptive ... 2 | 9
male infertility 2 | 62
short tibia 2 | 82
abnormal coat/hair pigmentatio... 1 | 54
abnormal epididymis morphology 1 | 31
abnormal eyelid morphology 1 | 6
abnormal facial morphology 1 | 9
abnormal limb bud morphology 1 | 15
abnormal locomotor activation 1 | 26
abnormal midbrain development 1 | 22
abnormal optic disc morphology 1 | 10
abnormal placenta morphology 1 | 4
abnormal spinal cord morpholog... 1 | 8
abnormal spleen morphology 1 | 36
abnormal tail morphology 1 | 17
abnormal vitreous body morphol... 1 | 7
absent vibrissae 1 | 14
cleft palate 1 | 6
corneal opacity 1 | 25
corneal vascularization 1 | 5
cyanosis 1 | 6
decreased IgG1 level 1 | 4
decreased Ly6C low monocyte nu... 1 | 23
decreased T cell number 1 | 31
decreased anxiety-related resp... 1 | 12
decreased basophil cell number 1 | 11
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating creatini... 1 | 31
decreased circulating free fat... 1 | 39
decreased circulating magnesiu... 1 | 11
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased effector memory CD8-... 1 | 24
decreased grip strength 1 | 123
decreased hemoglobin content 1 | 53
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular hem... 1 | 19
decreased mean corpuscular vol... 1 | 50
decreased threshold for audito... 1 | 32
decreased vertical activity 1 | 22
embryonic lethality prior to o... 1 | 148
enlarged spleen 1 | 26
fused cornea and lens 1 | 4
hemorrhage 1 | 12
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
increased body length 1 | 20
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating alkaline... 1 | 119
increased circulating choleste... 1 | 53
increased circulating iron lev... 1 | 25
increased circulating triglyce... 1 | 24
increased effector memory CD4-... 1 | 15
increased grip strength 1 | 83
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 93
increased mean corpuscular hem... 1 | 25
increased plasma cell number 1 | 5
increased total body fat amoun... 1 | 57
narrow eye opening 1 | 15
oligodactyly 1 | 14
persistence of hyaloid vascula... 1 | 22
prenatal lethality prior to he... 1 | 64
thin ventricular wall 1 | 5
vertebral fusion 1 | 23

