Development Level

Tbio 161 | 11,445
Tchem 19 | 1,598
Tdark 16 | 6,588
Tclin 8 | 613

IMPC Phenotype

preweaning lethality, complete... 12 | 979
preweaning lethality, incomple... 10 | 499
abnormal bone structure 6 | 187
decreased vertical activity 5 | 208
enlarged heart 5 | 210
abnormal embryo size 4 | 220
abnormal heart morphology 4 | 162
decreased total body fat amoun... 4 | 207
male infertility 4 | 123
abnormal cornea morphology 3 | 31
abnormal eye morphology 3 | 68
decreased body length 3 | 101
decreased body weight 3 | 161
decreased bone mineral content 3 | 151
decreased circulating glucose ... 3 | 126
decreased circulating triglyce... 3 | 79
decreased lean body mass 3 | 135
decreased mean corpuscular vol... 3 | 79
embryonic growth retardation 3 | 106
embryonic lethality prior to t... 3 | 278
female infertility 3 | 60
hyperactivity 3 | 148
impaired glucose tolerance 3 | 75
increased body length 3 | 32
increased mean corpuscular vol... 3 | 92
increased startle reflex 3 | 112
increased total body fat amoun... 3 | 134
short tibia 3 | 97
abnormal behavior 2 | 298
abnormal bone mineralization 2 | 38
abnormal epididymis morphology 2 | 42
abnormal gait 2 | 69
abnormal kidney morphology 2 | 65
abnormal ovary morphology 2 | 7
abnormal retina morphology 2 | 71
abnormal seminal vesicle morph... 2 | 114
abnormal spleen morphology 2 | 55
absent epididymis 2 | 3
absent seminal vesicle 2 | 4
decreased bone mineral density 2 | 126
decreased circulating amylase ... 2 | 28
decreased circulating serum al... 2 | 82
decreased lymphocyte cell numb... 2 | 83
decreased prepulse inhibition 2 | 82
enlarged spleen 2 | 41
increased bone mineral content 2 | 108
increased bone mineral density 2 | 72
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased circulating aspartat... 2 | 15
increased circulating choleste... 2 | 66
increased circulating creatini... 2 | 38
increased circulating sodium l... 2 | 71
increased circulating triglyce... 2 | 42
increased grip strength 2 | 41
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
increased mean corpuscular hem... 2 | 36
increased or absent threshold ... 2 | 101
small uterus 2 | 3
thin ventricular wall 2 | 24
abnormal coat appearance 1 | 31
abnormal coat-hair pigmentatio... 1 | 64
abnormal limb bud morphology 1 | 17
abnormal locomotor activation 1 | 16
abnormal locomotor behavior 1 | 24
abnormal neural tube closure 1 | 46
abnormal placenta morphology 1 | 5
abnormal retinal inner nuclear... 1 | 8
abnormal testis morphology 1 | 43
abnormal vitreous body morphol... 1 | 10
absent vibrissae 1 | 12
corneal opacity 1 | 32
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased anxiety-related resp... 1 | 12
decreased caudal vertebrae num... 1 | 53
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating creatini... 1 | 39
decreased circulating magnesiu... 1 | 13
decreased circulating sodium l... 1 | 22
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased mean corpuscular hem... 1 | 31
decreased red blood cell distr... 1 | 41
decreased total retina thickne... 1 | 17
embryonic lethality prior to o... 1 | 239
hemorrhage 1 | 23
hypoactivity 1 | 132
increased circulating alanine ... 1 | 13
increased lactate dehydrogenas... 1 | 3
increased leukocyte cell numbe... 1 | 47
increased monocyte cell number 1 | 63
long tibia 1 | 25
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
small superior vagus ganglion 1 | 74
small thymus 1 | 16
vertebral fusion 1 | 23

