Development Level

Tbio 44 | 11,651
Tchem 7 | 1,388
Tclin 1 | 612

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal bone structure 2 | 187
decreased circulating creatini... 2 | 39
decreased circulating insulin ... 2 | 76
embryonic lethality prior to t... 2 | 278
increased circulating alkaline... 2 | 122
increased circulating choleste... 2 | 66
increased circulating triglyce... 2 | 42
increased startle reflex 2 | 112
abnormal bone mineralization 1 | 38
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal iris morphology 1 | 13
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal locomotor activation 1 | 16
abnormal ovary morphology 1 | 7
abnormal pupil morphology 1 | 2
abnormal response to new envir... 1 | 10
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal sleep behavior 1 | 70
abnormal tooth morphology 1 | 24
absent epididymis 1 | 3
absent ovary 1 | 3
absent vibrissae 1 | 12
cataract 1 | 92
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased monocyte cell number 1 | 8
decreased startle reflex 1 | 75
decreased thermal nociceptive ... 1 | 2
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
improved glucose tolerance 1 | 79
increased B cell number 1 | 9
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating free fat... 1 | 20
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
increased lactate dehydrogenas... 1 | 3
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased or absent threshold ... 1 | 101
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
polycystic kidney 1 | 15
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
prolonged PR interval 1 | 15
tremors 1 | 39

Disease

Carcinoma 34 | 11,493
osteosarcoma 28 | 7,950
ovarian cancer 26 | 8,520
psoriasis 26 | 6,694
Cancer 22 | 2,499
medulloblastoma, large-cell 21 | 6,241
atypical teratoid / rhabdoid tumor 19 | 5,112
lung cancer 19 | 4,740
glioblastoma 15 | 5,792
group 3 medulloblastoma 14 | 4,104
Breast cancer 13 | 3,578
diabetes mellitus 13 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
invasive ductal carcinoma 11 | 2,951
malignant mesothelioma 11 | 3,232
non-small cell lung cancer 11 | 2,890
primitive neuroectodermal tumor 11 | 3,035
ependymoma 10 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 10 | 2,955
tuberculosis 10 | 2,010
Intellectual disability 9 | 1,016
colon cancer 9 | 1,478
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
lung carcinoma 9 | 2,843
ulcerative colitis 9 | 1,819
Kidney cancer 8 | 2,613
breast carcinoma 8 | 1,638
group 4 medulloblastoma 8 | 1,855
interstitial cystitis 8 | 2,312
pancreatic cancer 8 | 2,398
Astrocytoma, Pilocytic 7 | 3,081
Epilepsy 7 | 792
Multiple myeloma 7 | 1,332
Waldenstrons macroglobulinemia 7 | 765
adult high grade glioma 7 | 3,801
cutaneous lupus erythematosus 7 | 1,057
lung adenocarcinoma 7 | 2,716
oligodendroglioma 7 | 2,850
pituitary cancer 7 | 1,972
Dull intelligence 6 | 645
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Poor school performance 6 | 645
Schizophrenia 6 | 1,160
acute myeloid leukemia 6 | 783
dermatomyositis 6 | 966
Autosomal recessive predisposition 5 | 1,442
Cognitive delay 5 | 608
Constipation 5 | 181
Crohn's disease 5 | 321
Cryptorchidism 5 | 296
Dyschezia 5 | 135
Global developmental delay 5 | 608
Mental and motor retardation 5 | 608
Muscle hypotonia 5 | 571
Osteoporosis 5 | 363
Parkinson's disease 5 | 392
adrenocortical carcinoma 5 | 1,428
astrocytoma 5 | 1,146
ductal carcinoma in situ 5 | 1,745
primary Sjogren syndrome 5 | 735
subependymal giant cell astrocytoma 5 | 2,287
Acquired metabolic disease 4 | 336
Breast Neoplasms 4 | 445
Down syndrome 4 | 499
Endometrial cancer 4 | 311
Endometriosis 4 | 540
Heat Stroke 4 | 13
Hyperglycemia 4 | 137
Leukemia, Myelocytic, Acute 4 | 120
Leukemia, Myeloid, Acute 4 | 105
Liver Cirrhosis, Experimental 4 | 769
Liver carcinoma 4 | 240
Liver neoplasms 4 | 130
Mammary Neoplasms 4 | 425
Obesity 4 | 678
Rheumatoid arthritis 4 | 1,191
Seizures 4 | 596
Short stature 4 | 531
Strabismus 4 | 270
astrocytic glioma 4 | 2,597
cystic fibrosis 4 | 1,696
nephrosclerosis 4 | 333
pancreatic carcinoma 4 | 562
Acquired scoliosis 3 | 281
Alzheimer's disease 3 | 658
Anteverted nostril 3 | 191
Attention deficit hyperactivity disorder 3 | 278
Broad flat nasal bridge 3 | 236
Chronic Lymphocytic Leukemia 3 | 262
Curvature of spine 3 | 282
Diabetes Mellitus, Non-Insulin-Dependent 3 | 145
Diabetes Mellitus, Type 2 3 | 142
Pick disease 3 | 1,894
Prostatic Neoplasms 3 | 495
acute quadriplegic myopathy 3 | 1,158
aldosterone-producing adenoma 3 | 665
hepatocellular carcinoma 3 | 547
pediatric high grade glioma 3 | 1,064

Tissue

Digestive Tract 51 | 17,369
Endocrine System 50 | 18,159
Skin and soft tissues 50 | 17,230
Blood and immune system 49 | 16,909
Female tissues 49 | 17,400
Male tissues 48 | 17,142
Liver and Pancreas 46 | 16,750
Respiratory system 45 | 16,393
Nervous System 44 | 16,725
Urinary Tract 44 | 16,678
Cardiovascular System 41 | 15,192

Target Family

Transcription Factor 39 | 1,400
Non-IDG 6 | 12,091
Nuclear Receptor 6 | 48
Enzyme 1 | 4,145

GO Function

RNA polymerase II distal enhan... 52 | 52
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nuclear factor erythroid 2-related factor 1 NFE2L1 Tbio Transcription Factor -1.57346 40.9 157
Bile acid receptor NR1H4 Tclin Nuclear Receptor -2.57379 350.3 293
Cyclic AMP-dependent transcription factor ATF-2 ATF2 Tbio Transcription Factor -2.23104 170.7 1819
Nuclear receptor subfamily 1 group D member 2 NR1D2 Tbio Nuclear Receptor -1.77473 57.5 205
Paired box protein Pax-4 PAX4 Tbio Transcription Factor -2.13674 146.6 229
Homeobox protein ARX ARX Tbio Transcription Factor -2.21255 163.7 328
Histone H3.3 H3F3B Tbio Non-IDG -2.14998 122.5 458
Homeobox protein Hox-B5 HOXB5 Tbio Transcription Factor -1.83782 66.4 179
Endothelial transcription factor GATA-2 GATA2 Tbio Transcription Factor -2.70355 475.5 354
Histone H2A.Z H2AFZ Tbio Non-IDG -2.53312 344.8 285