Disease

osteosarcoma 92 | 7,933
ovarian cancer 82 | 8,484
psoriasis 81 | 6,685
medulloblastoma, large-cell 76 | 6,234
glioblastoma 63 | 5,572
Cancer 55 | 2,346
lung cancer 54 | 4,466
atypical teratoid / rhabdoid tumor 51 | 4,369
Breast cancer 48 | 3,094
primitive neuroectodermal tumor 41 | 3,031
invasive ductal carcinoma 39 | 2,950
malignant mesothelioma 39 | 3,162
group 4 medulloblastoma 34 | 1,875
intraductal papillary-mucinous carcinoma (IPMC) 31 | 2,988
lung carcinoma 30 | 2,844
intraductal papillary-mucinous adenoma (IPMA) 29 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 29 | 3,289
pilocytic astrocytoma 29 | 3,086
ependymoma 26 | 2,514
non-small cell lung cancer 24 | 2,798
ulcerative colitis 24 | 2,087
group 3 medulloblastoma 23 | 2,254
interstitial cystitis 23 | 2,299
oligodendroglioma 23 | 2,849
pediatric high grade glioma 23 | 2,712
pituitary cancer 23 | 1,972
pancreatic cancer 22 | 2,300
lung adenocarcinoma 21 | 2,713
astrocytic glioma 20 | 2,241
ductal carcinoma in situ 20 | 1,745
Carcinoma 19 | 2,147
adult high grade glioma 19 | 2,148
breast carcinoma 19 | 1,614
diabetes mellitus 19 | 1,663
subependymal giant cell astrocytoma 19 | 2,287
Rheumatoid Arthritis 18 | 1,160
medulloblastoma 18 | 1,524
sonic hedgehog group medulloblastoma 18 | 1,482
colon cancer 16 | 1,475
Pick disease 15 | 1,893
cutaneous lupus erythematosus 15 | 1,056
cystic fibrosis 15 | 1,665
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,795
posterior fossa group A ependymoma 15 | 1,511
adrenocortical carcinoma 14 | 1,427
astrocytoma 14 | 1,493
tuberculosis 14 | 1,557
primary pancreatic ductal adenocarcinoma 13 | 1,271
acute myeloid leukemia 12 | 780
posterior fossa group B ependymoma 12 | 1,530
spina bifida 12 | 1,064
Cleft palate 11 | 125
Multiple myeloma 11 | 1,327
gastric carcinoma 11 | 832
primary Sjogren syndrome 11 | 789
Craniofacial Abnormalities 10 | 147
Prostatic Neoplasms 10 | 471
non primary Sjogren syndrome sicca 10 | 840
Atopic dermatitis 9 | 944
Obesity 9 | 616
Stomach Neoplasms 9 | 282
Waldenstrons macroglobulinemia 9 | 765
acute quadriplegic myopathy 9 | 1,157
atypical teratoid/rhabdoid tumor 9 | 1,095
esophageal adenocarcinoma 9 | 737
juvenile dermatomyositis 9 | 1,189
tuberculosis and treatment for 6 months 9 | 686
Congenital heart disease 8 | 63
Vascular disease 8 | 281
aldosterone-producing adenoma 8 | 664
dermatomyositis 8 | 933
Down syndrome 7 | 548
Heart disease 7 | 279
facioscapulohumeral dystrophy 7 | 286
Autistic Disorder 6 | 320
Bipolar Disorder 6 | 266
Cholestasis 6 | 93
Cleft Lip 6 | 91
Intellectual disability 6 | 573
Kaposi's Sarcoma Skin Lesions 6 | 7
Liver carcinoma 6 | 217
Polydactyly 6 | 93
Precursor Cell Lymphoblastic Leukemia Lymphoma 6 | 42
active Crohn's disease 6 | 918
active ulcerative colitis 6 | 477
fibroadenoma 6 | 557
mucosa-associated lymphoid tissue lymphoma 6 | 480
Acquired metabolic disease 5 | 267
Cardiovascular system disease 5 | 194
Crohn's disease 5 | 304
Diabetes Mellitus, Non-Insulin-Dependent 5 | 157
Kidney disease 5 | 396
Mammary Neoplasms 5 | 410
Schizophrenia 5 | 501
Tetralogy of Fallot 5 | 35
Tooth agenesis 5 | 36
chronic rhinosinusitis 5 | 512
glioblastoma multiforme 5 | 347
inflammatory breast cancer 5 | 404
nephrosclerosis 5 | 329

Tissue

Nervous System 199 | 18,561
Digestive Tract 198 | 18,473
Endocrine System 198 | 18,512
Female tissues 198 | 18,647
Urinary Tract 198 | 18,444
Cardiovascular System 197 | 17,958
Skin and soft tissues 197 | 18,115
Liver and Pancreas 196 | 18,136
Male tissues 195 | 17,969
Blood and immune system 192 | 17,995
Respiratory system 186 | 17,484

Target Family

Transcription Factor 164 | 1,400
Non-IDG 14 | 11,971
Nuclear Receptor 11 | 48
Epigenetic 6 | 242
TF/Epigenetic 3 | 38
Enzyme 1 | 4,146
Kinase 1 | 634