Disease

Carcinoma 133 | 11,493
psoriasis 98 | 6,694
osteosarcoma 96 | 7,950
ovarian cancer 94 | 8,520
medulloblastoma, large-cell 83 | 6,241
Cancer 72 | 2,499
glioblastoma 70 | 5,792
atypical teratoid / rhabdoid tumor 63 | 5,112
lung cancer 60 | 4,740
Breast cancer 59 | 3,578
group 3 medulloblastoma 49 | 4,104
ependymoma 48 | 4,679
invasive ductal carcinoma 45 | 2,951
malignant mesothelioma 45 | 3,232
adult high grade glioma 38 | 3,801
primitive neuroectodermal tumor 38 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 37 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 36 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 32 | 2,955
Astrocytoma, Pilocytic 31 | 3,081
non-small cell lung cancer 31 | 2,890
pancreatic cancer 31 | 2,398
oligodendroglioma 30 | 2,850
interstitial cystitis 29 | 2,312
lung carcinoma 29 | 2,843
diabetes mellitus 28 | 1,728
lung adenocarcinoma 28 | 2,716
pituitary cancer 28 | 1,972
group 4 medulloblastoma 27 | 1,855
subependymal giant cell astrocytoma 27 | 2,287
Kidney cancer 26 | 2,613
ulcerative colitis 25 | 1,819
ductal carcinoma in situ 24 | 1,745
Rheumatoid arthritis 23 | 1,191
astrocytic glioma 23 | 2,597
breast carcinoma 23 | 1,638
colon cancer 22 | 1,478
astrocytoma 20 | 1,146
pancreatic ductal adenocarcinoma liver metastasis 20 | 1,962
Schizophrenia 19 | 1,160
adrenocortical carcinoma 19 | 1,428
tuberculosis 18 | 2,010
Cleft Palate 17 | 271
Pick disease 17 | 1,894
cutaneous lupus erythematosus 17 | 1,057
Multiple myeloma 16 | 1,332
Prostatic Neoplasms 16 | 495
primary pancreatic ductal adenocarcinoma 16 | 1,109
Intellectual disability 15 | 1,016
acute quadriplegic myopathy 15 | 1,158
spina bifida 15 | 1,074
Waldenstrons macroglobulinemia 14 | 765
cystic fibrosis 14 | 1,696
juvenile dermatomyositis 14 | 1,187
acute myeloid leukemia 13 | 783
pediatric high grade glioma 13 | 1,064
Carcinoma, Hepatocellular 12 | 228
Obesity 12 | 678
Autosomal recessive predisposition 11 | 1,442
Breast Neoplasms 11 | 445
Cleft Lip 11 | 141
Craniofacial Abnormalities 11 | 151
Epilepsy 11 | 792
Liver carcinoma 11 | 240
Stomach Neoplasms 11 | 300
aldosterone-producing adenoma 11 | 665
gastric carcinoma 11 | 807
primary Sjogren syndrome 11 | 735
Atopic dermatitis 10 | 952
Bipolar Disorder 10 | 666
Dull intelligence 10 | 645
Low intelligence 10 | 645
Lung Neoplasms 10 | 232
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Polycystic ovary syndrome 10 | 360
Poor school performance 10 | 645
Precursor Cell Lymphoblastic Leukemia-Lymphoma 10 | 49
Seizures 10 | 596
Mammary Neoplasms 9 | 425
Parkinson's disease 9 | 392
Short stature 9 | 531
dermatomyositis 9 | 966
esophageal adenocarcinoma 9 | 737
medulloblastoma 9 | 720
Cholestasis 8 | 155
Cognitive delay 8 | 608
Congenital heart disease 8 | 93
Global developmental delay 8 | 608
Mental and motor retardation 8 | 608
Precursor Cell Lymphoblastic Leukemia Lymphoma 8 | 43
Tooth agenesis 8 | 44
Uranostaphyloschisis 8 | 167
Vascular disease 8 | 319
active ulcerative colitis 8 | 764
non primary Sjogren syndrome sicca 8 | 891
posterior fossa group A ependymoma 8 | 468
sonic hedgehog group medulloblastoma 8 | 467
Crohn's disease 7 | 321
Hypoplastic mandible condyle 7 | 275

Tissue

Endocrine System 199 | 18,159
Digestive Tract 190 | 17,369
Female tissues 189 | 17,400
Skin and soft tissues 186 | 17,230
Male tissues 185 | 17,142
Nervous System 175 | 16,725
Blood and immune system 172 | 16,909
Liver and Pancreas 172 | 16,750
Urinary Tract 170 | 16,678
Respiratory system 163 | 16,393
Cardiovascular System 147 | 15,192

Target Family

Transcription Factor 156 | 1,400
Non-IDG 19 | 12,091
Nuclear Receptor 14 | 48
Epigenetic 7 | 242
TF/Epigenetic 4 | 38
Enzyme 3 | 4,145
Kinase 1 | 634

GO Function

RNA polymerase II regulatory r... 204 | 204
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transcription factor CP2-like protein 1 TFCP2L1 Tbio Transcription Factor -1.10701 12.4 231
Pre-B-cell leukemia transcription factor 2 PBX2 Tbio Transcription Factor -1.90701 75.7 168
Y-box-binding protein 3 YBX3 Tbio Transcription Factor -2.13168 143.1 204
Homeobox protein MSX-1 MSX1 Tbio Transcription Factor -2.59245 390.1 298
Zinc finger transcription factor Trps1 TRPS1 Tbio Transcription Factor -1.98756 107.0 69
Achaete-scute homolog 4 ASCL4 Tdark Transcription Factor -0.31083 1.97 22
AT-rich interactive domain-containing protein 5B ARID5B Tbio Transcription Factor -1.71561 54.6 97
CCAAT/enhancer-binding protein beta CEBPB Tbio Transcription Factor -2.96589 857.9 436
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
Homeobox protein Hox-D9 HOXD9 Tbio Transcription Factor -1.52954 36.2 137