Development Level

Tbio 45 | 11,445
Tchem 12 | 1,598

IMPC Phenotype

preweaning lethality, complete... 6 | 979
decreased vertical activity 5 | 208
decreased circulating glucose ... 4 | 126
abnormal embryo size 3 | 220
embryonic lethality prior to t... 3 | 278
increased startle reflex 3 | 112
abnormal epididymis morphology 2 | 42
abnormal retina morphology 2 | 71
decreased circulating serum al... 2 | 82
embryonic growth retardation 2 | 106
increased neutrophil cell numb... 2 | 46
microphthalmia 2 | 26
prenatal lethality prior to he... 2 | 87
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal cecum morphology 1 | 7
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal forebrain morphology 1 | 10
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal ovary morphology 1 | 7
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal thymus morphology 1 | 7
absent epididymis 1 | 3
absent pinna reflex 1 | 23
anophthalmia 1 | 33
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating fructosa... 1 | 30
decreased circulating phosphat... 1 | 27
decreased circulating triglyce... 1 | 79
decreased heart left ventricle... 1 | 28
decreased hemoglobin content 1 | 68
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
embryonic lethality prior to o... 1 | 239
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
hemorrhage 1 | 23
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased body length 1 | 32
increased bone mineral density 1 | 72
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased heart rate 1 | 23
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased or absent threshold ... 1 | 101
increased prepulse inhibition 1 | 32
increased total body fat amoun... 1 | 134
increased total retina thickne... 1 | 4
mammalian phenotype 1 | 17
polycystic kidney 1 | 15
preweaning lethality, incomple... 1 | 499
shortened RR interval 1 | 17
small thymus 1 | 16

Disease

Carcinoma 40 | 11,493
osteosarcoma 35 | 7,950
Cancer 33 | 2,499
ovarian cancer 33 | 8,520
psoriasis 33 | 6,694
Breast cancer 27 | 3,578
lung cancer 24 | 4,740
medulloblastoma, large-cell 23 | 6,241
glioblastoma 22 | 5,792
group 3 medulloblastoma 21 | 4,104
malignant mesothelioma 19 | 3,232
invasive ductal carcinoma 18 | 2,951
atypical teratoid / rhabdoid tumor 17 | 5,112
pancreatic cancer 16 | 2,398
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
Intellectual disability 14 | 1,016
ependymoma 14 | 4,679
lung adenocarcinoma 14 | 2,716
non-small cell lung cancer 14 | 2,890
Rheumatoid arthritis 13 | 1,191
ductal carcinoma in situ 13 | 1,745
interstitial cystitis 13 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
adult high grade glioma 12 | 3,801
pituitary cancer 12 | 1,972
tuberculosis 12 | 2,010
Schizophrenia 11 | 1,160
Short stature 11 | 531
astrocytic glioma 11 | 2,597
breast carcinoma 11 | 1,638
cystic fibrosis 11 | 1,696
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
primitive neuroectodermal tumor 11 | 3,035
Dull intelligence 10 | 645
Low intelligence 10 | 645
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Poor school performance 10 | 645
diabetes mellitus 10 | 1,728
juvenile dermatomyositis 10 | 1,187
lung carcinoma 10 | 2,843
oligodendroglioma 10 | 2,850
Astrocytoma, Pilocytic 9 | 3,081
Cognitive delay 9 | 608
Epilepsy 9 | 792
Global developmental delay 9 | 608
Kidney cancer 9 | 2,613
Mental and motor retardation 9 | 608
Multiple myeloma 9 | 1,332
Seizures 9 | 596
Strabismus 9 | 270
adrenocortical carcinoma 9 | 1,428
group 4 medulloblastoma 9 | 1,855
Muscle hypotonia 8 | 571
Pick disease 8 | 1,894
acute myeloid leukemia 8 | 783
acute quadriplegic myopathy 8 | 1,158
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
subependymal giant cell astrocytoma 8 | 2,287
Craniofacial Abnormalities 7 | 151
Cryptorchidism 7 | 296
cutaneous lupus erythematosus 7 | 1,057
ulcerative colitis 7 | 1,819
Atopic dermatitis 6 | 952
Breast Neoplasms 6 | 445
Cleft Palate 6 | 271
Immune system cancer 6 | 140
Mammary Neoplasms 6 | 425
Obesity 6 | 678
Small head 6 | 374
Uranostaphyloschisis 6 | 167
Waldenstrons macroglobulinemia 6 | 765
pancreatic carcinoma 6 | 562
Alzheimer's disease 5 | 658
Amyotrophic lateral sclerosis 5 | 451
Autistic Disorder 5 | 364
Blepharoptosis 5 | 231
Cataract 5 | 297
Concave bridge of nose 5 | 195
Depressed nasal bridge 5 | 195
Depressed nasal root/bridge 5 | 195
Hypoplastic mandible condyle 5 | 275
Immunologic Deficiency Syndromes 5 | 113
Kidney disease 5 | 430
Lens Opacities 5 | 231
Liver carcinoma 5 | 240
Low set ears 5 | 181
Major Depressive Disorder 5 | 301
Mandibular hypoplasia 5 | 275
Melanoma 5 | 711
Micrognathism 5 | 275
Orbital separation excessive 5 | 244
Parkinson's disease 5 | 392
chronic lymphosyte leukemia 5 | 204
colon cancer 5 | 1,478
dermatomyositis 5 | 966
hepatocellular carcinoma 5 | 547
nasopharyngeal carcinoma 5 | 1,058
posterior fossa group A ependymoma 5 | 468
primary Sjogren syndrome 5 | 735