GO Function

RNA polymerase II regulatory r... 200 | 200
metal ion binding 1,917 | 1,917
ATP binding 1,467 | 1,467
DNA binding 1,432 | 1,432
zinc ion binding 1,155 | 1,155
poly(A) RNA binding 1,107 | 1,107
transcription factor activity,... 853 | 853
calcium ion binding 695 | 695
G-protein coupled receptor act... 661 | 661
protein homodimerization activ... 569 | 569
RNA binding 445 | 445
olfactory receptor activity 424 | 424
sequence-specific DNA binding 398 | 398
GTP binding 374 | 374
chromatin binding 372 | 372
protein serine/threonine kinas... 336 | 336
RNA polymerase II core promote... 332 | 332
identical protein binding 311 | 311
nucleotide binding 311 | 311
receptor binding 303 | 303
protein kinase binding 289 | 289
enzyme binding 286 | 286
cadherin binding involved in c... 277 | 277
GTPase activator activity 273 | 273
ubiquitin protein ligase bindi... 258 | 258
ubiquitin-protein transferase ... 253 | 253
serine-type endopeptidase acti... 246 | 246
transcription coactivator acti... 241 | 241
transcription factor binding 240 | 240
structural molecule activity 232 | 232
GTPase activity 231 | 231
transcriptional activator acti... 230 | 230
ligase activity 227 | 227
protein heterodimerization act... 227 | 227
structural constituent of ribo... 212 | 212
transcription regulatory regio... 202 | 202
transmembrane signaling recept... 201 | 201
receptor activity 200 | 200
transcription corepressor acti... 198 | 198
magnesium ion binding 197 | 197
signal transducer activity 196 | 196
nucleic acid binding 184 | 184
protein kinase activity 183 | 183
carbohydrate binding 180 | 180
ubiquitin protein ligase activ... 173 | 173
RNA polymerase II transcriptio... 162 | 162
heparin binding 160 | 160
iron ion binding 141 | 141
lipid binding 136 | 136
transporter activity 136 | 136
actin binding 133 | 133
ATPase activity 132 | 132
protein C-terminus binding 129 | 129
heme binding 127 | 127
microtubule binding 123 | 123
protein tyrosine kinase activi... 119 | 119
cytokine activity 118 | 118
Ras guanyl-nucleotide exchange... 113 | 113
mRNA binding 112 | 112
metalloendopeptidase activity 112 | 112
transcriptional repressor acti... 110 | 110
structural constituent of cyto... 108 | 108
Rab GTPase binding 105 | 105
antigen binding 104 | 104
protein domain specific bindin... 102 | 102
peptide antigen binding 101 | 101
guanyl-nucleotide exchange fac... 98 | 98
protein complex binding 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 92 | 92
oxidoreductase activity 91 | 91
transcriptional activator acti... 91 | 91
actin filament binding 89 | 89
hydrolase activity 89 | 89
ion channel binding 89 | 89
protein tyrosine phosphatase a... 88 | 88
electron carrier activity 87 | 87
protease binding 87 | 87
histone binding 86 | 86
integrin binding 83 | 83
growth factor activity 82 | 82
phospholipid binding 82 | 82
single-stranded DNA binding 81 | 81
unfolded protein binding 77 | 77
kinase activity 75 | 75
thiol-dependent ubiquitin-spec... 75 | 75
phosphatidylinositol binding 74 | 74
calmodulin binding 73 | 73
histone deacetylase binding 73 | 73
Rho guanyl-nucleotide exchange... 72 | 72
drug binding 71 | 71
double-stranded DNA binding 70 | 70
peptidase activity 70 | 70
protein N-terminus binding 70 | 70
virus receptor activity 68 | 68
beta-catenin binding 67 | 67
microtubule motor activity 67 | 67
protein transporter activity 67 | 67
calcium channel activity 66 | 66
ubiquitin binding 66 | 66

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Achaete-scute homolog 5 ASCL5 Tdark Non-IDG 0.11 0
Class A basic helix-loop-helix protein 15 BHLHA15 Tbio Transcription Factor -1.24086 19.1 70
POU domain, class 3, transcription factor 4 POU3F4 Tbio Transcription Factor -2.24459 179.3 55
Zinc finger protein GLIS1 GLIS1 Tbio Transcription Factor -0.87828 10.0 91
Zinc finger protein GLIS2 GLIS2 Tbio Transcription Factor -1.86726 74.7 85
BarH-like 1 homeobox protein BARHL1 Tbio Transcription Factor -1.06351 11.8 78
Homeobox protein Hox-D8 HOXD8 Tbio Transcription Factor -1.03632 9.95 167
Cyclic AMP-responsive element-binding protein 3 CREB3 Tbio Transcription Factor -1.61736 42.0 159
Erythroid transcription factor GATA1 Tbio Transcription Factor -2.97791 941.1 675
Zinc finger BED domain-containing protein 6 ZBED6 Tdark Non-IDG -0.79472 9.28 0