Tissue

Endocrine System 56 | 18,159
Female tissues 55 | 17,400
Nervous System 55 | 16,725
Blood and immune system 53 | 16,909
Digestive Tract 53 | 17,369
Male tissues 53 | 17,142
Respiratory system 53 | 16,393
Skin and soft tissues 53 | 17,230
Urinary Tract 52 | 16,678
Cardiovascular System 51 | 15,192
Liver and Pancreas 51 | 16,750

Target Family

Transcription Factor 37 | 1,400
Non-IDG 11 | 12,091
Epigenetic 5 | 242
Kinase 2 | 634
Nuclear Receptor 2 | 48

GO Function

RNA polymerase II core promote... 57 | 57
metal ion binding 2,256 | 2,256
DNA binding 1,481 | 1,481
ATP binding 1,477 | 1,477
RNA binding 1,383 | 1,383
identical protein binding 1,084 | 1,084
zinc ion binding 828 | 828
transcription factor activity,... 816 | 816
protein homodimerization activ... 801 | 801
calcium ion binding 690 | 690
G-protein coupled receptor act... 658 | 658
protein heterodimerization act... 473 | 473
olfactory receptor activity 425 | 425
protein kinase binding 410 | 410
chromatin binding 378 | 378
receptor binding 374 | 374
sequence-specific DNA binding 374 | 374
GTP binding 372 | 372
protein serine-threonine kinas... 360 | 360
RNA polymerase II core promote... 346 | 346
enzyme binding 340 | 340
ubiquitin protein ligase bindi... 301 | 301
transcription factor binding 297 | 297
GTPase activity 286 | 286
GTPase activator activity 281 | 281
cadherin binding 277 | 277
transcriptional activator acti... 274 | 274
actin binding 272 | 272
ubiquitin-protein transferase ... 260 | 260
transcription coactivator acti... 249 | 249
serine-type endopeptidase acti... 246 | 246
protein domain specific bindin... 241 | 241
protein complex binding 231 | 231
structural molecule activity 229 | 229
microtubule binding 212 | 212
nucleic acid binding 210 | 210
signal transducer activity 208 | 208
transcription regulatory regio... 205 | 205
RNA polymerase II regulatory r... 204 | 204
receptor activity 202 | 202
transmembrane signaling recept... 202 | 202
ubiquitin protein ligase activ... 202 | 202
transcription corepressor acti... 200 | 200
magnesium ion binding 197 | 197
calmodulin binding 194 | 194
protein C-terminus binding 191 | 191
protein kinase activity 182 | 182
carbohydrate binding 178 | 178
RNA polymerase II transcriptio... 174 | 174
cytokine activity 171 | 171
antigen binding 169 | 169
growth factor activity 162 | 162
heparin binding 161 | 161
protein dimerization activity 161 | 161
structural constituent of ribo... 161 | 161
actin filament binding 151 | 151
iron ion binding 139 | 139
transcriptional activator acti... 139 | 139
Rab GTPase binding 138 | 138
transcriptional repressor acti... 135 | 135
transporter activity 134 | 134
heme binding 129 | 129
ATPase activity 128 | 128
lipid binding 127 | 127
SH3 domain binding 125 | 125
protein tyrosine kinase activi... 122 | 122
ion channel binding 118 | 118
mRNA binding 118 | 118
Ras guanyl-nucleotide exchange... 116 | 116
metalloendopeptidase activity 115 | 115
unfolded protein binding 113 | 113
integrin binding 112 | 112
histone binding 111 | 111
protease binding 108 | 108
histone deacetylase binding 107 | 107
structural constituent of cyto... 107 | 107
guanyl-nucleotide exchange fac... 106 | 106
protein N-terminus binding 106 | 106
peptide antigen binding 103 | 103
hormone activity 96 | 96
serine-type endopeptidase inhi... 96 | 96
odorant binding 94 | 94
kinase binding 92 | 92
single-stranded DNA binding 92 | 92
chaperone binding 91 | 91
oxidoreductase activity 91 | 91
protein tyrosine phosphatase a... 91 | 91
PDZ domain binding 87 | 87
thiol-dependent ubiquitinyl hy... 86 | 86
kinase activity 84 | 84
transcriptional repressor acti... 84 | 84
beta-catenin binding 83 | 83
hydrolase activity 80 | 80
peptidase activity 80 | 80
protein binding, bridging 80 | 80
ATPase binding 79 | 79
double-stranded DNA binding 79 | 79
phospholipid binding 78 | 78
phosphatidylinositol binding 77 | 77
thiol-dependent ubiquitin-spec... 76 | 76
drug binding 75 | 75

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Catenin beta-1 CTNNB1 Tchem Non-IDG -3.99948 9786.0 3058
Signal transducer and activator of transcription 1-alpha/beta STAT1 Tchem Transcription Factor -3.33049 2009.0 1596
Heat shock factor protein 1 HSF1 Tbio Transcription Factor -2.27852 217.0 1246
Proto-oncogene c-Fos FOS Tbio Transcription Factor -4.14231 13598.8 1058
Signal transducer and activator of transcription 6 STAT6 Tchem Transcription Factor -2.91382 803.7 1033
Mothers against decapentaplegic homolog 1 SMAD1 Tbio Transcription Factor -0.93576 6.90 897
Histone acetyltransferase p300 EP300 Tchem Epigenetic -3.79743 6016.7 775
Erythroid transcription factor GATA1 Tbio Transcription Factor -3.00341 967.9 708
Hepatocyte nuclear factor 4-alpha HNF4A Tchem Nuclear Receptor -3.19918 1373.3 664
Trans-acting T-cell-specific transcription factor GATA-3 GATA3 Tbio Transcription Factor -3.20678 1568.2 636